메뉴 건너뛰기




Volumn 22, Issue 5, 2004, Pages 883-886

Tranilast and hypertensive heart disease: Further insights into mechanisms of an anti-inflammatory and anti-fibrotic drug

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIINFLAMMATORY AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; TRANILAST;

EID: 2542503534     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200405000-00006     Document Type: Editorial
Times cited : (17)

References (49)
  • 1
    • 0017180544 scopus 로고
    • Pharmacological properties of N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′), a new anti-atopic agent
    • Azuma H, Banno K, Yoshimura T. Pharmacological properties of N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′), a new anti-atopic agent. Br J Pharmacol 1976; 58:483-488.
    • (1976) Br J Pharmacol , vol.58 , pp. 483-488
    • Azuma, H.1    Banno, K.2    Yoshimura, T.3
  • 2
    • 0026452457 scopus 로고
    • The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts
    • Suzawa H, Kikuchi S, Arai N, Koda A. The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. Jpn J Pharmacol 1992; 60:91-96.
    • (1992) Jpn J Pharmacol , vol.60 , pp. 91-96
    • Suzawa, H.1    Kikuchi, S.2    Arai, N.3    Koda, A.4
  • 3
    • 0030986203 scopus 로고    scopus 로고
    • Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast
    • Shigeki S, Murakami T, Yata N, Ikuta Y. Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast. Scand J Plast Reconstr Surg Hand Surg 1997; 31:151-158.
    • (1997) Scand J Plast Reconstr Surg Hand Surg , vol.31 , pp. 151-158
    • Shigeki, S.1    Murakami, T.2    Yata, N.3    Ikuta, Y.4
  • 4
    • 0021806837 scopus 로고
    • The inhibition mechanism of histamine release by N-(3,4- dimethoxycinnamoyl) anthranilic acid
    • Koda A, Kurashina Y, Nakazawa M. The inhibition mechanism of histamine release by N-(3,4-dimethoxycinnamoyl) anthranilic acid. Int Arch Allergy Appl Immunol 1985; 77:244-245.
    • (1985) Int Arch Allergy Appl Immunol , vol.77 , pp. 244-245
    • Koda, A.1    Kurashina, Y.2    Nakazawa, M.3
  • 5
    • 0018719291 scopus 로고
    • A double blind controlled trial of N-(3′, 4′- dimethoxycinnamoyl) anthranilic acid on children with bronchial asthma
    • N-5′ Study Group in Children.
    • Shioda H. A double blind controlled trial of N-(3′, 4′-dimethoxycinnamoyl) anthranilic acid on children with bronchial asthma. N-5′ Study Group in Children. Allergy 1979; 34:213-219.
    • (1979) Allergy , vol.34 , pp. 213-219
    • Shioda, H.1
  • 6
    • 0021220711 scopus 로고
    • A clinical evaluation of N-5′ with perennial-type allergic rhinitis - A test by the multi-clinic, intergroup, double-blind comparative method
    • Okuda M, Ishikawa T, Saito Y, Shimizu T, Baba S. A clinical evaluation of N-5′ with perennial-type allergic rhinitis - a test by the multi-clinic, intergroup, double-blind comparative method. Ann Allergy 1984; 53:178-185.
    • (1984) Ann Allergy , vol.53 , pp. 178-185
    • Okuda, M.1    Ishikawa, T.2    Saito, Y.3    Shimizu, T.4    Baba, S.5
  • 7
    • 0036645337 scopus 로고    scopus 로고
    • Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction, in pressure-overloaded rats
    • Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, Imaizumi T. Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction, in pressure-overloaded rats. Circulation 2002; 106:130-135.
    • (2002) Circulation , vol.106 , pp. 130-135
    • Kuwahara, F.1    Kai, H.2    Tokuda, K.3    Kai, M.4    Takeshita, A.5    Egashira, K.6    Imaizumi, T.7
  • 8
    • 0030583595 scopus 로고    scopus 로고
    • Inhibitory effect of tranilast on activation and transforming growth factor beta 1 expression in cultured rat stellate cells
    • Ikeda H, Inao M, Fujiwara K. Inhibitory effect of tranilast on activation and transforming growth factor beta 1 expression in cultured rat stellate cells. Biochem Biophys Res Commun 1996; 227:322-327.
    • (1996) Biochem Biophys Res Commun , vol.227 , pp. 322-327
    • Ikeda, H.1    Inao, M.2    Fujiwara, K.3
  • 9
    • 0033711984 scopus 로고    scopus 로고
    • Reduction in left ventricular messenger RNA for transforming growth factor beta(1) attenuates left ventricular fibrosis and improves survival without lowering blood pressure in the hypertensive TGR (mRen2)27 rat
    • Pinto YM, Pinto-Sietsma SJ, Philipp T, Engler S, Kossamehl P, Hocher B, et al. Reduction in left ventricular messenger RNA for transforming growth factor beta(1) attenuates left ventricular fibrosis and improves survival without lowering blood pressure in the hypertensive TGR (mRen2)27 rat. Hypertension 2000; 36:747-754.
    • (2000) Hypertension , vol.36 , pp. 747-754
    • Pinto, Y.M.1    Pinto-Sietsma, S.J.2    Philipp, T.3    Engler, S.4    Kossamehl, P.5    Hocher, B.6
  • 10
    • 0036072237 scopus 로고    scopus 로고
    • Tranilast prevents activation of transforming growth factor-beta system, leukocyte accumulation, and neointimal growth in porcine coronary arteries after stenting
    • Ward MR, Agrotis A, Kanellakis P, Hall J, Jennings G, Bobik A. Tranilast prevents activation of transforming growth factor-beta system, leukocyte accumulation, and neointimal growth in porcine coronary arteries after stenting. Arterioscler Thromb Vasc Biol 2002; 22:940-948.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 940-948
    • Ward, M.R.1    Agrotis, A.2    Kanellakis, P.3    Hall, J.4    Jennings, G.5    Bobik, A.6
  • 11
    • 0032055716 scopus 로고    scopus 로고
    • Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries
    • Ward MR, Sasahara T, Agrotis A, Dilley RJ, Jennings GL, Bobik A. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Atherosclerosis 1998; 137:267-275.
    • (1998) Atherosclerosis , vol.137 , pp. 267-275
    • Ward, M.R.1    Sasahara, T.2    Agrotis, A.3    Dilley, R.J.4    Jennings, G.L.5    Bobik, A.6
  • 12
    • 2542447966 scopus 로고    scopus 로고
    • Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy
    • Mifsud S, Kelly DJ, Qi W, Zhang Y, Pollock CA, Wilkinson-Berka JL, Gilbert RE. Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy. Nephron Physiol 2003; 95:83-91.
    • (2003) Nephron Physiol , vol.95 , pp. 83-91
    • Mifsud, S.1    Kelly, D.J.2    Qi, W.3    Zhang, Y.4    Pollock, C.A.5    Wilkinson-Berka, J.L.6    Gilbert, R.E.7
  • 13
    • 0029762995 scopus 로고    scopus 로고
    • Antiproliferative and c-myc mRNA suppressive effect of tranilast on newborn human vascular smooth muscle cells in culture
    • Miyazawa K, Hamano S, Ujiie A. Antiproliferative and c-myc mRNA suppressive effect of tranilast on newborn human vascular smooth muscle cells in culture. Br J Pharmacol 1996; 118:915-922.
    • (1996) Br J Pharmacol , vol.118 , pp. 915-922
    • Miyazawa, K.1    Hamano, S.2    Ujiie, A.3
  • 14
    • 0029870944 scopus 로고    scopus 로고
    • Tranilast suppresses intimai hyperplasia in the balloon injury model and cuff treatment model in rabbits
    • Fukuyama J, Ichikawa K, Miyazawa K, Hamano S, Shibata N, Ujiie A. Tranilast suppresses intimai hyperplasia in the balloon injury model and cuff treatment model in rabbits. Jpn J Pharmacol 1996; 70:321-327.
