Antiproliferative and c-myc mRNA suppressive effects of tranilast on newborn human vascular smooth muscle cells in culture

British Journal of Pharmacology

Volumn 118, Issue 4, 1996, Pages 915-922

  Miyazawa, Keiji ^a   Hamano, Shuichiro ^a   Ujiie, Arao ^a  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

c myc; PDGF; Proliferation; PTCA; Restenosis; Tranilast; Vascular smooth muscle cells

Indexed keywords

APHIDICOLIN; CYCLOHEXIMIDE; DACTINOMYCIN; GENISTEIN; MESSENGER RNA; NICKEL CHLORIDE; PLATELET DERIVED GROWTH FACTOR BB; STAUROSPORINE; TRANILAST;

ARTICLE; CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; NEWBORN; NORTHERN BLOTTING; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA DEGRADATION; RNA SYNTHESIS; UNSCHEDULED DNA SYNTHESIS; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE;

EID: 0029762995     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15486.x     Document Type: Article

References (52)

1. AIKAWA, M., SIVAM, P.N., KURO-O, M., KIMURA, K., NAKAHARA, K., TAKEWAKI, S., UEDA, S., YAMAGUCHI, H., YAZAKI, Y., PERIASAMY, M. & NAGAI, R. (1993). Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ. Res., 73, 1000-1012.
2. AKIYAMA, T., ISHIDA, J., NAKAGAWA, S., OGAWARA, H., WATANABE, S., ITOH, N., SHIBUYA, M. & FUKAMI, Y. (1987). Genistein, a specific inhibitor of tyrosine-specific protein kinase. J. Biol. Chem., 262, 5592-5595.
3. AZUMA, H., BANNO, K. & YOSHIMURA, T. (1976). Pharmacological properties of N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′), a new anti-atopic agent. Br. J. Pharmacol., 58, 483-488.
4. BENNETT, M.R., ANGLIN, S., MCEWEN, J.R., JAGOE, R., NEWBY, A.C. & EVAN, G.I. (1994). Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides. J. Clin. Invest., 93, 820-828.
5. BIRO, S., FU, Y.M., YU, Z.X. & EPSTEIN, S.E. (1993). Inhibitory effects of antisense oligonucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration. Proc. Natl. Acad. Sci. U.S.A., 90, 654-658.
6. CHOMCZYNSKI, P. & SACCHI, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
7. CLOWES, A.W. & SCHWARTZ, S.M. (1985). Significance of quiescent smooth muscle migration in the injured rat carotid artery. Circ. Res., 56, 139-145.
8. DARTSCH, P.C., WEISS, H.D. & BETZ, E. (1990). Human vascular smooth muscle cells in culture: growth characteristics and protein pattern by use of serum-free media supplements. Eur. J. Cell. Biol., 51, 285-294.
9. DEAN, M., LEVINE, R.A., RAN, W., KINDY, Ms.., SONENSHEIN, G.E. & CAMPISI, J. (1986). Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact. J. Biol. Chem., 261, 9161-9166.
10. EDELMAN, E.R., SIMONS, M., SIROIS, M.G. & ROSENBERG, R.D. (1995). c-myc in vasculoproliferative disease. Circ. Res., 76, 176-182.
11. ELLEDGE, S.J., RICHMAN, R., HALL, F.L., WILLIAMS, R.T., LODGSON, N & HARPER, J.W. (1992). CDK2 encodes a 33kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. Proc. Natl. Acad. Sci. U.S.A., 89, 2907-2911.
12. EPSTEIN, S.E., SPEIR, E., UNGER, E.F., GUZMAN, R.J. & FINKEL, T. (1994). The basis of molecular strategies for treating coronary restenosis after angioplasty. J. Am. Coll. Cardiol., 23, 1278-1288.
13. FERNS, G.A.A., RAINES, E.W., SPRUGEL, K.H., MOTANI, A.S., REIDY, M.A. & ROSS, R. (1991). Inhibition of neointimal smooth muscle cell accumulation after angioplasty by an antibody to PDGF. Science, 253, 1129-1132.
14. FUJITA, H., SHIMOKADO, K., YUTANI, C., TAKAICHI, S., MASUDA, J. & OGATA, J. (1993). Human neonatal and adult vascular smooth muscle cells in culture. Exp. Mol. Palhol., 58, 25-39.
15. GLAGOW, S. (1994). Intimal hyperplasia, vascular modeling, and the restenosis problem. Circulation, 89, 2888-2891.
