Tranilast inhibits interleukin-1β-induced monocyte chemoattractant protein-1 expression in rat mesangial cells

European Journal of Pharmacology

Volumn 427, Issue 2, 2001, Pages 151-158

  Chikaraishi, Akihiro ^a   Hirahashi, Junichi ^a   Takase, Osamu ^a   Marumo, Takeshi ^a   Hishikawa, Keiichi ^b   Hayashi, Matsuhiko ^a   Saruta, Takao ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

MCP 1 (monocyte chemoattractant protein 1); Mesangial cell; NF B (nuclear factor B); Tranilast

Indexed keywords

CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LUCIFERASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TRANILAST;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REPRESSION; GLOMERULONEPHRITIS; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT;

ANIMALS; ANTHRANILIC ACIDS; CELLS, CULTURED; CHEMOKINE CCL2; GENE EXPRESSION REGULATION; GLOMERULAR MESANGIUM; INTERLEUKIN-1; LUCIFERASES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; RATS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER;

EID: 0035860445     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01215-8     Document Type: Article

References (43)

1. Macrophages in renal injury
2. Nuclear factor-κB - A pivotal transcription factor in chronic inflammatory diseases
3. IκBα degradation and nuclear factor-κB DNA binding are insufficient for interleukin-1β and tumor necrosis factor-α-induced κB-dependent transcription
4. Modulation of human monocyte activities by tranilast, SB252218, a compound demonstrating efficacy in restenosis
5. Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
6. Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular smooth muscle cells
7. CREB-binding protein/p300 are transcriptional coactivators of p65
8. Monocyte recruitment in cryoglobulinemic membranoproliferative glomerulonephritis: A pathogenic role for monocyte chemotactic peptide-1
9. Interleukin-1β activates c-jun NH2-terminal kinase subgroup of mitogen-activated protein kinases in mesangial cells
10. Interleukin-1β-induced cyclooxygenase expression requires activation of both c-Jun NH2-terminal kinase and p-38 MAPK signal pathways in rat mesangial cells
11. Both p38α MAPK and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1β in rat glomerular mesangial cells
12. Overexpression of truncated IκBα potentiates TNF-α-induced apoptosis in mesangial cells
13. Tranilast inhibits the effects of platelet-derived growth factor on cell proliferation and induction of nitric oxide
14. Tranilast restores cytokine-induced nitric oxide production against platelet-derived growth factor in vascular smooth muscle cells
15. The PRESTO (Prevention of restenosis with tranilast and its outcomes) protocol: A double-blind, placebo-controlled trial
16. Selective inhibition of collagen accumulation by N-(3,4-dimethoxycinnamoyl) anthranilic acid (N-5′) in granulation tissue
17. Intrarenal localization in interleukin-1β mRNA in crescentic glomerulonephritis
18. Chemokines: Chemotactic cytokines that mediate inflammation
19. Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-κB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells
20. Production of interleukin-1 by glomerular macrophages in the nephrotoxic serum nephritis
21. VLA-4 integrin cross-linking on human monocytic THP-1 cells induces tissue factor expression by mechanism involving mitogen-activated protein kinase
22. Monocyte chemoattractant protein-1 is excreted in excessive amounts in the urine of patients with lupus nephritis
23. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation
24. Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties
25. Glomerular expression of monocyte attractant protein-1 in experimental and human glomerulonephritis
26. Activation of nuclear factor-κB correlates with MCP-1 expression by human mesangial cells
27. Monocyte chemoattractant protein-1 levels in patients with glomerular disease
28. The mitogen-activated protein kinase p38 is necessary for interleukin 1β-induced monocyte chemoattractant protein 1 expression by human mesangial cells
29. Chemokines, chemokine receptors, and renal disease: From basic science to pathophysiologic and therapeutic studies
30. The cis-acting phorbol ester "12-o-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression
31. Tranilast inhibits nuclear factor-kappa B dependent expression of endothelial adhesion molecules
32. Increased expression of monocyte chemoattractant protein-1 in anti-thymocyte antibody-induced glomerulonephritis
33. c-Rel and p65 trans-activate the monocyte chemoattractant protein-1 gene in interleukin-1 stimulated mesangial cells
34. Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages
35. Impact of tranilast on restenosis after coronary angioplasty: Tranilast Restenosis Following Angioplasty Trial (TREAT)
36. Prominent inhibitory effects of tranilast on migration and proliferation of and collagen synthesis by vascular smooth muscle cells
37. Monocyte chemoattractant protein 1 mediates glomerular macrophage infiltration in anti-GBM Ab GN
38. Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-κB-dependent IL-6 expression in human monocytes
39. Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B
40. Monocyte chemoattractant protein-1 mediates monocyte/macrophage influx in anti-thymocyte antibody-induced glomerulonephritis
41. Activation of transcriptional factor NF-κB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways
42. Interleukin-1β induction of mitogen-activated protein kinase in human mesangial cells
43. In situ expression of cytokines in IgA nephritis