    • (1996) Jpn J Pharmacol , vol.70 , pp. 321-327
    • Fukuyama, J.1    Ichikawa, K.2    Miyazawa, K.3    Hamano, S.4    Shibata, N.5    Ujiie, A.6
  • 15
    • 0033582960 scopus 로고    scopus 로고
    • Tranilast inhibits vascular smooth muscle cell growth and intimal hyperplasia by induction of p. 21 (waf1/cip1/sdi1) and p53
    • Takahashi A, Taniguchi T, Ishikawa Y, Yokoyama M. Tranilast inhibits vascular smooth muscle cell growth and intimal hyperplasia by induction of p. 21 (waf1/cip1/sdi1) and p53. Circ Res 1999; 84:543-550.
    • (1999) Circ Res , vol.84 , pp. 543-550
    • Takahashi, A.1    Taniguchi, T.2    Ishikawa, Y.3    Yokoyama, M.4
  • 16
    • 0036528804 scopus 로고    scopus 로고
    • Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension
    • Hocher B, Godes M, Olivier J, Weil J, Eschenhagen T, Slowinski T, et al. Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension. J Hypertens 2002; 20:745-751.
    • (2002) J Hypertens , vol.20 , pp. 745-751
    • Hocher, B.1    Godes, M.2    Olivier, J.3    Weil, J.4    Eschenhagen, T.5    Slowinski, T.6
  • 18
    • 0037399612 scopus 로고    scopus 로고
    • Effects of fibroblast growth inhibitor on proliferation and metastasis of oral squamous cell carcinoma
    • Noguchi N, Kawashiri S, Tanaka A, Kato K, Nakaya H. Effects of fibroblast growth inhibitor on proliferation and metastasis of oral squamous cell carcinoma. Oral Oncol 2003; 39:240-247.
    • (2003) Oral Oncol , vol.39 , pp. 240-247
    • Noguchi, N.1    Kawashiri, S.2    Tanaka, A.3    Kato, K.4    Nakaya, H.5
  • 19
    • 0030844133 scopus 로고    scopus 로고
    • Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo
    • Isaji M, Miyata H, Ajisawa Y, Takehana Y, Yoshimura N. Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br J Pharmacol 1997; 122:1061-1066.
    • (1997) Br J Pharmacol , vol.122 , pp. 1061-1066
    • Isaji, M.1    Miyata, H.2    Ajisawa, Y.3    Takehana, Y.4    Yoshimura, N.5
  • 20
    • 0036924727 scopus 로고    scopus 로고
    • Tranilast inhibits the proliferation of uterine leiomyoma cells in vitro through G1 arrest associated with the induction of p21 (waf1) and p53
    • Shime H, Kariya M, Orii A, Momma C, Kanamori T, Fukuhara K, Kusakari T, et al. Tranilast inhibits the proliferation of uterine leiomyoma cells in vitro through G1 arrest associated with the induction of p21 (waf1) and p53. J Clin Endocrinol Metab 2002; 87:5610-5617.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5610-5617
    • Shime, H.1    Kariya, M.2    Orii, A.3    Momma, C.4    Kanamori, T.5    Fukuhara, K.6    Kusakari, T.7
  • 21
    • 17744402795 scopus 로고    scopus 로고
    • Identification of tranilast-binding protein as 36-kDa microfibril-associated glycoprotein by drug affinity chromatography, and its localization in human skin
    • Furuichi H, Yamashita K, Okada M, Toyoshima T, Hata Y, Suzuki S, et al. Identification of tranilast-binding protein as 36-kDa microfibril-associated glycoprotein by drug affinity chromatography, and its localization in human skin. Biochem Biophys Res Commun 2000; 270:1002-1008.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 1002-1008
    • Furuichi, H.1    Yamashita, K.2    Okada, M.3    Toyoshima, T.4    Hata, Y.5    Suzuki, S.6
  • 22
    • 0034023880 scopus 로고    scopus 로고
    • Inhibitory mechanism of tranilast in human coronary artery smooth muscle cells proliferation, due to blockade of PDGF-BB-receptors
    • Watanabe S, Matsuda A, Suzuki Y, Kondo K, Ikeda Y, Hashimoto H, Umemura K. Inhibitory mechanism of tranilast in human coronary artery smooth muscle cells proliferation, due to blockade of PDGF-BB-receptors. Br J Pharmacol 2000; 130:307-314.
