Characterization of the selectivity and mechanism of cytochrome P450 inhibition by dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylenedioxybiphenyl -2,2′-dicarboxylate

Drug Metabolism and Disposition

Volumn 29, Issue 12, 2001, Pages 1555-1560

  Kim, J Y ^a   Baek, M ^a   Lee, S ^a   Kim, S O ^a   Dong, M S ^a   Kim, B R ^a   Kim, D H ^a  

^a Korea Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIMETHOXY 5,6:5',6' BIS(METHYLENEDIOXY)BIPHENYL 2,2' DICARBOXYLIC ACID DIMETHYL ESTER; CAFFEINE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; DICARBOXYLIC ACID DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEMETHYLATION; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECTROSCOPY;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DIALYSIS; DIOXOLES; ENZYME INHIBITORS; HUMANS; MICROSOMES, LIVER; RATS; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0035193605     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Macrolide antibiotics as inducers and inhibitors of cytochrome P-450 in experimental animals and man
2. Metabolism of DDB by human liver microsomal cytochrome P450: Probable involvement of CYP3A and CYPIA2
3. Particular ability of cytochrome P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs
4. Metabolite-P450 complex formation by methylenedioxyphenyl HIV protease inhibitors in rat and human liver microsomes
5. Potent and selective inactivation of human liver microsomal cytochrome P450 isoform by L-754-394. An investigational human immune deficiency virus protease inhibitor
6. 1 activity
7. Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds
8. Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
9. Interactions of methylenedioxy phenol (1,3-benzodioxole) compounds with enzymes and their effects on mammals
10. Effect of dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate (DDB) on chemical induced liver injury
11. Enhanced effectiveness of dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate in combination with garlic oil against experimental hepatic injury in rats and mice
12. Prospective randomized controlled trial with biphenyl dimethyl dicarboxylate in chronic active liver diseases: The effects on lowering serum alanine aminotransferase levels
13. 3-demethylation by naturally occurring flavonoids
14. Modulation of cytochrome P450 activities by 7,8-benzoflavone and metabolites
15. TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver
16. Pharmacological properties of dibenzo [a, c]cyclooctene derivatives isolated from Fructus schizandrae chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids
17. Preparation of a porphyrin-iron-carbene model for the cytochrome P450 complexes obtained upon metabolic oxidation of the insecticide synergists of the 1,3-benzodioxole series
18. Spectral and inhibitory interactions of methyl-enedioxyphenyl and related compounds with purified isozymes of cytochrome P-450
19. Selective inhibitory interactions of alkylmethylenedioxybenxenes towards monooxygenase activity in rat hepatic microsomes
20. Selectivity in the inhibition of mammalian cytochrome P450 by chemical agents
21. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
22. Hydroxylation of chlorzoxazone as a specific probe for human lover cytochrome P450 2EI
23. The production and modification of cytochrome P450 difference spectra by in vivo administration of methylenedioxyphenyl compounds
24. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450 in the CYP2C subfamily
25. Metabolite intermediate complexation of microsomal cytochrome P450 2C11 in male rat by nortriptyline
26. Biphenyl-dimethyl dicarboxylate in treating and preventing hepatitis due to drug poisoning
27. Purification and characterization of human liver microsomal cytochrome P-450 2A6