The reaction mechanism of phospholipase D from Streptomyces sp. strain PMF. Snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product

Journal of Molecular Biology

Volumn 339, Issue 4, 2004, Pages 805-820

  Leiros, Ingar ^a   McSweeney, Sean ^b   Hough, Edward ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b INSTITUT LAUE LANGEVIN   (France)

Author keywords

pentacovalent phosphorus; phosphohistidine; PLC, phospholipase C; PLD, phospholipase D; PLDPMF, phospholipase D from Streptomyces sp. strain PMF; reaction mechanism; Tdp1, tyrosyl DNA phosphodiesterase; transition state; X ray crystallography

Indexed keywords

HISTIDINE DERIVATIVE; PHOSPHATIDIC ACID; PHOSPHOHISTIDINE; PHOSPHOLIPASE D; PHOSPHORUS DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES SP.;

EID: 2542488279     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.04.003     Document Type: Article

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