    • (2000) Br J Pharmacol , vol.130 , pp. 307-314
    • Watanabe, S.1    Matsuda, A.2    Suzuki, Y.3    Kondo, K.4    Ikeda, Y.5    Hashimoto, H.6    Umemura, K.7
  • 23
    • 0036362822 scopus 로고    scopus 로고
    • Tranilast slows the progression of advanced diabetic nephropathy
    • Soma J, Sugawara T, Huang YD, Nakajima J, Kawamura M. Tranilast slows the progression of advanced diabetic nephropathy. Nephron 2002; 92:693-698.
    • (2002) Nephron , vol.92 , pp. 693-698
    • Soma, J.1    Sugawara, T.2    Huang, Y.D.3    Nakajima, J.4    Kawamura, M.5
  • 24
  • 25
    • 0033514908 scopus 로고    scopus 로고
    • Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery
    • Shiota N, Okunishi H, Takai S, Mikoshiba I, Sakonjo H, Shibata N, Miyazaki M. Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery. Circulation 1999; 99:1084-1090.
    • (1999) Circulation , vol.99 , pp. 1084-1090
    • Shiota, N.1    Okunishi, H.2    Takai, S.3    Mikoshiba, I.4    Sakonjo, H.5    Shibata, N.6    Miyazaki, M.7
  • 26
    • 0036187877 scopus 로고    scopus 로고
    • The impact of tranilast on restenosis after coronary angioplasty: The Second Tranilast Restenosis Following Angioplasty Trial (TREAT-2)
    • Tamai H, Katoh K, Yamaguchi T, Hayakawa H, Kanmatsuse K, Haze K, et al. The impact of tranilast on restenosis after coronary angioplasty: the Second Tranilast Restenosis Following Angioplasty Trial (TREAT-2). Am Heart J 2002; 143:506-513.
    • (2002) Am Heart J , vol.143 , pp. 506-513
    • Tamai, H.1    Katoh, K.2    Yamaguchi, T.3    Hayakawa, H.4    Kanmatsuse, K.5    Haze, K.6
  • 28
    • 0033710415 scopus 로고    scopus 로고
    • Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis
    • Capper EA, Roshak AK, Bolognese BJ, Podolin PL, Smith T, Dewitt DL, et al. Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis. J Pharmacol Exp Ther 2000; 295:1061-1069.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 1061-1069
    • Capper, E.A.1    Roshak, A.K.2    Bolognese, B.J.3    Podolin, P.L.4    Smith, T.5    Dewitt, D.L.6
  • 29
    • 0035860445 scopus 로고    scopus 로고
    • Tranilast inhibits interleukin-1 beta-induced monocyte chemoattractant protein-1 expression in rat mesangial cells
    • Chikaraishi A, Hirahashi J, Takase O, Marumo T, Hishikawa K, Hayashi M, Saruta T. Tranilast inhibits interleukin-1 beta-induced monocyte chemoattractant protein-1 expression in rat mesangial cells. Eur J Pharmacol 2001; 427:151-158.
    • (2001) Eur J Pharmacol , vol.427 , pp. 151-158
    • Chikaraishi, A.1    Hirahashi, J.2    Takase, O.3    Marumo, T.4    Hishikawa, K.5    Hayashi, M.6    Saruta, T.7
  • 30
    • 0036784118 scopus 로고    scopus 로고
    • Tranilast inhibits cytokine-induced nuclear factor kappaB activation in vascular endothelial cells
    • Spiecker M, Lorenz I, Marx N, Darius H. Tranilast inhibits cytokine-induced nuclear factor kappaB activation in vascular endothelial cells. Mol Pharmacol 2002; 62:856-863.
