An approach to the development of a short-term whole animal bioassay to distinguish initiating (incomplete) carcinogens complete carcinogens and noncarcinogens in the rat liver
Characterization of histochemically detectable altered hepatocyte foci and their relationship to hepatic tumorigenesis in rats treated once with diethylnitrosamine or benzo(a)pyrene within one day of birth
A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci
The quantitative analysis and stability of histochemical markers of altered hepatic foci in rat liver following initiation by diethylnitrosamine administration and promotion by phenobarbital
Induction and promotion of γ-glutamyltranspeptidase-positive foci in the livers of female rats treated with ethinyl estradiol, clomiphene, tamoxifen and their associations
Effects of ethinyl estradiol and tamoxifen on liver DNA turnover and new synthesis and appearance of gamma glutamyl transpeptidase positive foci in female rats
Hully J, Neveu M, Paul D, Campbell HA, Pitot HC. Deficiencies of connexin 32, a hepatospecific gap junction protein, and a cytoplasmic 28 kilodalton protein structurally related to c-fos as general markers for altered hepatic foci in hepatocarcinogenesis. Submitted.
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0022648148
The phenotypic stability of altered hepatic foci: Effect of the short-term withdrawal of phenobarbital and of the long-term feeding of the peripheral diets after the withdrawal of phenobarbital
Regulation and expression of four cytochrome P-450 isozymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver
Activities of benzphetamine-N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from γ-glutamyltranspeptidase-positive foci and surrounding liver
Effect of chronic phenobarbital administration on the gammaglutamyl transpeptidase activity of hyperplastic liver lesions induced in rats by the Solt/Farber initiation: Selection process of hepatocarcinogenesis
γ-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration