Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene

Genomics

Volumn 45, Issue 1, 1997, Pages 185-193

  Moates, J Michael ^a   Postic, Catherine ^a   Decaux, Jean Francois ^b   Girard, Jean ^b   Magnuson, Mark A ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Ctr Rech sur l'Endocrinol M   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DNA DETERMINATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE LOCUS; HAPLOTYPE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCREENING; SINGLE STRAND CONFORMATION POLYMORPHISM; TISSUE SPECIFICITY;

EID: 0031259747     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.4936     Document Type: Article

References (54)

1. Agius, L., and Peak, M. (1993). Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin. Biochem. J. 296: 785-796.
2. Andrikopoulos, S., Rosella, G., Gaskin, E., Thorburn, A., Kaczmarczyk, S., Zajac, J. D., and Prorietto, J. (1993). Impaired regulation of hepatic fructose-1,6-bisphosphatase in the New Zealand Obese mouse model of NIDDM. Diabetes 42: 1731-1736.
3. Bali, D., Svetlanov, A., Lee, H., Fusco-DeMane, D., Leiser, M., Li, B., Barzilai, N., Surana, M., Hou, H., Fleischer, N., DePinho, R., Rossetti, L., and Efrat, S. (1995). Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J. Biol. Chem. 270: 21464-21467.
4. Bossard, P., Parsa, R., Decaux, J.-F., Iynedjian, P., and Girard, J. (1993). Glucose admistration induces the premature expression of liver glucokinase gene in newborn rats: Relation with DNAse-I-hypersensitive sites. Eur. J. Biochem. 215: 883-892.
5. Brown, K. S., Kalinowski, S. S., Megill, J. R., Durham, S. K., and Mookhtiar, K. A. (1997). Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus. Diabetes 46: 179-185.
6. Byrne, M., Sturis, J., Clement, K., Vionnet, N., Pueyo, M., Stoffel, M., Takeda, J., Passa, P., Cohen, D., Bell, G., Velho, G., Froguel, P., and Polonsky, K. (1994). Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J. Clin. Invest. 93: 1120-1130.
7. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
8. Coleman, D. L. (1977). Genetic control of glucokinase activity in mice. Biochem. Genet. 15: 297-305.
9. Coleman, D. L., and Kuzava, J. E. (1991). Genetic regulation of malic enzyme activity in the mouse. J. Biol. Chem. 266: 21997-22002.
10. Danielson, P. E., Forss-Petter, S., Brow, M. A., Calavetta, L., Douglass, J., Milner, R. J., and Sutcliffe, J. G. (1988). p1B15: A cDNA clone of the rat mRNA encoding cyclophilin. DNA 7: 261-267.
11. Dietrich, W. F., Miller, J., Steen, R., Merchant, M. A., Damron-Boles, D., Husain, Z., Dredge, R., Daly, M. J., Ingalls, K. A., O'Connor, T. J., Evans, C. A., DeAngelis, M. M., Levinson, D. M., Kruglyak, L., Goodman, N., Copeland, N. G., Jenkins, N. A., Hawkins, T. L., Stein, L., Page, D. C., and Lander, E. S. (1996). A comprehensive genetic map of the mouse genome. Nature 380: 149-152.
12. Doiron, B., Cuif, M.-H., Chen, R., and Kahn, A. (1996). Transcriptional glucose signaling through the glucose response element is mediated by the pentose phosphate pathway. J. Biol. Chem. 271: 5321-5324.
13. Fajans, S. S. (1990). Scope and heterogeneous nature of MODY. Diabetes Care 13: 49-64.
14. Ferre, T., Pujol, A., Riu, E., Bosch, F., and Valera, A. (1996). Correction of diabetic alterations by glucokinase. Proc. Natl. Acad. Sci. USA 93: 7225-7230.
15. Froguel, P., Zouali, H., Vionnet, N., Velho, G., Vaxillaire, M., Sun, F., Lesage, S., Stoffel, M., Takeda, J., Passa, P., Permutt, M. A., Beckman, J. S., Bell, G. I., and Cohen, D. (1993). Familial hyperglycemia due to mutations in glucokinase. N. Engl. J. Med. 328: 697-702.
