Development of a new type of allosteric modulator of muscarinic receptors: Hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84

Journal of Medicinal Chemistry

Volumn 47, Issue 12, 2004, Pages 3324-3327

  Mohr, Marion ^b   Heller, Eberhard ^a   Ataie, Ameneh ^b   Mohr, Klaus ^b   Holzgrabe, Ulrike ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 HEXAMETHYLENEBIS[DIMETHYL(3 PHTHALIMIDOPROPYL)AMMONIUM BROMIDE]; AMINE; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR ANTAGONIST; N [2 [2 (DIPROPYLAMINOMETHYL) 1 PIPERIDYL]ETHYL] 5,11 DIHYDRO 6 OXO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPINE 11 CARBOXAMIDE;

ALLOSTERISM; ARTICLE; BINDING SITE; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; ANIMALS; GUINEA PIGS; MUSCARINIC ANTAGONISTS; MYOCARDIUM; PHTHALIMIDES; PIRENZEPINE; RADIOLIGAND ASSAY; RECEPTORS, MUSCARINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 2542637961     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031095t     Document Type: Article

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