Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: Substrate specificity in UDP-hexose 4-epimerases

Journal of Biological Chemistry

Volumn 279, Issue 21, 2004, Pages 22635-22642

  Ishiyama, Noboru ^a   Creuzenet, Carole ^b   Lam, Joseph S ^c   Berghuis, Albert M ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BACTERIA; BIOSYNTHESIS; CATALYSTS; CRYSTAL STRUCTURE; MUTAGENESIS; PATHOLOGY; POLYSACCHARIDES;

ACTIVE SITES; PATHOGENIC BACTERIA; SUBSTRATE SPECIFICITY; VIRULENCE FACTORS;

BIOCHEMISTRY;

BACTERIAL ENZYME; EPIMERASE; LIPOPOLYSACCHARIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; O ANTIGEN; PROTEIN WBPP; SACCHARIDE EPIMERASE; SOLVENT; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE HEXOSE 4 EPIMERASE; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE 4 EPIMERASE; VIRULENCE FACTOR;

ARTICLE; CATALYSIS; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENETIC CONSERVATION; GRAM NEGATIVE BACTERIUM; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SEROTYPE; UNINDEXED SEQUENCE;

BINDING SITES; CARBOHYDRATE EPIMERASES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ELECTRONS; KINETICS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHYLOGENY; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); HOMO; NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 2542500431     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401642200     Document Type: Article

References (34)

1. Downey, J. S., and Han, J. (1998) Front. Biosci. 3, d468-d476
2. Du, X., Poltorak, A., Silva, M., and Beutler, B. (1999) Blood Cells Mol. Dis. 25, 328-338
3. Heumann, D., and Roger, T. (2002) Clin. Chim. Acta 323, 59-72
4. Lerouge, I., and Vanderleyden, J. (2002) FEMS Microbiol. Rev. 26, 17-47
5. Knirel, Y. A. (1990) Crit. Rev. Microbiol. 17, 273-304
6. Belanger, M., Burrows, L. L., and Lam, J. S. (1999) Microbiology 145, 3505-3521
7. Creuzenet, C., Belanger, M., Wakarchuk, W. W., and Lam, J. S. (2000) J. Biol. Chem. 275, 19060-19067
8. Bauer, A. J., Rayment, I., Frey, P. A., and Holden, H. M. (1992) Proteins 12, 372-381
9. Samuel, J., and Tanner, M. E. (2002) Nat. Prod. Rep. 19, 261-277
10. Allard, S. T., Giraud, M. F., and Naismith, J. H. (2001) Cell. Mol. Life Sci. 58, 1650-1665
11. Thoden, J. B., Wohlers, T. M., Fridovich-Keil, J. L., and Holden, H. M. (2000) Biochemistry 39, 5691-5701
12. Shaw, M. P., Bond, C. S., Roper, J. R., Gourley, D. G., Ferguson, M. A., and Hunter, W. N. (2003) Mol. Biochem. Parasitol. 126, 173-180
13. Thoden, J. B., Frey, P. A., and Holden, H. M. (1996) Biochemistry 35, 5137-5144
14. Thoden, J. B., Frey, P. A., and Holden, H. M. (1996) Biochemistry 35, 2557-2566
15. Thoden, J. B., Gulick, A. M., and Holden, H. M. (1997) Biochemistry 36, 10685-10695
16. Thoden, J. B., Hegeman, A. D., Wesenberg, G., Chapeau, M. C., Frey, P. A., and Holden, H. M. (1997) Biochemistry 36, 6294-6304
17. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
18. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
19. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard. (1991) Acta Crystallogr. Sect. A 47, 110-119
20. Janin, J. (1995) Biochimie (Paris) 77, 497-505
21. Thoden, J. B., Wohlers, T. M., Fridovich-Keil, J. L., and Holden, H. M. (2001) J. Biol. Chem. 276, 15131-15136
22. Thoden, J. B., and Holden, H. M. (1998) Biochemistry 37, 11469-11477
23. Liu, Y., Thoden, J. B., Kim, J., Berger, E., Gulick, A. M., Ruzicka, F. J., Holden, H. M., and Frey, P. A. (1997) Biochemistry 36, 10675-10684
24. Mesecar, A. D., Stoddard, B. L., and Koshland, D. E., Jr. (1997) Science 277, 202-206
25. Thoden, J. B., Henderson, J. M., Fridovich-Keil, J. L., and Holden, H. M. (2002) J. Biol. Chem. 277, 27528-27534
26. Kowal, P., and Wang, P. G. (2002) Biochemistry 41, 15410-15414
27. Lopez, A. B., Sener, K., Jarroll, E. L., and van Keulen, H. (2003) Mol. Biochem. Parasitol. 128, 51-57
28. Bengoechea, J. A., Pinta, E., Salminen, T., Oertelt, C., Holst, O., Radziejewska-Lebrecht, J., Piotrowska-Seget, Z., Venho, R., and Skurnik, M. (2002) J. Bacteriol. 184, 4277-4287
29. Soldo, B., Scotti, C., Karamata, D., and Lazarevic, V. (2003) Gene (Amst.) 319, 65-69
30. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
31. Fenn, T. D., Ringe, D., and Petsko, G. A. (2003) J. Appl. Crystallogr. 36, 944-947
32. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
33. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., and Higgins, D. G. (1997) Nucleic Acids Res. 25, 4876-4882
34. Page, R. D. (1996) Comput. Appl. Biosci. 12, 357-358