16. Gidh-Jain, M., Takeda, J., Xu, L. Z., Lange, A. J., Vionnet, N., Stoffel, M., Froguel, P., Velho, G., Sun, F., Cohen, D., Patel, P., Lo, Y.-M. D., Hattersley, A. T., Luthman, H., Wedell, A., Charles, R. S., Harrison, R. W., Weber, I. T., Bell, G. I., and Pilkis, S. J. (1993). Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: Implications for structure/function relationships. Proc. Natl. Acad. Sci. USA 90: 1932-1936.
17. Grosveld, F., Blom Van Assendelft, G., Greaves, D. R., and Kollias, G. (1987). Position independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51: 975-985.
18. Grupe, A., Hultgren, B., Ryan, A., Ma, Y. H., Bauer, M., and Stewart, T. A. (1995). Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis. Cell 83: 69-78.
19. Hariharan, N., Farrelly, D., Hagan, D., Hillyer, D., Arbeeny, C., Sabrah, T., Treloar, A., Brown, K., Kalinowski, S., and Mookhtiar, K. (1997). Expression of human hepatic glucokinase in transgenic mice liver results in decreased glucose levels and reduced body weight. Diabetes 46: 11-16.
20. Hearne, C. M., Ghosh, S., and Todd, J. A. (1992). Microsatellites for linkage analysis of genetic traits. Trends Genet. 8: 288-294.
21. Hoffman, E. K., Trusko, S. P., Murphy, M., and George, D. L. (1990). An S1 nuclease-sensitive homopurine/homopyrimidine domain in the c-Ki-ras promoter interacts with a nuclear factor. Proc. Natl. Acad. Sci. USA 87: 2705-2709.
22. Ip, Y. T., Poon, D., Stone, D., Granner, D. K., and Chalkley, R. (1990). Interaction of a liver-specific factor with an enhancer 4.8 kb upstream of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 10: 3770-3781.
23. Iynedjian, P. B., Marie, S., Wang, H., Gjinovci, A., and Nazaryan, K. (1996). Liver-specific enhancer of the glucokinase gene. J. Biol. Chem. 271: 29113-29120.
24. James, P. A., Lavender, F. L., Lawrence, G. M., and Walker, D. G. (1985). Comparison of glucokinase in C3H/He and C58 mice that differ in their hepatic activity. Biochem. Genet. 23: 525-538.
25. Jetton, T. L., Liang, Y., Pettepher, C. C., Zimmerman, E. C., Cox, F. G., Horvath, K., Matchinsky, F. M., and Magnuson, M. A. (1994). Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J. Biol. Chem. 269: 3641-3654.
26. Kashi, Y., King, D., and Soller, M. (1997). Simple sequence repeats as a source of quantitative genetic variation. Trends Genet. 13: 74-78.
27. Kennedy, G. C., German, M. S., and Rutter, W. J. (1995). The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nature Genet. 9: 293-298.
28. Lavender, F. L., James, P. A., and Walker, D. G. (1983). Hepatic glucokinase activity and circulating insulin concentrations in two inbred mouse strains. Diabetologia 25: 114-119.
29. Leiter, E. H., and Frankel, W. N. (1993). The glucokinase (GK) gene maps to mouse chromosome 11. Mouse Genome 91: 127-129.
30. Liang, Y., Kesavan, P., Wang, L., Niswender, K., Tanizawa, Y., Permutt, M. A., Magnuson, M. A., and Matschinsky, F. M. (1995). Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme. Biochem. J. 309: 167-173.
31. Liu, Q., and Sommer, S. S. (1995). Restriction endonuclease finger-printing (REF): A sensitive method for screening mutations in long, contiguous segments of DNA. Biotechniques 18: 470-477.
32. Magnuson, M. A. (1990). Glucokinase gene structure: Functional implications of molecular genetic studies. Diabetes 39: 523-527.
33. Magnuson, M. A., Andreone, T. L., Printz, R. L., Koch, S., and Granner, D. K. (1989). Rat glucokinase gene: Structure and regulation by insulin. Proc. Natl. Acad. Sci. USA 86: 4838-4842.
34. Magnuson, M. A., Niswender, K. D., and Pettepher, C. C. (1994). Glucokinase gene expression and regulation. In "Molecular Biology of Diabetes, Part I" (B. Draznin and D. LeRoith, Eds.), pp. 155-174, Humana Press, Totowa, NJ.
