Anti-HSP60 immunity is already associated with atherosclerosis early in life

Annals of the New York Academy of Sciences

Volumn 1051, Issue , 2005, Pages 323-331

  Knoflach, M ^a,b   Bernhard, D ^a   Wick, Georg ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b University Hospital for Neurology   (Austria)

Author keywords

Aging; Atherogenesis; Autoimmunity; Cardiovascular disease; Early atherosclerosis; Heat shock protein 60; Infection; Smoking; T cells

Indexed keywords

HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 60 ANTIBODY; HUMORAL ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

AGE; AGING; ANTIBODY TITER; ARTERY INTIMA PROLIFERATION; ATHEROGENESIS; ATHEROSCLEROSIS; AUTOIMMUNITY; B LYMPHOCYTE; CARDIOVASCULAR DISEASE; CELL INFILTRATION; CELLULAR IMMUNITY; CONFERENCE PAPER; CORRELATION ANALYSIS; ECHOGRAPHY; ENDOTHELIUM CELL; HUMAN; HUMORAL IMMUNITY; INTIMA; LYMPHOID TISSUE; MONONUCLEAR CELL; PROTEIN EXPRESSION; RISK ASSESSMENT; RISK FACTOR; SMOKING; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

EID: 25444446818     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1361.074     Document Type: Conference Paper

References (46)

