Reversal of cystic fibrosis phenotype in a cultured Δ508 cystic fibrosis, transmembrane conductance regulator cell line by oligonucleotide insertion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 21, 2004, Pages 8150-8155

  Zamecnik, Paul C ^a   Raychowdhury, Malay K ^a   Tabatadze, David R ^a   Cantiello, Horacio F ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Functional restoration; mRNA repair; Tissue culture

Indexed keywords

CHLORIDE ION; CYCLIC AMP; OLIGONUCLEOTIDE; PHENYLALANINE; RNA; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYSTIC FIBROSIS; GENE AMPLIFICATION; GENE INSERTION; GENE MUTATION; GENETIC DISORDER; GENOTYPE; HUMAN; HUMAN CELL; MEMBRANE CHANNEL; MOUSE; NONHUMAN; PATCH CLAMP; PHENOTYPE; PHOTOCHEMICAL QUENCHING; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; TISSUE CULTURE;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GENOTYPE; HUMANS; MICE; MUTAGENESIS, INSERTIONAL; OLIGODEOXYRIBONUCLEOTIDES; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION;

ANIMALIA; INSERTION SEQUENCES;

EID: 2542626706     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0401933101     Document Type: Article

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