35. Magnuson, M. A., and Shelton, K. D. (1989). An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. J. Biol. Chem. 264: 15936-15942.
36. Matschinsky, F., Liang, Y., Kesavan, P., Wang, L., Froguel, P., Velho, G., Cohen, D., Permutt, M. A., Tanizawa, Y., Jetton, T. L., Niswender, K., and Magnuson, M. A. (1993). Glucokinase as pancreatic β cell glucose sensor and diabetes gene. J. Clin. Invest. 92: 2092-2098.
37. Meyer, S., Hoppner, W., and Seitz, H. J. (1991). Transcriptional and post-transcriptional effects of glucose on liver phosphoenolpyruvate-carboxykinase gene expression. Eur. J. Biochem. 202: 985-991.
38. Middleton, R. J., and Walker, D. G. (1992). A comparison of hepatic glucokinase gene expression in high-and low-activity strains of mice. Comp. Biochem. Physiol. 1025: 337-342.
39. n sequences upstream of the rat prolactin gene form Z-DNA and inhibit gene transcription. Nucleic Acids Res. 18: 1595-1601.
40. Niswender, K. D., Postic, C., Shiota, M., Jetton, T. L., and Magnuson, M. A. (1997a). Effects of altered glucokinase gene copy number on blood glucose homeostasis. Biochem. Soc. Trans. 25: 113-117.
41. Niswender, K. D., Shiota, M., Postic, C., Cherrington, A. D., and Magnuson, M. A. (1997b). Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J. Biol. Chem., in press.
42. Orita, M., Iwahana, H., Kanazawa, H., Hayashi, K., and Sekiya, T. (1989a). Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl. Acad. Sci. USA 86: 2766-2770.
43. Orita, M., Suzuki, Y., Sekiya, T., and Hayashi, K. (1989b). Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5: 874-879.
44. Postic, C., Niswender, K. D., Decaux, J.-F., Parsa, R., Shelton, K. D., Gouhot, B., Pettepher, C. K., Granner, D., Girard, J., and Magnuson, M. A. (1995). Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites. Genomics 29: 740-750.
45. Printz, R. L., Magnuson, M. A., and Granner, D. K. (1993). Mammalian glucokinase. Annu. Rev. Nutr. 13: 463-496.
46. Struhl, K. (1985). Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast. Proc. Natl. Acad. Sci. USA 82: 8419-8423.
47. Tanizawa, Y., Matsutani, A., Chiu, K. C., and Permutt, M. A. (1992). Human glucokinase gene: Isolation, structural characterization, and identification of a microsatellite repeat polymorphism. Mol. Endocrinol. 6: 1070-1081.
48. Tautz, D., and Schlotterer, C. (1994). Simple sequences. Curr. Opin. Gen. Dev. 4: 832-837.
49. Terauchi, Y., Sakara, H., Yasudfa, K., Iwamoto, K., Takahashi, N., Ito, K., Kasai, H., Suzuki, H., Ueda, O., Kamada, N., Jishage, K., Komeda, K., Noda, M., Kanazawa, Y., Taniguchi, S., Miwa, I., Adanuma, Y., Kodama, T., Yazaki, Y., and Kadowaki, T. (1995). Pancreatic β-cell-specific targeted disruption of glucokinase gene: Diabetes mellitus due to defective insulin secretion to glucose. J. Biol. Chem. 270: 30253-30256.
50. Towle, H. C., Kaytor, E. N., and Shih, H.-M. (1996). Metabolic regulation of hepatic gene expression. Biochem. Soc. Trans. 24: 364-368.
51. VanSchaftingen, E. (1994). Short-term regulation of glucokinase. Diabetologia 37: s43-s47.
52. Vaulont, S., and Kahn, A. (1994). Transcriptional control of metabolic regulation genes by carbohydrates. FASEB J. 8: 28-35.
53. Velho, G., Froguel, P., Clement, K., Pueyo, M. E., Rakotoambinina, B., Zouali, H., Passa, P., Cohen, D., and Robert, J.-J. (1992). Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet 340: 444-448.
54. Vionnet, N., Stoffel, M., Takeda, J., Yasuda, K., Bell, G. I., Zouali, H., Sesage, S., Lesage, S., Velho, G., Iris, F., Passa, P., Froguel, P., and Cohen, D. (1992). Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature 356: 721-722.