Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase

Biochemistry

Volumn 39, Issue 19, 2000, Pages 5691-5701

  Thoden, James B ^a   Wohlers, Travis M ^b   Fridovich Keil, Judith L ^b   Holden, Hazel M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TYROSINE; URIDINE DIPHOSPHATE GLUCOSE 4 EPIMERASE;

AMINO ACID ANALYSIS; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; HUMAN; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; PROTON TRANSPORT; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; NAD; PICHIA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TYROSINE; UDPGLUCOSE 4-EPIMERASE; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE GLUCOSE;

EID: 0034673977     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi000215l     Document Type: Article

References (37)

1. Alano, A., Almashanu, S., Maceratesi, P., Reichardt, J., Panny, S., and Cowan, T. M. (1997) J. Invest. Med. 45, 191A.
2. Gitzelmann, R., Steinmann B., Mitchell, B., and Haigis E., (1977) Helv. Paediatr. Acta 31, 441-452.
3. Alano, A., Almashanu, S., Chinsky, J. M., Costeas, P., Blitzer, M. G., Wulfsberg, E. A., and Cowan T. M. (1998) J. Inherited Metab. Dis. 21, 341-350.
4. Quimby, B. B., Alano, A., Almashanu, S., DeSandro, A. M., Cowan, T. M., and Fridovich-Keil, J. L. (1997) Am. J. Hum. Genet. 61, 590-598.
5. Segal, S., and Berry, G., (1995) in The Metabolic and Molecular Bases of Inherited Disease (Scriver, C., Beaudet, A., Sly, W., Valle, D., Eds.) pp 967-1000, McGraw-Hill, Inc., New York.
6. Shin, Y. S., Korenke, G.-C., Huppke, P., Knerr, I., and Podskarbi, T. (1999) J. Inherited Metab. Dis. 22 (Suppl. 1), 8.
7. Walter, J. H., Roberts, R. E., Besley, G. T., Wraith, J. E., Cleary, M. A., Holton, J. B., and MacFaul, R., (1999) Arch. Dis. Child. 80, 374-376.
8. Wohlers, T. M., Christacos, N. C., Harreman, M. T., and Fridovich-Keil, J. L. (1999) Am. J. Hum. Genet. 64, 462-470.
9. Maceratesi, P., Dallapiccola, B., Novelli, G., Okano, Y., Isshiki, G., and Reichardt, J. K. V. (1996) Am. J. Hum. Genet. 59 (Suppl.), A204.
10. Maceratesi, P., Daude, N., Dallapiccola, B., Novelli, G., Allen, R., Okano, Y., and Reichardt, J. (1998) Mol. Genet. Metab. 63, 26-30.
11. Thoden, J. B., Frey, P. A., and Holden, H. M. (1996) Protein Sci. 5, 2149-2161.
12. Thoden, J. B., Frey, P. A., and Holden, H. M. (1996) Biochemistry 35, 2557-2566.
13. Thoden, J. B., Frey, P. A., and Holden, H. M. (1996) Biochemistry 35, 5137-5144.
14. Thoden, J. B., Gulick, A. M., and Holden, H. M. (1997) Biochemistry 36, 10685-10695.
15. Thoden, J. B., and Holden, H. M. (1998) Biochemistry 37, 11469-11477.
16. Wilson, D. B., and Hogness, D. S. (1969) J. Biol. Chem. 244, 2132-2136.
17. Lemaire, H. G., and Müller-Hill, B. (1986) Nucleic Acids Res. 14, 7705-7711.
18. Liu, Y., Thoden, J. B., Kim, J., Berger, E., Gulick, A. M., Ruzicka, F. J., Holden, H. M., and Frey, P. A. (1997) Biochemistry 36, 10675-10684.
19. Baker, M. E., and Blasco, R. (1992) FEBS Lett. 301, 89-93.
20. Holm, L., Sander, C., & Murzin, A. (1994) Nat. Struct. Biol. 1, 146-147.
21. Duax, W. L., Griffin, J. F., and Ghosh, D. (1996) Curr. Opin. Struct. Biol. 6, 813-823.
22. Maley, F., and Maley, G. F. (1959) Biochim. Biophys. Acta 31, 577-578.
23. Piller, F., Hanlon, M. H., and Hill, R. L. (1983) J. Biol. Chem. 258, 10774-10778.
24. Kingsley, D., Kozarsky, K. F., Hobbie, L., and Krieger, M. (1986) Cell 44, 749-759.
25. Terwilliger, T. C., and Eisenberg, D. (1983) Acta Crystallogr., Sect. A 39, 813-817.
26. Tronrud, D. E., Ten Eyck, L. F., and Matthews, B. W. (1987) Acta Crystallogr., Sect. A. 43, 489-501.
27. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326.
28. Navaza, J. (1994) Acta Crystallogr, Sect. A 50, 157-163.
29. Jones, T. A. (1992) in Molecular Replacement (Dodson, E. J., Gover, S., and Wolf, W., Eds.) pp 91-105, SERC Daresbury Laboratory, Warrington.
30. Kleywegt, G. J., and Jones, T. A. (1994) in From First Map to Final Model (Bailey, S., Hubbard, R., and Waller, D., Eds.) pp 56-66, SERC Daresbury Laboratory, Warrington.
31. Langer, R., and Glaser, L. (1974) J. Biol. Chem. 249, 1126-1132.
32. Kang, U. G., Nolan, L. D., and Frey, P. A. (1975) J. Biol. Chem. 250, 7099-7105.
33. Bertland, A. U., II, and Kalckar, H. M. (1968) Proc. Natl. Acad. Sci. U.S.A. 61, 629-635.
34. Cleland, W. W., and Kreevoy, M. M. (1994) Science 264, 1887-1890.
35. Gerlt, J. A., and Gassman, P. G. (1993) Biochemistry 32, 11943-11952.
36. Gerlt, J. A., and Gassman, P. G. (1993) J. Am. Chem. Soc. 115, 11552-11568.
37. Ramaswamy, S., Park, D.-H., and Plapp, B. V. (1999) Biochemistry 38, 13951-13959.