Role of Transforming Growth Factor-β1 in Cardiovascular Inflammatory Changes Induced by Chronic Inhibition of Nitric Oxide Synthesis

Hypertension

Volumn 35, Issue 1, 2000, Pages 86-

  Koyanagi, Masamichi ^a   Egashira, Kensuke ^a   Kubo Inoue, Mayuko ^a   Usui, Makoto ^a   Kitamoto, Shiro ^a   Tomita, Hideharu ^a   Shimokawa, Hiroaki ^a   Takeshita, Akira ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Adhesion molecule; Angiotensin II; Endothelium derived factor; Fibrosis; Growth substances; Inflammation

Indexed keywords

ANGIOTENSIN; CELL ADHESION MOLECULE; INTERCELLULAR ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN; NEUTRALIZING ANTIBODY; NITRIC OXIDE; TRANSFORMING GROWTH FACTOR BETA1;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR INFLAMMATION; FIBROSIS; HYPERCHOLESTEROLEMIA; HYPERTENSION; MALE; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; CARDIOVASCULAR DISEASES; CHEMOKINE CCL2; CORONARY VESSELS; GENE EXPRESSION; HEART; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MALE; MONOCYTES; MYOCARDIUM; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; P-SELECTIN; RATS; RATS, INBRED WKY; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033954753     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/01.HYP.35.1.86     Document Type: Article

References (29)

1. Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest. 1997; 100:2153-2157.
2. Griendling KK, Alexander RW. Endothelial control of the cardiovascular system: recent advances. FASEB J. 1996; 10:283-292.
3. Egashira K, Inou T, Hirooka Y, Yamada A, Maruoka Y, Kai H, Sugimachi M, Suzuki S, Takeshita A. Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions. J Clin Invest. 1993; 91:29-37.
4. Egashira K, Inou T, Hirooka Y, Kai H, Sugimachi M, Suzuki S, Kuga T, Urabe Y, Takeshita A. Effects of age on endothelium-dependent vasodilatation of resistance coronary artery by acetylcholine in humans. Circulation. 1993; 88:77-81.
5. Egashira K, Suzuki S, Hirooka Y, Kai H, Sugimachi M, Imaizumi T, Takeshita A. Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension. Hypertension. 1995; 25:201-206.
6. Zeiher AM, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans. J Clin Invest. 1993; 92:652-662.
7. Vita JA, Treasure CB, Nabel EG, McLenachan JM, Fish RD, Yeung AC, Vekshtein VI, Selwyn AP, Ganz P. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation. 1990; 81:491-497.
8. Takemoto M, Egashira K, Usui M, Numaguchi K, Tomita H, Tsutsui H, Shimokawa H, Sueishi K, Takeshita A. Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats. J Clin Invest. 1997; 99:278-287.
9. Takemoto M, Egashira K, Tomita H, Usui M, Okamoto H, Kitabatake A, Shimokawa H, Sueishi K, Takeshita A. Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade. Hypertension. 1997; 30:1621-1627.
10. Tomita H, Egashira K, Ohara Y, Takemoto M, Koyanagi M, Katoh M, Yamamoto H, Tamaki K, Shimokawa H, Takeshita A. Early induction of transforming growth factor-β via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats. Hypertension. 1998; 32:273-279.
11. Tomita H, Egashira K, Kubo-Inoue M, Usui M, Koyanagi M, Shimokawa H, Takeya M, Yoshimura T, Takeshita A. Inhibition of nitric oxide synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels. Arterioscler Thromb Vasc Biol. 1998; 18:1456-1464.
12. Katoh M, Egashira K, Usui M, Ichiki T, Tomita H, Shimokawa H, Rakugi H, Takeshita A. Cardiac angiotensin II receptors are upregulated by long-term inhibition of nitric oxide synthesis in rats. Circ Res. 1998; 83:743-751.
13. Luvar G, Pueyo M, Philippe M, Mandet C, Savoie F, Henrion D, Michel J-B. Chronic blockade of NO synthase activity induces a proinflammatory phenotype in the arterial wall: prevention by angiotensin II antagonism. Arterioscler Thromb Vasc Biol. 1998; 18:1408-1416.
14. Wahl SM. Transforming growth factor beta: the good, the bad, and the ugly. J Exp Med. 1994; 180:1587-1590.
15. Border WA, Ruoslahti E. Transforming growth factor-beta in disease: the dark side of tissue repair. J Clin Invest. 1992; 90:1-7.
16. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest. 1997; 100:768-776.
17. Nabel E, Shum L, Pompili V, Yang Z, San H, Shu H, Liptay S, Gold L, Gordon D, Derynck R. Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci U S A. 1993; 90:10759-10763.
18. Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, Allen R, Sidman C, Proetzel G, Calvin D, Annunziata N, Doetschman T. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature. 1992; 359:693-699.
19. Kulkarni A, Huh C, Becker D, Geiser A, Lyght M, Flanders K, Roberts A, Sporn M, Ward J, Karlsson S. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A. 1993; 90:770-774.
20. Miyazono K, Ichijo H, Heldin CH. Transforming growth factor-beta: latent forms, binding proteins and receptors. Growth Factors. 1993; 8:11-22.
21. Kim S, Ohta K, Hamaguchi A, Yukimura T, Miura K, Iwao H. Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats. Hypertension. 1995; 25:1252-1259.
22. Crawford D, Chobanian A, Brecher P. Angiotensin II induces fibronectin expression associated with cardiac fibrosis in the rat. Circ Res. 1994; 74:727-739.
23. Weber KT. Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation. Circulation. 1997; 96:4065-4082.
24. Zalewski A, Shi Y. Vascular myofibroblasts: lessons from coronary repair and remodeling. Arterioscler Thromb Vasc Biol. 1997; 17:417-422.
25. Darby I, Skalli O, Gabbiani G. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest. 1990; 63:21-29.
26. Hinglais N, Heudes D, Nicoletti A, Mandet C, Laurent M, Bariety J, Michel JB. Colocalization of myocardial fibrosis and inflammatory cells in rats. Lab Invest. 1994; 70:286-294.
27. Nicoletti A, Mandet C, Challah M, Bariety J, Michel JB. Mediators of perivascular inflammation in the left ventricle of renovascular hypertensive rats. Cardiovasc Res. 1996; 31:585-595.
28. Yoo KH, Thornhill BA, Wolstenholme JT, Chevalier RL. Tissue-specific regulation of growth factors and clustering by angiotensin II. Am J Hypertens. 1998; 11:715-722.
29. Diebold R, Eis M, Yin M, Ormsby I, Boivin G, Darrow B, Saffitz J, Doetschman T. Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. Proc Natl Acad Sci U S A. 1995; 92:12215-12219.