    • (2002) Mol Pharmacol , vol.62 , pp. 856-863
    • Spiecker, M.1    Lorenz, I.2    Marx, N.3    Darius, H.4
  • 31
    • 0029101772 scopus 로고
    • Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers
    • Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J 1995; 9:899-909.
    • (1995) FASEB J , vol.9 , pp. 899-909
    • Collins, T.1    Read, M.A.2    Neish, A.S.3    Whitley, M.Z.4    Thanos, D.5    Maniatis, T.6
  • 32
    • 0031906550 scopus 로고    scopus 로고
    • Signal transduction through NF-kappa B
    • May MJ, Ghosh S. Signal transduction through NF-kappa B. Immunol Today 1998; 19:80-88.
    • (1998) Immunol Today , vol.19 , pp. 80-88
    • May, M.J.1    Ghosh, S.2
  • 33
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • Springer TA. Adhesion receptors of the immune system. Nature 1990; 346:425-434.
    • (1990) Nature , vol.346 , pp. 425-434
    • Springer, T.A.1
  • 34
    • 0031709643 scopus 로고    scopus 로고
    • Inhibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels
    • Tomita H, Egashira K, Kubo-Inoue M, Usui M, Koyanagi M, Shimokawa H, et al. Inhibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels. Arterioscler Thromb Vasc Biol 1998; 18:1456-1464.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 1456-1464
    • Tomita, H.1    Egashira, K.2    Kubo-Inoue, M.3    Usui, M.4    Koyanagi, M.5    Shimokawa, H.6
  • 36
    • 0033954753 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta1 in cardiovascular inflammatory changes induced by chronic inhibition of nitric oxide synthesis
    • Koyanagi M, Egashira K, Kubo-Inoue M, Usui M, Kitamoto S, Tomita H, et al. Role of transforming growth factor-beta1 in cardiovascular inflammatory changes induced by chronic inhibition of nitric oxide synthesis. Hypertension 2000; 35:86-90.
    • (2000) Hypertension , vol.35 , pp. 86-90
    • Koyanagi, M.1    Egashira, K.2    Kubo-Inoue, M.3    Usui, M.4    Kitamoto, S.5    Tomita, H.6
  • 37
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341:709-717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6
  • 38
    • 0031194295 scopus 로고    scopus 로고
    • Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts
    • Campbell SE, Katwa LC. Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol 1997; 29:1947-1958.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 1947-1958
    • Campbell, S.E.1    Katwa, L.C.2
  • 39
    • 0031814542 scopus 로고    scopus 로고
    • Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats
    • Tomita H, Egashira K, Ohara Y, Takemoto M, Koyanagi M, Katoh M, et al. Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats. Hypertension 1998; 32:273-279.
    • (1998) Hypertension , vol.32 , pp. 273-279
    • Tomita, H.1    Egashira, K.2    Ohara, Y.3    Takemoto, M.4    Koyanagi, M.5    Katoh, M.6
  • 40
    • 0023630085 scopus 로고
    • Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase
    • Laiho M, Saksela O, Keski-Oja J. Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase. J Biol Chem 1987; 262:17467-17474.
    • (1987) J Biol Chem , vol.262 , pp. 17467-17474
    • Laiho, M.1    Saksela, O.2    Keski-Oja, J.3
  • 41
    • 0025280867 scopus 로고
    • Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
    • Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990; 322:1561-1566.
    • (1990) N Engl J Med , vol.322 , pp. 1561-1566
    • Levy, D.1    Garrison, R.J.2    Savage, D.D.3    Kannel, W.B.4    Castelli, W.P.5
  • 42
    • 0033916114 scopus 로고    scopus 로고
    • Fibrosis and hypertensive heart disease
    • Weber KT. Fibrosis and hypertensive heart disease. Curr Opin Cardiol 2000; 15:264-272.
