Morphine tolerance and dependence in the nociceptin receptor knockout mice

Journal of Neural Transmission

Volumn 108, Issue 12, 2001, Pages 1349-1361

  Mamiya, T ^a,b   Noda, Y ^a   Ren, X ^a   Nagai, T ^a   Takeshima, H ^c   Ukai, M ^b   Nabeshima, T ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MEIJO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

cAMP; Knockout mouse; Morphine; Naloxone benzoylhydrazone; Nociceptin receptor; Tolerance and dependence

Indexed keywords

CYCLIC AMP; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; NALOXONE BENZOYLHYDRAZONE; NOCICEPTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG TOLERANCE; DRUG WITHDRAWAL; JUMPING; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE STRAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; THALAMUS;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CYCLIC AMP; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; MICE; MICE, KNOCKOUT; MORPHINE; MORPHINE DEPENDENCE; MOTOR ACTIVITY; NALOXONE; NARCOTIC ANTAGONISTS; PAIN; PAIN MEASUREMENT; RADIOLIGAND ASSAY; RECEPTORS, OPIOID; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0035666475     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020100012     Document Type: Article

References (44)

1. Immunohistochemical localization of ORL-1 in the central nervous system of the rat
2. After chronic opioid exposure sensory neurons become supersensitive to the excitatory effects of opioid agonists and antagonists as occurs after acute elevation of GM1 ganglioside
3. Orphanin FQ/nociceptin: A role in pain and analgesia, but so much more
4. Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ
5. Nociceptin stimulates locomotion and exploratory behavior in mice
6. Pharmacological actions of a novel mixed opiate agonist/antagonist: Naloxone benzoylhydrazone
7. 3H] dopa in various regions of the brain
8. Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography
9. A selective phosphodiesterase 4 inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice
10. Opiate tolerance and dependence: Receptors, G-proteins and antiopiates
11. The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ
12. Effects of cyclic nucleotides and phosphodiesterase inhibition on morphine tolerance and physical dependence
13. A mu-opioid receptor-filter assay. Rapid estimation of binding affinity of ligands and reversibility of long-lasting ligand-receptor complexes
14. Cellular and molecular mechanisms of drug dependence
15. Role of different brain structures in the expression of the physical morphine withdrawal syndrome
16. Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice
17. Nociceptin system plays a role in the memory retention: Involvement of naloxone benzoylhydrazone binding sites
18. Involvement of cyclic AMP systems in morphine physical dependence in mice: Prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor
19. Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors
20. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene
21. Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor
22. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
23. Orphanin FQ is a functional anti-opioid peptide
24. Functional antaginism of mu-, delta- and kappa-opioid antinociception by orphanin FQ
25. Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain
26. Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered mu-opioid receptor agonist in the mouse
27. Molecular mechanisms of drug addiction
28. Under siege: The brain on opiates
29. Unstrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphanin FQ receptor
30. Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice
31. Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice
32. A neuropeptide that activates an opioid like G protein-coupled receptor
33. Naloxone sensitive orphanin FQ-induced analgesia in mice
34. Pharmacological characterization of orphanin FQ/nociceptin and its fragments
35. Cholera toxin-A subunit blocks opioid excitatory effects on sensory neuron action potentials indicating mediation by Gs-linked opioid receptors
36. A general role for adaptations in G-proteins and the cyclic AMP systems in mediating the chronic actions of morphine and cocaine on neuronal function
37. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: Antagonism in brain and potentiation in spinal cord of the rat
38. Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia
39. Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene
40. Quantitive aspects of precipitated abstinence in morphine-dependent rats
41. Role of nitric oxide and cyclic GMP in the dizocilpine-induced impairment of spontaneous alternation behavior in mice
42. Mu opioid receptor phosphorylation, desensitization, and ligand efficacy
43. Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters