Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of Escherichia coli and Chlamydia pneumoniae: Immune reactions to heat shock proteins as a possible link between infection and atherosclerosis

Circulation

Volumn 99, Issue 12, 1999, Pages 1560-1566

  Mayr, Manuel ^a,c   Metzler, Bernhard ^a   Kiechl, Stefan ^b   Willeit, Johann ^b   Schett, Georg ^a   Xu, Qingbo ^a   Wick, Georg ^a,c  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Antibodies; Atherosclerosis; C pneumoniae; Immunology; Stress

Indexed keywords

ANTIBODY; HEAT SHOCK PROTEIN;

ADULT; AGED; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHLAMYDIASIS; CHLAMYDOPHILA PNEUMONIAE; CLINICAL ARTICLE; CROSS REACTION; CYTOTOXICITY; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE INFECTION; HUMAN; MALE; MOLECULAR MIMICRY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; VASCULAR ENDOTHELIUM;

EID: 0033616886     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.12.1560     Document Type: Article

References (32)

1. Libby P, Hansson GK. Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions. Lab Invest. 1991;64:5-15.
2. Wick G, Schett G, Amberger A, Kleindienst R, Xu Q. Is atherosclerosis an immunologically mediated disease? Immunol Today. 1995;16:27-33.
3. Vlaicu R, Niculescu F, Rus HG, Cristea A. Immunohistochemical localization of the terminal C5b-9 complement complex in human aortic fibrous plaque. Atherosclerosis. 1985;57:163-177.
4. Valtonen VV. Infection as a risk factor for infarction and atherosclerosis. Ann Med. 1991;23:539-543.
5. Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link? Lancet. 1997;350:430-436.
6. Stary HC. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis. 1989;9: 119-132.
7. Young RA, Elliott TJ. Stress proteins, infection, and immune surveillance. Cell. 1989;59:5-8.
8. Di Cesare S, Poccia F, Mastino A, Colizzi V. Surface expressed heat-shock proteins by stressed or human immunodeficiency virus (HIV)-infected lymphoid cells represent the target for antibody-dependent cellular cytotoxicity. Immunology. 1992;76:341-343.
9. Xu Q, Dietrich H, Steiner HJ, Gown AM, Schoel B, Mikuz G, Kaufman SHE, Wick G. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler Thromb. 1992;12:789-799.
10. Xu Q, Kleindienst R, Waitz, W, Dietrich H, Wick G. Increased expression of heat shock protein 65 coincides with a population of infiltrating T-lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65. J Clin Invest. 1993;91:2693-2702.
11. Xu Q, Willeit J, Marosi M, Kleindienst R, Oberhollenzer F, Kiechl S, Stulnig T, Luef G, Wick G. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet. 1993;341:255-259.
12. Willeit J, Kiechl S. Prevalence and risk factors of asymptomatic extracranial carotid artery atherosclerosis. Arterioscler Thromb. 1993;13: 661-668.
13. Kiechl S, Willeit J, Egger G, Poewe W, Oberhollenzer F. Body iron stores and the risk of carotid atherosclerosis. Circulation. 1997;96:3300-3307.
14. Schett G, Xu Q, Amberger A, Van der Zee R, Recheis H, Willeit J, Wick G. Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J Clin Invest. 1995;96:2569-2577.
15. Wick G, Romen M, Amberger A, Metzler B, Mayr M, Falkensammer G, Xu Q. Atherosclerosis, autoimmunity and vascular-associated lymphoid tissue. FASEB J. 1997;11:1199-1207.
16. Schoel B, Kaufmann SHE. The unique role of heat shock proteins in infections. In: van Eden W, Young DB, eds. Stress Proteins in Medicine. New York, NY: Marcel Dekker; 1996:27-51.
17. Bartz SR, Pauza CD, Ivanyi J, Jindal S, Welch WJ, Malkowsky M. An Hsp60 related protein is associated with purified HIV and SIV. J Med Primatol. 1994;23:151-154.
18. Schattner A, Rager-Zisman B, Virus-induced autoimmunity. Rev Infect Dis. 1990;12:204-222.
19. Coulie PG, van Snick J. Rheumatoid factor production during anamnestic immune responses in the mouse. J Exp Med. 1985;161:88-97.
20. Xu Q, Schett G, Seitz CS, Hu Y, Gupta RS, Wick G. Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells. Circ Res. 1994;75:1078-1085.
21. Soltys BJ, Gupta RS. Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells. Exp Cell Res. 1996;222:16-27.
22. Yamaguchi H, Osaki T, Taguchi H, Hanawa T, Yamamoto T, Kamiya S. Flow cytometric analysis of the heat shock protein 60 expressed on the cell surface of Helicobacter pylori. J Med Microbiol. 1996;45:270-277.
23. Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet. 1994; 344:793-795.
24. Amberger A, Maczek C, Jürgens G, Michaelis D, Schett G, Trieb K, Eberl T, Jindal S, Xu Q, Wick G. Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial and venous endothelial cells in response to cytokines and oxidized low-density lipoproteins. Cell Stress Chaperones. 1997;2:94-103.
25. Xu Q, Wick G. The role of heat shock proteins in protection and pathophysiology of the arterial wall. Mol Med Today. 1996;2:372-379.
26. Kleindienst R, Xu Q, Willeit J, Waldenberger FR, Weimann S, Wick G Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing α/β or γ/δ receptor in human atherosclerotic lesions. Am J Pathol. 1993;142:1927-1937.
27. Xu Q, Luef G, Weimann S, Gupta RS, Wolf H, Wick G. Staining of endothelial cells and macrophages in atherosclerotic lesions with human heat-shock protein-reactive antisera. Arterioscler Thromb. 1993;13: 1763-1769.
28. Schett G, Metzler B, Mayr M, Amberger A, Niederwieser D, Gupta RS, Mizzen L, Xu Q, Wick G. Macrophage-lysis mediated by autoantibodies to heat shock protein 65/60. Atherosclerosis. 1997;128:27-38.
29. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
30. Beatty WL, Byrne GI, Morrison RP. Morphologic and antigenic characterization of interferon γ-mediated persistent Chlamydia trachomatis infection in vitro. Proc Natl Acad Sci U S A. 1993;90:3998-4002.
31. Kol A, Sukhova GK, Lichtman AH, Libby P. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-α and matrix metalloproteinase expression. Circulation. 1998;98:300-307.
32. Morrison RP, Belland RJ, Lyng K, Caldwell HD. Chlamydial disease pathogenesis. The 57-kD Chlamydial hypersensitivity antigen is a stress response protein. J Exp Med. 1989;170:1271-1283.