    • (2000) Curr Opin Cardiol , vol.15 , pp. 264-272
    • Weber, K.T.1
  • 43
    • 0036175568 scopus 로고    scopus 로고
    • Fibrosis, matrix metalloproteinases, and inflammation in the heart of DOCA-salt hypertensive rats: Role of ET(A) receptors
    • Ammarguellat FZ, Gannon PO, Amiri F, Schiffrin EL. Fibrosis, matrix metalloproteinases, and inflammation in the heart of DOCA-salt hypertensive rats: role of ET(A) receptors. Hypertension 2002; 39:679-684.
    • (2002) Hypertension , vol.39 , pp. 679-684
    • Ammarguellat, F.Z.1    Gannon, P.O.2    Amiri, F.3    Schiffrin, E.L.4
  • 44
    • 0033894949 scopus 로고    scopus 로고
    • Increased activity of nuclear factor-kappaB participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats
    • Kitamoto S, Egashira K, Kataoka C, Koyanagi M, Katoh M, Shimokawa H, et al. Increased activity of nuclear factor-kappaB participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats. Circulation 2000; 102:806-812.
    • (2000) Circulation , vol.102 , pp. 806-812
    • Kitamoto, S.1    Egashira, K.2    Kataoka, C.3    Koyanagi, M.4    Katoh, M.5    Shimokawa, H.6
  • 45
    • 0034920217 scopus 로고    scopus 로고
    • Experimental cardiac fibrosis: Differential time course of responses to mineralocorticoid-salt administration
    • Fujisawa G, Dilley R, Fullerton MJ, Funder JW. Experimental cardiac fibrosis: differential time course of responses to mineralocorticoid-salt administration. Endocrinology 2001; 142:3625-3631.
    • (2001) Endocrinology , vol.142 , pp. 3625-3631
    • Fujisawa, G.1    Dilley, R.2    Fullerton, M.J.3    Funder, J.W.4
  • 46
    • 0029738661 scopus 로고    scopus 로고
    • Contribution of local renin-angiotensin system to cardiac hypertrophy, phenotypic modulation, and remodeling in TGR (mRen2)27 transgenic rats
    • Ohta K, Kim S, Wanibuchi H, Ganten D, Iwao H. Contribution of local renin-angiotensin system to cardiac hypertrophy, phenotypic modulation, and remodeling in TGR (mRen2)27 transgenic rats. Circulation 1996; 94:785-791.
    • (1996) Circulation , vol.94 , pp. 785-791
    • Ohta, K.1    Kim, S.2    Wanibuchi, H.3    Ganten, D.4    Iwao, H.5
  • 47
    • 2542466164 scopus 로고    scopus 로고
    • Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats
    • Kagitani S, Ueno H, Hirade S, Takahashi T, Takata M, Inoue H. Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats. J Hypertens 2004; 22:1007-1015.
    • (2004) J Hypertens , vol.22 , pp. 1007-1015
    • Kagitani, S.1    Ueno, H.2    Hirade, S.3    Takahashi, T.4    Takata, M.5    Inoue, H.6
  • 48
    • 0034711717 scopus 로고    scopus 로고
    • Important role of local angiotensin II activity mediated via type 1 receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats
    • Usui M, Egashira K, Tomita H, Koyanagi M, Katoh M, Shimokawa H, et al. Important role of local angiotensin II activity mediated via type 1 receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats. Circulation 2000; 101:305-310.
    • (2000) Circulation , vol.101 , pp. 305-310
    • Usui, M.1    Egashira, K.2    Tomita, H.3    Koyanagi, M.4    Katoh, M.5    Shimokawa, H.6
  • 49
    • 0032553703 scopus 로고    scopus 로고
    • Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II
    • Jin D, Takai S, Shiota N, Miyazaki M. Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II. Eur J Pharmacol 1998; 361:199-205.
    • (1998) Eur J Pharmacol , vol.361 , pp. 199-205
    • Jin, D.1    Takai, S.2    Shiota, N.3    Miyazaki, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.