Contribution of local renin-angiotensin system to cardiac hypertrophy, phenotypic modulation, and remodeling in TGR(mRen2)27 transgenic rats

Circulation

Volumn 94, Issue 4, 1996, Pages 785-791

  Ohta, Kensuke ^a   Kim, Shokei ^a   Wanibuchi, Hideki ^a   Ganten, Detlev ^b   Iwao, Hiroshi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

angiotensin; genes; hypertrophy; remodeling; renin

Indexed keywords

ALPHA ACTIN; ANTIHYPERTENSIVE AGENT; ATENOLOL; ATRIAL NATRIURETIC FACTOR; CANDESARTAN HEXETIL; COLLAGEN; DOXAZOSIN; LAMININ; MANIDIPINE; MYOSIN HEAVY CHAIN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE THERAPY; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HYPERTENSION; MALE; NONHUMAN; NORTHERN BLOTTING; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENIC ANIMAL;

EID: 0029738661     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.4.785     Document Type: Article

References (50)

1. Frohlich ED. Left ventricular hypertrophy, cardiac diseases and hypertension: recent experiences. J Am Coll Cardiol. 1989;14:1587-1594.
2. Baker KM, Booz GW, Dostal DE. Cardiac actions of angiotensin II: role of an intracardiac renin-angiotensin system. Annu Rev Physiol. 1992;54:227-241.
3. Morgan HE, Baker KM. Cardiac hypertrophy: mechanical, neural, and endocrine dependence. Circulation. 1991;83:13-25.
4. Mullins JJ, Peters J, Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature. 1990;344:541-544.
5. Bader M, Zhao Y, Sander M, Lee MA, Bachmann J, Bohm M, Djavidani B, Peters J, Mullins JJ, Ganten D. Role of tissue renin in the pathophysiology of hypertension in TGR(mREN2)27 rats. Hypertension. 1992;19:681-686.
6. Ganten D, Lindpaintner K, Ganten U, Peters J, Zimmermann F, Bader M, Mullins J. Transgenic rats: new animal models in hypertension research. Hypertension. 1991;17:843-855.
7. Lee MA, Böhm M, Kim S, Bachmann S, Bachmann J, Bader M, Ganten D. Differential gene expression of renin and angiotensinogen in the TGR(mREN-2)27 transgenic rat. Hypertension. 1995;25:570-580.
8. Parker TG, Schneider MD. Growth factors, proto-oncogenes, and plasticity of the cardiac phenotype. Anna Rev Physiol. 1991;53:179-200.
9. Brilla CG, Maisch B, Weber KT. Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation. Clin Invest. 1993;71:S35-S41.
10. Ohta K, Kim S, Hamaguchi A, Yukimura T, Miura K, Takaori K, Iwao H. Role of angiotensin II in extracellular matrix and transforming growth factor-β1 in hypertensive rats. Eur J Pharmacol. 1994;269:115-119.
11. Ohta K, Kim S, Hamaguchi A, Miura K, Yukimura T, Iwao H. Cardiac hypertrophy-related gene expression in spontaneously hypertensive rats: crucial role of angiotensin AT1 receptor. Jpn J Pharmacol. 1995;67:95-99.
12. Kim S, Ohta K, Hamaguchi A, Omura T, Yukimura T, Miura K, Inada Y, Ishimura Y, Chatani F, Iwao H. Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor-β1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats. J Pharmacol Exp Ther. 1995;273:509-515.
13. Nadal-Ginard B, Mahdavi V. Molecular basis of cardiac performance: plasticity of the myocardium generated through protein isoform switches. J Clin invest. 1989;84:1693-1700.
14. Shibouta Y, Inada Y, Ojima M, Wada T, Noda M, Sanada T, Kubo K, Kohara Y, Naka T, Nishikawa K. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1 -[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7- carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole- 7-carboxylate (TCV-116). J Pharmacol Exp Ther. 1993;266:114-120.
15. Kakihana M, Suno M, Nagaoka A. Antihypertensive effect of CV-4093-2HCl, a new calcium antagonist, in three rat models of hypertension. Jpn J Pharmacol. 1988;48:223-228.
16. Timmermans PBMWM, Kwa HY, Ali FK, van Zwieten PA. Prazosin and its analogues UK-18,596 and UK-33,274: a comparative study on cardiovascular effects and alpha-adrenoceptor blocking activities. Arch Int Pharmacodyn Ther. 1980;245:218-235.
17. Richer C, Boissier JR, Giudicelli JF. Chronic atenolol treatment and hypertension development in spontaneously hypertensive rats. Eur J Pharmacol. 1978;47:393-400.
18. Ishiko J, Munehasu S, Suzuki M. Pharmacological studies on doxazosin mesilate. Oyo Yakuri. 1989;38:387-399.
19. Chichester CO, Rodgers LR. Effects of doxazosin on vascular collagen synthesis, arterial pressure and serum lipids in the spontaneously hypertensive rat. J Cardiovasc Pharmacol. 1987;10(suppl 9):S21-S26.
20. Inada Y, Wada T, Shibouta Y, Ojima M, Sanada T, Ohtsuki K, Itoh K, Kubo K, Kohara Y, Naka T, Nishikawa K. Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, (±)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole- 7-carboxylate (TCV-116), in various hypertensive rats. J Pharmacol Exp Ther. 1994;268:1540-1547.
21. Takeda K, Nakagawa Y, Chin WP, Imai S. A comparison of antihypertensive effects of atenolol and propranolol in the spontaneously hypertensive. DOC A/saline hypertensive and renal hypertensive rats. Jpn J Pharmacol. 1982;32:283-289.
