Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population

Circulation

Volumn 102, Issue 1, 2000, Pages 14-20

  Xu, Qingbo ^a   Schett, Georg ^b   Perschinka, Hannes ^c   Mayr, Manuel ^a   Egger, Georg ^d   Oberhollenzer, Friedrich ^d   Willeit, Johann ^c   Kiechl, Stefan ^c   Wick, Georg ^a,c  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d NONE

Author keywords

Aging; Atherosclerosis; Chaperonin 60; Heat shock proteins; Infection; Inflammation

Indexed keywords

HEAT SHOCK PROTEIN 60;

ADULT; AGED; AGING; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BACTERIAL INFECTION; CHLAMYDIA; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR;

EID: 0034604242     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.1.14     Document Type: Article

References (42)

1. Morimoto RI. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev. 1998;12:3788-2396.
2. Xu Q, Wick G. The role of heat shock proteins in protection and pathophysiology of the arterial wall. Mol Med Today. 1996;2:372-379.
3. Roma P, Catapano AL. Stress proteins and atherosclerosis. Atherosclerosis. 1996;127:147-154.
4. Benjamin IJ, McMillan DR. Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circ Res. 1998;83: 117-132.
5. Kol A, Sukhova GK, Lichtman AH, et al. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-α and matrix metalloproteinase expression. Circulation. 1998;98: 300-307.
6. Chen W, Syldath U, Bellmann K, et al. Human 60-kDa heat-shock protein: a danger signal to the innate immune system. J Immunol. 1999; 162:3212-3219.
7. Kol A, Bourcier T, Lichtman AH, et al. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. J Clin Invest. 1999;103:571-577.
8. Xu Q, Dietrich H, Steiner HJ, et al. Induction of atherosclerosis in normocholesterolemic rabbits by immunisation with heat shock protein 65. Arterioscler Thromb. 1992;12:789-799.
9. Xu Q, Willeit J, Marosi M, et al. Association of serum antibodies to heat shock-protein 65 with carotid atherosclerosis. Lancet. 1993;341:255-259.
10. Wick G, Romen M, Amberger A, et al. Atherosclerosis, autoimmunity and vascular-associated lymphoid tissue. FASEB J. 1997;11:1199-1207.
11. Willeit J, Kiechl S. Prevalence and risk factors of asymptomatic carotid artery atherosclerosis: a population-based study. Arterioscler Thromb. 1993;13:1666-1668.
12. Kiechl S, Willeit J, Egger G, et al. Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study. Circulation. 1997;96:3300-3307.
13. Kiechl S, Willeit J. The natural course of atherosclerosis, part I: incidence and progression. Arterioscler Thromb Vasc Biol. 1999;19:1484-1490.
14. Kiechl S, Willeit J. The natural course of atherosclerosis, part II: vascular remodeling. Arterioscler Thromb Vasc Biol. 1999;19:1491-1498.
15. Xu Q, Kiechl S, Mayr M, et al. Association of serum antibodies to heat shock-protein 65 with carotid atherosclerosis: clinical significance determined in a follow-up study. Circulation. 1999;100:1169-1174.
16. Singh B, Gupta RS. Expression of human 60-kD heat shock protein (HSP 60 or P1) in Escherichia coli and the development and characterization corresponding monoclonal antibodies. DNA Cell Biol. 1992;11:489-496.
17. Evans DJ, Norton P, Ivanyi J. Distribution in tissue sections of the human GroEL stress protein homologue. APMIS. 1990;98:437-441.
18. Mayr M, Metzler B, Kiechl S, et al. Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of E. coli and Chlamydia pneumoniae: immune reactions to heat shock proteins as a possible link between infections and atherosclerosis. Circulation. 1999;99:1560-1566.
19. Takahashi K, Fukada M, Kawai M, et al. Detection of lipopolysaccharide (LPS) and identification of its serotype by an enzyme-linked immunosorbent assay (ELISA) using poly-L-lysine. J Immunol Methods. 1992; 153:67-71.
20. Wiedermann CJ, Kiechl S, Dunzendorfer S, et al. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study. J Am Coll Cardiol 1999;34: 1975-1981.
21. Siedel J, Hagele EO, Ziegenhorn J, et al. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem. 1983;29:1075-1080.
22. Kronenberg F, Kronenberg MF, Kiechl S, et al. Role of lipoprotein(a) and apolipoprotein(a) phenotype in atherogenesis: prospective results from the Bruneck study. Circulation. 1999;100:1154-1160.
23. Clauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 1957;17:237-246.
24. Bonora E, Kiechl S, Willeit J, et al. Plasma glucose within the normal range is not associated with carotid atherosclerosis: prospective results in subjects with normal glucose tolerance from the Bruneck Study. Diabetes Care. 1999;22:1339-1346.
25. Hosmer DW, Lemeshow S. Applied Logistic Regression. New York: Wiley & Sons; 1988.
26. Saikku P, Leinonen M, Mattila K, et al. Serological evidence of an association of a novel chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet. 1988;2:983-986.
27. Thom DH, Wang SP, Grayston T, et al. Chlamydia pneumoniae strain TWAR antibody and angiographically demonstrated coronary artery disease. Arterioscler Thromb. 1991;11:547-551.
28. Hajjar DP, Fabricant CG, Minick CR, et al. Virus-induced atherosclerosis. Am J Pathol. 1986;122:62-70.
29. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999; 340:115-126.
30. Xu Q, Kleindienst R, Waitz W, et al. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65. J Clin Invest. 1993;91:2693-2702.
31. Gruber R, Lederer S, Bechtel U, et al. Increased antibody titers against myobacterial heat-shock protein 65 in patients with vasculitis and arteriosclerosis. Int Arch Allergy Immunol. 1996;110:95-98.
32. Mikherjee M, De Benedictis C, Jewitt D, et al. Association of antibodies to heat-shock protein-65 with percutaneous transluminal coronary angioplasty and subsequent restenosis. Thromb Haemost. 1996; 75:258-260.
33. Hoppichler F, Lechleitner M, Tragweger C, et al. Changes of serum antibodies to heat-shock protein 65 in coronary heart disease and acute myocardial infarction. Atherosclerosis. 1996;126:333-338.
34. Birnie DH, Holme ER, McKay IC, et al. Association between antibodies to heat shock protein 65 and coronary atherosclerosis: possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk. Eur Heart J. 1998;19: 387-394.
35. Xu Q, Schett G, Seitz CS, et al. Surface staining and cytotoxic activity of heat shock protein 60 antibody on stressed aortic endothelial cells. Circ Res. 1994;75:1078-1085.
36. Soltys BJ, Gupta RS. Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells. Exp Cell Res. 1996;222:16-27.
37. Yamaguchi H, Osaki T, Taguchi H, et al. Flow cytometric analysis of the heat shock protein 60 expressed on the cell surface of Helicobacter pylori. J Med Microbiol. 1996;45:270-277.
38. Beatty WL, Morrison RP, Byrne GI. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol Rev. 1994;58:686-699.
39. Young RA, Elliott TJ. Stress proteins, infection, and immune surveillance. Cell. 1989;59:5-8.
40. Kleindienst R, Xu Q, Willeit J, et al. Immunology of atherosclerosis: demonstration of heat shock protein 60 expression and T-lymphocytes bearing α/β or γ/δ receptor in human atherosclerotic lesions. Am J Pathol. 1993;142:1927-1937.
41. Kockx MM. Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects. Arterioscler Thromb Vasc Biol. 1998;18:1519-1522.
42. Haunstetter A, Izumo S. Apoptosis: basic mechanisms and implications for cardiovascular disease. Circ Res. 1998;82:1111-1129.