1. BURKE, A.P., A. FARB, R. VIRMANI, et al. 1991. Sports-related and non-sports-related sudden cardiac death in young adults. Am. Heart J. 121(2 Pt 1): 568-575.
2. WISSLER, R.W. & J.P. STRONG. 1998. Risk factors and progression of atherosclerosis in youth. PDAY Research Group. Pathological Determinants of Atherosclerosis in Youth. Am. J. Pathol. 153: 1023-1033.
3. BERENSON, G.S., S.R. SRINIVASAN, W. BAO, et al. 1998. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N. Engl. J. Med. 338: 1650-1656.
4. KNOFLACH, M., S. KIECHL, M. KIND, et al. 2003. Cardiovascular risk factors and atherosclerosis in young males: ARMY study (Atherosclerosis Risk-Factors in Male Youngsters). Circulation 108: 1064-1069.
5. VIRCHOW, R. 1858. Die Cellularpathologie in ihrer Begründung auf Physiologische und Pathologische Gewebelehre. Zwanzig Vorlesungen. Berlin.
6. OSLER, W. 1908. Diseases of the arteries. In Modern Medicine. Its Theory and Practice in Original Contributions by Americans and Foreign Authors. Vol. 4. W. Osler & T. MacCrae, Eds. Lea & Febiger. Philadelphia.
7. FABRICANT, C.G., J. FABRICANT, M.M. LITRENTA & C.R. MINICK. 1978. Virus-induced atherosclerosis. J. Exp. Med. 148: 335-340.
8. ROSS, R. 1999. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340: 115-126.
9. HANSSON, G.K. 2001. Immune mechanisms in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 21: 1876-1890.
10. LIBBY, P. 2002. Inflammation in atherosclerosis. Nature 420: 868-874.
11. KIECHL, S., G. EGGER, M. MAYR, et al. 2001. Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study. Circulation 103: 1064-1070.
12. MILLONIG, G., C. SCHWENTNER, P. MUELLER, et al. 2001. The vascular-associated lymphoid tissue: a new site of local immunity. Curr. Opin. Lipidol. 12: 547-553.
13. MILLONIG, G., G.T. MALCOM & G. WICK. 2002. Early inflammatory- immunological lesions in juvenile atherosclerosis from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY)-study. Atherosclerosis 160: 441-448.
14. PAULSSON, G., X. ZHOU, E. TORNQUIST & G.K. HANSSON. 2000. Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 20: 10-17.
15. STEMME, S., L. RYMO & G.K. HANSSON. 1991. Polyclonal origin of T lymphocytes in human atherosclerotic plaques. Lab. Invest. 65: 654-660.
16. YOUNG, D.B. 1992. Heat-shock proteins: immunity and autoimmunity. Curr. Opin. Immunol. 4: 396-400.
17. BENJAMIN, I.J. & D.R. MCMILLAN. 1998. Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circ. Res. 83: 117-132.
18. XU, Q., H. DIETRICH, H.J. STEINER, et al. 1992. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler. Thromb. 12: 789-799.
19. METZLER, B., M. MAYR, H. DIETRICH, et al. 1999. Inhibition of arteriosclerosis by T-cell depletion in normocholesterolemic rabbits immunized with heat shock protein 65. Arterioscler. Thromb. Vasc. Biol. 19: 1905-1911.
20. AFEK, A., J. GEORGE, B. GILBURD, et al. 2000. Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis. J. Autoimmun. 14: 115-121.
21. HARATS, D., N. YACOV, B. GILBURD, et al. 2002. Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions. J. Am. Coll. Cardiol. 40: 1333-1338.
22. MARON, R., G. SUKHOVA, A.M. FARIA, et al. 2002. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 106: 1708-1715.
23. GEORGE, J., A. AFEK, B. GILBURD, et al. 2001. Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice. J. Am. Coll. Cardiol. 38: 900-905.
24. SCHETT, G., Q. XU, A. AMBERGER, et al. 1995. Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J. Clin. Invest. 96: 2569-2577.
25. SOLTYS, B.J. & R.S. GUPTA. 1997. Cell surface localization of the 60 kDa heat shock chaperonin protein (hsp60) in mammalian cells. Cell Biol. Int. 21: 315-320.
26. MAYR, M., B. METZLER, S. KIECHL, et al. 1999. Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of Escherichia coli and Chlamydia pneumoniae: immune reactions to heat shock proteins as a possible link between infection and atherosclerosis. Circulation 99: 1560-1566.
27. WICK, G., R. KLEINDIENST, H. DIETRICH, et al. 1992. Is atherosclerosis an autoimmune disease? Trends Food Sci. Technol. 3: 114-119.
28. WICK, G., H. PERSCHINKA & G. MILLONIG. 2001. Atherosclerosis as an autoimmune disease: an update. Trends Immunol. 22: 665-669.
29. WICK, G., M. KNOFLACH & Q. XU. 2004. Autoimmune and inflammatory mechanisms in atherosclerosis. Annu. Rev. Immunol. 22: 362-403.
30. AMBERGER, A., C. MACZEK, G. JURGENS, et al. 1997. Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial and venous endothelial cells in response to cytokines and oxidized low-density lipoproteins. Cell Stress & Chaperones 2: 94-103.
31. KIECHL, S. & J. WILLEIT. 1999. The natural course of atherosclerosis. Part I: incidence and progression. Arterioscler. Thromb. Vasc. Biol. 19: 1484-1490.
32. KIECHL, S. & J. WILLEIT. 1999. The natural course of atherosclerosis. Part II: vascular remodeling. Bruneck Study Group. Arterioscler. Thromb. Vasc. Biol. 19: 1491-1498.
33. XU, Q., J. WILLEIT, M. MAROSI, et al. 1993. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet 341: 255-259.
34. XU, Q., S. KIECHL, M. MAYR, et al. 1999. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis: clinical significance determined in a follow-up study. Circulation 100: 1169-1174.
35. XU, Q., G. SCHETT, H. PERSCHINKA, et al. 2000. Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population. Circulation 102: 14-20.
36. MILLONIG, G., H. NIEDEREGGER, W. RABL, et al. 2001. Network of vascular-associated dendritic cells in intima of healthy young individuals. Arterioscler. Thromb. Vasc. Biol. 21: 503-508.
37. PIGNOLI, P., E. TREMOLI, A. POLI, et al. 1986. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 74: 1399-1406.
38. XU, Q., R. KLEINDIENST, W. WAITZ, et al. 1993. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65. J. Clin. Invest. 91: 2693-2702.
39. KROEMER, G., N. NEU, T. KUEHR, et al. 1989. Immunogenetic analysis of spontaneous autoimmune thyroiditis of obese strain chickens. Clin. Immunol. Immunopathol. 52: 202-213.
40. HOCHLEITNER, B.W., E.O. HOCHLEITNER, P. OBRIST, et al. 2000. Fluid shear stress induces heat shock protein 60 expression in endothelial cells in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol. 20: 617-623.
41. SEITZ, C.S., R. KLEINDIENST, Q. XU & G. WICK. 1996. Coexpression of heat-shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin. Lab. Invest. 74: 241-252.
42. AMBERGER, A., M. HALA, M. SAURWEIN-TEISSL, et al. 1999. Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins. Mol. Med. 5: 117-128.
43. BERNHARD, D., G. PFISTER, C.W. HUCK, et al. 2003. Disruption of vascular endothelial homeostasis by tobacco smoke: impact on atherosclerosis. FASEB J. 17: 2302-2304.
44. BERNHARD, D., C.W. HUCK, T. JAKSCHITZ, et al. 2004. Development and evaluation of an in vitro model for the analysis of cigarette smoke effects on cultured cells and tissues. J. Pharmacol. Toxicol. Methods 50: 45-51.
45. BERNHARD, D., A. CSORDAS, B. HENDERSON, et al. 2005. Cigarette smoke metal catalyzed protein oxidation leads to vascular endothelial cell contraction by depolymerization of microtubules. FASEB J. In press.
46. PENN, A., K. KELLER, C. SNYDER, et al. 1996. The tar fraction of cigarette smoke does not promote arteriosclerotic plaque development. Environ. Health Perspect. 104: 1108-1113.