16. GROTENDORST, G.R., CHANG, T., SEPPA, H.E.J., KLEINMAN, H.K. & MARTIN, G.R. (1982). Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells. J. Cell. Physiol., 113, 261-266.
17. HANN, S.R., THOMPSON, C.B. & EISENMAN, R.N. (1985). c-myc oncogene protein synthesis is independent of cell cycle in human and avian cells. Nature, 314, 366-369.
18. HANSON, K.D., SHICHIRI, M., FOLLANSBEE, M.R & SEDIVY. J.M. (1994). Effect of c-myc expression on cell cycle progression. Mol. Cell. Biol., 14, 5748-5755.
19. IP, J.H., FUSTER, V., BADIMON, L., BADIMON, J., TAUBMAN, M.B. & CHESEBRO, J.H. (1990). Syndromes of accelerated atherosclerosis: Role of vascular injury and smooth muscle cell proliferation. J. Am. Coll. Cardiol., 15, 1667-1687.
20. JAWIEN, A., BOWEN-POPE, D.F., LINDER, V., SCHWARTZ. S.M. & CLOWES, A.W. (1992). Platelet-derived growth factor promotes smooth muscle migration and intimai thickening in a rat model of balloon angioplasty. J. Clin. Invest., 89, 507-511.
21. KELLY, K., COCHRAN, B.H., STILES, C.D. & LEDER, P (1983). Cell-specific regulation of the c-myc gene by lymphocyte antigens and platelet-derived growth factor. Cell, 35, 603-610.
22. KIMCHI, A. (1992). Cytokine triggered molecular pathways that control cell cycle arrest. J. Cell. Biochem., 50, 1-9.
23. 2+ transients are not required for platelet-derived growth factor to induce cell cycle progression of vascular smooth muscle cells in primary culture. J. Biol. Chem., 269, 9011-9018.
24. KOMATSU, H , KOJIMA, M., TSUTSUMI, N., HAMANO, S., KUSAMA, H., UJIIE, A., IKEDA, S. & NAKAZAWA, M. (1988). Study of the mechanism of inhibitory action of tranilast on chemical mediator release. Jpn. J. Pharmacol., 46, 43-51.
25. KOYAMA, N., HART, C.E. & CLOWES, A.W. (1994). Different function of the platelet-derived growth factor-α and -β receptors for the migration and proliferation of cultured baboon smooth muscle cells. Circ. Res., 75, 682-691.
26. LANGE, R.A., WILLARD, J.E. & HILLIS, L.D. (1993). Southwestern internal medicine conference: restenosis: the achilles heel of coronary angioplasty. Am. J. Med. Sci., 306, 265-275.
27. LECLERC, G., ISNER, J.M., KEARNEY, M., SIMONS, M., SAFIAN, R.D., BAIM. D.S. & WEIR, L. (1992). Evidence implicating nonmuscle myosin in restenosis: Use of in situ hybridization to analyze human vascular lesions obtained by directional atherectomy. Circulation, 85, 543-553.
28. LI, Z., ALVAI, M.Z. & MOORE, S. (1994). The proliferation of neointimal smooth muscle cells cultured from rabbit aortic expiants 15 weeks after de-endothelialization by a balloon catheter. Int. J. Exp. Pathol., 75, 169-177.
29. LIBBY, P. & O'BRIEN, K.V. (1983). Culture of quiescent arterial smooth muscle cells in a defined serum-free medium. J. Cell. Physiol., 115, 217-223.
30. MACLEOD, D.C., STRAUSS, B.H., JONG, M., ESCANED, J., UMANS, V.A., SUYLEN, R., VERKERT, A.V., FEYTER, P.J. & SERRUYS, P.W. (1994). Proliferation and extracellular matrix synthesis of smooth muscle cells cultured from human coronary atherosclerotic and restenotic lesions. J. Am. Coll. Cardiol., 23, 59-65.
31. MARCH, K.L., WILENSKY, R.L., ROESKE, R.W. & HATHAWAY, D.R. (1993). Effect of thiol protease inhibitors on cell cycle and proliferation of vascular smooth muscle cells in culture. Circ. Res., 72, 413-423.
32. MAJESKY, M.W., BENDITT, E.P. & SCHWARTZ, S.M. (1988). Expression and development at control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells. Proc. Natl. Acad. Sci. U.S.A., 85, 1524-1528.
33. MAJESKY, M.W., REIDY, M.A., BOWEN-POPE, D.E., HART, C.E., WILCOX, J.N. & SCHWARTZ, S.M. (1990). PDGF ligand and receptor gene expression during repair of arterial injury. J. Cell. Biol., 111, 2149-2158.
34. MIANO, J.M., VLASIC, N., TOTA, R.R. & STEMERMAN, M.B. (1993). Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury: a putative in vivo mechanism for autocrine growth. Arteriosclerosis Thrombosis, 13, 211-219.
35. MIYAZAWA, K., FUKUYAMA, J., MISAWA, K., HAMANO, S. & UJIIE, A. (1996). Tranilast antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells. Atherosclerosis, (in press).
36. MIYAZAWA, K., KIKUCHI, S., FUKUYAMA, J., HAMANO, S. & UJIIE, A. (1995). Inhibition of PDGF-, TFG-β1-induced collagen synthesis, migration and proliferation by tranilast in vascular smooth muscle cells from spontaneously hypertensive rats. Atherosclerosis, 118, 213-221.
37. PAZIN, M.J. & WILLIAMS, L.T. (1992). Triggering signaling cascades by receptor tyrosine kinases. Trends Biochem. Sci., 17, 374-378.
38. PUKAC, L.A., CASTELLOT, J.J., WRIGHT, T.C., CALEB, B.L. & KARNOVSKY, M.J. (1990). Heparin inhibits c-fos and c-myc mRNA expression in vascular smooth muscle cells. Cell Reg., 1, 435-443.
39. RABBITTS, T., WATSON, J., LAMOND, A., FORSTER, A., STINSON, M., EVAN, G , FISCHER, W., ATHERTTON, E., SHEPPARD, M & RABBITTS, T. (1985). c-myc gene products: c-myc mRNA and protein expression in the cell cycle. EMBO J., 4, 2009-2015.
40. RONNSTRAND, L., MORI, S., ARVIDSSON, A-K., ERIKSSON, A., WERNSTEDT, C., HELLMAN, U., CLAESSON-WELSH, L. & HELDIN, C.-H. (1992). Identification of two c-terminal autophosphorylation sites in the PDGF β receptor: involvement in the interaction with phospholipase C γ. EMBO J., 11, 3911-3919.
41. ROSS, R. (1993). The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature, 362, 801-809.
42. ROTHMAN, A., WOLNER, B., BUTTON, D. & TAYLOR, P. (1994). Immediate-early gene expression in response to hypertrophic and proliferative stimuli pulmonary arterial smooth muscle cells. J. Biol. Chem., 269, 6399-6404.
43. SHICHIRI, M., HANSON, K.D. & SEDIVY, J.M. (1993). The effects of c-myc expression on proliferation, quiescence, and G0 to G1 transition in non transformed cells. Cell Growth Differ., 4, 93-104.
44. SIMONS, M., LECLERC, G., SAFIAN, R.D., ISNER, J.M., WEIR, L. & BAIN, D.S. (1993). Relation between activated smooth-muscle cells in coronary-artery lesions and restenosis after atherectomy. N. Engl. J. Med., 328, 608-613.
45. STUDZINSKI, G.P., SHANKOVARAM, U.T., MOORE, D.C. & REDDY, P.V. (1991). Association of c-myc protein with enzymes of DNA replication in high molecular weight fractions from mammalian cells. J. Cell. Physiol., 147, 412-419.
46. SUZAWA, H., KIKLICHI, S., ARAI, N. & KODA, A. (1992). The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid libroblasts. Jpn. J. Pharmacol., 60, 91-96.
47. 2+ dependent protein kinase. Biochem. Biophys. Res. Commun., 135, 397-402.
48. THE TREAT STUDY INVESTIGATORS, (1994). The impact of tranilast on restenosis following coronary angioplasty: the Tranilast Restenosis Following Angioplasty Trial (TREAT) Circulation, 90, 1652.
49. THOMPSON, C.B., CHALLONER, P.B., NEIMAN, P.E. & GROUDINE, M. (1985). Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature, 314, 363-366.
50. TSO, J.Y., SUN, X.-H., KAO, T., REECE, K.S. & WU, R. (1985). Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexicity and molecular evolution of the gene. Nucleic Acids Res., 13, 2485-2502.
51. WILCOX, J.N., SMITH, K.M., WILLIAMS, L.T., SCHWARTZ, S.M. & GORDON, D. (1988). Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. J. Clin. Invest., 82, 1134-1143.
52. WISDOM, R. & LEE, W. (1991). The protein-codin region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors. Gene Dev., 5, 232-243.