Mechanism of suppression of cardiac L-type Ca2+ currents by the phospholipase A2 inhibitor mepacrine

European Journal of Pharmacology

Volumn 399, Issue 2-3, 2000, Pages 107-116

  Xiao, Yong Fu ^a   Zeind, Adib J ^a   Kaushik, Vinit ^a   Perreault Micale, Cynthia L ^a   Morgan, James P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Arachidonic acid; Ca2+ channel; Cardiomyocyte; Mepacrine; Phospholipase A2

Indexed keywords

ARACHIDONIC ACID; CALCIUM CHANNEL; CYCLIC AMP; MEPACRINE; PHOSPHOLIPASE A2;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART VENTRICLE WALL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENZYME INHIBITORS; HEART VENTRICLES; MALE; MEMBRANE POTENTIALS; PHOSPHOLIPASES A; QUINACRINE; RATS; RATS, WISTAR; TIME FACTORS;

EID: 0034617342     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00366-6     Document Type: Article

References (37)

1. Armstrong S.C., Ganote C.E. Effects of the phospholipase inhibitor mepacrine on injury in ischemic and metabolically inhibited adult isolated myocytes. Am. J. Pathol. 138:1991;545-555.
2. Barrigon S., Wang S.Y., Ji X., Langer G.A. Characterization of the calcium overload in cultured neonatal rat cardiomyocytes under metabolic inhibition. J. Mol. Cell. Cardiol. 28:1990;1329-1337.
3. Beasley D., Mcgulggin M.E. Interleukin 1 induces prostacyclin-dependent increases in cyclic AMP production and does not affect cyclic GMP production in human vascular smooth muscle cells. Cytokine. 7:1995;417-426.
4. 2. Basic Res. Cardiol. 92:1997;17-24.
5. Creer M.H., Dobmeyer D.J., Corr P.B. Amphipathic lipid metabolites and arrhythmias during myocardial ischemia. Zipes D.P., Jalife J. Cardiac Electrophysiology from Cell to Bedside. 1990;417-433 WB Saunders, Philadelphia, PA.
6. Chiariello M., Ambrosio G., Cappelli-Bigazzi M., Nevola E., Perrone-Filardi P., Marone G., Condorelli M. Inhibition of ischemia-induced phospholipase activation by quinacrine protects jeopardized myocardium in rats with coronary artery occlusion. J. Pharmacol. Exp. Ther. 241:1987;560-568.
7. Chiariello M., Ambrosio G., Cappelli-BigazziI M., Perrone-FilardiI P., Tritto I., Nevola E., Golino P. Reduction in infarct size by the phospholipase inhibitor quinacrine in dogs with coronary artery occlusion. Am. Heart J. 120:1990;801-807.
8. Chien K.R., Han A., Sen A., Buja L.M., Willerson J.T. Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids. Circ. Res. 54:1984;313-322.
9. 2+ cycling in cardiac myocytes by arachidonic acid. Circ. Res. 72:1993;376-386.
10. Das D.K., Eengelman R.M., Rousou J.A., Breyer R.H., Otani H., Lemeshow S. Role of membrane phospholipids in myocardial injury induced by ischemia and reperfusion. Am. J. Physiol. 251:1986;H71-H79.
11. 2+ exchange activity by quinacrine. Am. J. Physiol. 252:1987;C24-C29.
12. Exton J.H. Messenger molecules derived from membrane lipids. Curr. Opin. Cell Biol. 6:1994;226-229.
13. 2 inhibitors, mepacrine and chloroquine. Gen. Physiol. Biophys. 8:1989;113-118.
14. Karmazyn M. Synthesis and relevance of cardiac eicosanoids with particular emphasis on ischemia and reperfusion. Can. J. Physiol. Pharmacol. 67:1989;912-921.
15. Kloner R.A., Braunwald E. Effects of calcium antagonists on infarcting myocardium. Am. J. Cardiol. 59:1987;84B-94B.
16. Lee K.S., Tsien R.W. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature. 302:1983;790-794.
17. Mcdonald T.F., Pelzer S., Trautwein W., Pelzer D.J. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth cells. Physiol. Rev. 74:1994;365-507.
18. Moffat M.P., Ward C.A., Bend J.R. Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. Am. J. Physiol. 264:1993;H1154-H1160.
19. 2+ current by quinacrine in smooth muscle cells of the guinea pig. Jpn. J. Pharmacol. 71:1996;51-60.
20. Nishida M., Borzak S., Kraemer B., Navas J.P., Kelly R.A., Smith T.W., Marsh J.D. Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion. Am. J. Physiol. 264:1993;H1896-H1906.
21. Atani H., Engelman R.M., Breyer R.H., Rousou J.A., Lemeshow S., Das D.K. Mepacrine, a phospholipase inhibitor. A potential tool for modifying myocardial reperfusion injury. J. Thorac. Cardiovasc. Surg. 92:1986;247-254.
22. Post J.A., Clague J.R., Langer G.A. Sarcolemmal phospholipid asymmetry and Ca fluxes on metabolic inhibition of neonatal rat heart cells. Am. J. Physiol. 265:1993;H461-H468.
23. 2 and sarcolemmal phospholipids. Am. J. Physiol. 274:1998;H18-H26.
24. Rana R.S., Hokin L.E. Role of phosphoinositides in transmembrane signaling. Physiol. Rev. 70:1990;115-164.
25. 2. Eur. J. Biochem. 231:1995;593-601.
26. + exchange activity in purified canine cardiac sarcolemmal vesicles. J. Biol. Chem. 260:1985;4869-4876.
27. Sharp J.D., White D.L. Cytosolic PLA2: mRNA levels and potential for transcriptional regulation. J. Lipid Mediators. 8:1993;183-189.
28. 2. J. Biol. Chem. 266:1991;14850-14853.
29. Silverman H.S., Stern M.D. Ionic basis of ischaemic cardiac injury: insights from cellular studies. Cardiovasc. Res. 28:1994;581-597.
30. Uehara A., Hume J.R. Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J. Gen. Physiol. 85:1985;621-647.
31. 2-dependent signaling in the heart. Cardiovasc. Res. 30:1995;518-529.
32. Van Bilsen M., Van Der Vusse G.J., Willemsen P.H., Coumans W.A., Roemen T.H., Reneman R.S. Effects of nicotinic acid and mepacrine on fatty acid accumulation and myocardial damage during ischemia and reperfusion. J. Mol. Cell. Cardiol. 22:1990;155-163.
33. Van Der Vusse G.J., Glatz J.F., Stam H.C., Reneman R.S. Fatty acid homeostasis in the normoxic and ischemic heart. Physiol. Rev. 72:1992;881-940.
34. 2. Biochem. Pharmacol. 29:1979;623-627.
35. + channels mediate postcardioplegia coronary hyperemia. J. Thorac. Cardiovasc. Surg. 110:1995;1073-1082.
36. Xiao Y.-F., Mcardle J.J. Elevated density and altered pharmacologic properties of myocardial calcium current of the spontaneously hypertensive rat. J. Hypertens. 12:1994;783-790.
37. 2+ channels and contraction in mammalian heart cells. J. Physiol. (London). 508:1998;777-792.