Agonist-independent internalization of metabotropic glutamate receptor 1a is arrestin- and clathrin-dependent and is suppressed by receptor inverse agonists

Journal of Neurochemistry

Volumn 89, Issue 4, 2004, Pages 1009-1020

  Pula, Giordano ^a   Mundell, Stuart J ^a   Roberts, Peter J ^a   Kelly, Eamonn ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

BAY36 7620; Constitutive activity; Constitutive internalization; Inverse agonist; LY367385; Metabotropic glutamate receptor 1a

Indexed keywords

4 CARBOXY 2 METHYLPHENYLGLYCINE; 6A NAPHTHALEN 2 YLMETHYL 5 METHYLIDENEHEXAHYDROCYCLOPENTANO[C]FURAN 1 ONE; 7 (HYDROXYIMINO)CYCLOPROPANO[B]CHROMENE 1A CARBOXYLIC ACID ETHYLESTER; ARRESTIN 2; BAY 367620; CARBOXYLIC ACID DERIVATIVE; CHROMENE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15; GLUTAMATE RECEPTOR 1B; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 1A; METABOTROPIC RECEPTOR ANTAGONIST; RETINA S ANTIGEN; UNCLASSIFIED DRUG; 7 (HYDROXYIMINO)CYCLOPROPAN(B)CHROMEN 1A CARBXOYLIC ACID ETHYL ESTER; 7-(HYDROXYIMINO)CYCLOPROPAN(B)CHROMEN-1A-CARBXOYLIC ACID ETHYL ESTER; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; BAY36 7620; BAY36-7620; BENZOIC ACID DERIVATIVE; CHROMONE DERIVATIVE; CLATHRIN; DRUG DERIVATIVE; GLYCINE; ISOPROTEIN; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR; NAPHTHALENE DERIVATIVE;

AGONIST; ARTICLE; CELL INCLUSION; CELL SURFACE; DRUG EFFECT; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR INTRINSIC ACTIVITY; ANIMAL; CELL LINE; CELL MEMBRANE; CYTOLOGY; DOSE RESPONSE; GENETICS; KIDNEY; METABOLISM; PROTEIN TRANSPORT; RAT;

ANIMALS; ARRESTIN; BENZOATES; CELL LINE; CELL MEMBRANE; CHROMONES; CLATHRIN; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; HUMANS; INOSITOL PHOSPHATES; KIDNEY; NAPHTHALENES; PROTEIN ISOFORMS; PROTEIN TRANSPORT; RATS; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 2542465774     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02387.x     Document Type: Article

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