22. Gustafson TA, Markham BE, Morkin E. Effects of thyroid hormone on α-actin and myosin heavy chain gene expression in cardiac and skeletal muscles of the rat: measurement of mRNA content using synthetic oligonucleotide probes. Circ Res. 1986;59:194-201.
23. Mayer Y, Czosnek H, Zeelon PE, Yaffe D, Nudel U. Expression of the genes coding for the skeletal muscle and cardiac actions in the heart. Nucleic Acids Res. 1984;12:1087-1100.
24. Kim S, Ohta K, Hamaguchi A, Yukimura T, Miura K, Iwao H. Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats. Hypertension. 1995;25:1252-1259.
25. McHugh KM, Lessard JL. The nucleotide sequence of a rat vascular smooth muscle α-actin cDNA. Nucleic Acids Res. 1988;16:4167.
26. Genovese C, Rowe D, Kream B. Construction of DNA sequences complementary to rat α1 and α2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D. Biochemistry. 1984;23:6210-6216.
27. Liau G, Yamada Y, de Crombrugghe B. Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts. J Biol Chem. 1985;260:531-536.
28. Oberbaumer I, Laurent M, Schwarz U, Sakurai Y, Yamada Y, Vogeli G, Voss T, Siebold B, Glanville RW, Kuhn K. Amino acid sequence of the non-collagenous globular domain (NC1) of the α1(IV) chain of basement membrane collagen as derived from complementary DNA. Eur J Biochem. 1985;147:217-224.
29. Sasaki M, Kato S, Kohno K, Martin GR, Yamada Y. Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats. Proc Natl Acad Sci USA. 1987;84:935-939.
30. Sasaki M, Yamada Y. The laminin B2 chain has a multidomain structure homologous to the B1 chain. J Biol Chem. 1987;262:17111-17117.
31. Fort P, Marly L, Piechaczyk M, el-Sabrouty S, Dani C, Jeanteur P, Blanchard JM. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 1985;13:1431-1442.
32. Qian SW, Kondaiah P, Roberts AB, Sporn MB. cDNA cloning by PCR of rat transforming growth factor β-1. Nucleic Acids Res. 1990;18:3059.
33. Nakayama K, Ohkubo H, Hirose T, Inayama S, Nakanishi S. mRNA sequence for human cardiodilatin-atrial natriuretic factor precursor and regulation of precursor mRNA in rat atria. Nature. 1984;310:699-701.
34. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
35. Kim S, Ohta K, Hamaguchi A, Omura T, Yukimura T, Miura K, Inada Y, Wada T, Ishimura Y, Chatani F, Iwao H. Role of angiotensin II in renal injury of deoxycorticosterone acetate-salt hypertensive rats. Hypertension. 1994;24:195-204.
36. Kim S, Tokuyama M, Hosoi M, Yamamoto K. Adrenal and circulating renin-angiotensin system in stroke-prone hypertensive rats. Hypertension. 1992;20:280-291.
37. Naruse M, Inagami T. Markedly elevated specific renin levels in the adrenal in genetically hypertensive rats. Proc Natl Acad Sci USA. 1982;79:3295-3299.
38. Dorn GW, Robbins J, Ball N, Walsh RA. Myosin heavy chain regulation and myocyte contractile depression after LV hypertrophy in aortic-banded mice. Ant J Physiol. 1994;267:H400-H405.
39. Hewett TE, Grupp IL, Grupp G, Robbins J. α-Skeletal actin is associated with increased contractility in the mouse heart. Circ Res. 1994;74:740-746.
40. Martin GR, Timpl R. Laminin and other basement membrane components. Annu Rev Cell Biol. 1987;3:57-85.
41. Parker TG, Packer SE, Schneider MD. Peptide growth factor can provoke 'fetal' contractile protein gene expression in rat cardiac myocytes. J Clin Invest. 1990;85:507-514.
42. Border WA, Ruoslahti E. Transforming growth factor-β in disease: the dark side of tissue repair. J Clin Invest. 1992;90:1-7.
43. Bachmann S, Peters J, Engler E, Ganten D, Mullins J. Transgenic rats carrying the mouse renin gene: morphological characterization of a low-renin hypertension model. Kidney Int. 1992;41:24-36.
44. Black FM, Packer SE, Parker TG, Michael LH, Roberts R, Schwartz RJ, Schneider MD. The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load. J Clin Invest. 1991;88:1581-1588.
45. Sadoshima J, Jahn L, Takahashi T, Kulik TJ, Izumo S. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. J Biol Chem. 1992;267:10551-10560.
46. Bisophiric NH, Simpson PC, Ordahl CP. Induction of the skeletal α-actin gene in α1-adrenoreceptor-mediated hypertrophy of rat cardiac myocytes. J Clin Invest. 1987;80:1194-1199.
47. Knowlton KU, Baracchini E, Ross RS, Harris AN, Henderson SA, Evans SM, Glembotski CC, Chien KR. Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells: identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. J Biol Chem. 1991;266:7759-7768.
48. Waspe LE, Ordahl CP, Simpson PC. The cardiac β-myosin heavy chain isogene is induced selectively in α1-adrenergic receptor-stimulated hypertrophy of cultured rat heart myocyte. J Clin Invest. 1990;85:1206-1214.
49. Izumo S, Nadal-Ginard B, Mahdavi V. Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci USA. 1988;85:339-343.
50. Izumo S, Lompré A-M, Matsuoka R, Koren G, Schwartz K, Nadal-Ginard B, Mahdavi V. Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy: interaction between hemodynamic and thyroid hormone-induced signals. J Clin Invest. 1987;79:970-977.