Multiple signal transduction pathways mediated by 5-HT receptors

Molecular Neurobiology

Volumn 29, Issue 1, 2004, Pages 31-39

  Noda, Mami ^a   Higashida, Haruhiro ^b   Aoki, Shunsuke ^c   Wada, Keiji ^c  

^a KYUSHU UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

5 HT5A receptors; Adenylyl cyclase; ADP ribosyl cyclase; Cyclic ADP ribose; Cyclic AMP; Gi Go; IP3; K+ channels

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; ADENYLATE CYCLASE; CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HEPARIN; INOSITOL 1,4,5 TRISPHOSPHATE; PERTUSSIS TOXIN; PHOSPHOLIPASE C; POTASSIUM CHANNEL; SEROTONIN 5A RECEPTOR; CALCIUM; SEROTONIN RECEPTOR;

BRAIN DYSFUNCTION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; ENZYME INHIBITION; GLIOMA CELL; HUMAN; LONG TERM DEPRESSION; MENTAL DISEASE; NONHUMAN; POTASSIUM CURRENT; REVIEW; SECOND MESSENGER; SEROTONINERGIC SYSTEM; SEROTONINERGIC TRANSMISSION; SIGNAL TRANSDUCTION; ANIMAL; METABOLISM; PHYSIOLOGY;

ADENYLATE CYCLASE; ADP-RIBOSYL CYCLASE; ANIMALS; CALCIUM; CYCLIC AMP; GTP-BINDING PROTEINS; HUMANS; POTASSIUM CHANNELS; RECEPTORS, SEROTONIN; SIGNAL TRANSDUCTION;

EID: 2542426626     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1385/MN:29:1:31     Document Type: Review

References (44)

1. Barnes N. M. and Sharp T. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38, 1083-1152.
2. Albert P. R. and Tiberi M. (2001) Receptor signaling and structure: insights from serotonin-1 receptors. Trends Endocrinol. Metab. 12, 453-460.
3. Noda M., Yasuda S., Okada M., et al. (2003) Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways. J. Neurochem. 84, 222-232.
4. 1D receptor family. EMBO J. 11, 4779-4786.
5. Matthes H., Boschert U., Amlaiky N., et al. (1993) Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol. Pharmacol. 43, 313-319.
6. Erlander M. G., Lovenberg T. W., Baron B. M., et al. (1993) Two members of a distinct subfamily of 6-hydroxytryptamine receptors differentially expressed in rat brain. Pro. Natl. Acad. Sci. USA 90, 3452-3456.
7. 5B receptor couples to a G protein in mammalian cell membranes. FEBS Lett. 333, 25-31.
8. 5A serotonin receptor. FEBS Lett. 355, 242-246.
9. 5A receptor gene: systematic screening for DNA sequence variation and linkage mapping on chromosome 7q34-q36 using a polymorphism in the 5′ untranslated region. Biochem Biophys. Res. Commun. 233, 6-9.
10. 5B receptor was lost during mammalian evolution. Eur. J. Pharmacol. 418, 157-167.
11. 5A serotonin receptor in the methylotrophic yeast Pichia pastoris: pharmacological characterization and localization. FEBS Lett. 377, 451-456.
12. Humphrey P. P. A. (1997) The characterization and classification of neurotransmitter receptors. Ann. NY Acad. Sci. 812, 1-13.
13. 5A serotonin receptor mRNA in the human brain. Mol. Brain Res. 56, 1-8.
14. 5A serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: A mechanism for neuronal suppression of reactive astrocytes. GLIA 17, 317-326.
15. 7 receptors, in Handbook of Experimental Pharmacology. Serotonergic Neurons and 5-HT Receptors in the CNS, Baumgarten H. G. and Güthert M., eds., Springer-Verlag, Berlin pp. 475-497.
16. 5A receptors in the carotid body chemoreception pathway of rat. Neurosci Lett. 278, 9-12.
17. Grailhe R., Waeber C., Dulawa S. C., Hornung J. P., Zhuang X., Brunner D., Geyer M. A., and Hen R. (1999) Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Neuron 22, 581-591.
18. Iwata N., Ozaki N., Inada T., and Goldman D. (2001) Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia. Mol. Psychiatry 6, 217-219.
19. 5A gene in depression, psychosis and antipsychotic response. NeuroReport 11, 2017-2020.
20. 5A receptor gene in patients with bipolar disorder and major depression. Neurosci. Lett. 303, 111-114.
21. Kinsey A. M., Wainwright A., Heavens R., Sirinathsinghji D. J., and Oliver K. R. (2001) Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mRNAs in the rat brain. Brain Res. Mol. Brain Res. 88, 194-198.
22. Oliver K. R., Kinsey A. M., Wainwright A., and Sirinathsinghji D. J. (2000) Localization of 5-ht(5A) receptor-like immunoreactivity in the rat brain. Brain Res. 867, 131-142.
23. Duncan M. J., Jennes L., Jefferson J. B., and Brownfield M. S. (2000) Localization of serotonin(5A) receptors in discrete regions of the circadian timing system in the Syrian hamster. Brain Res. 869, 178-185.
24. Marazziti D., Ori M., Nardini M., Rossi A., Nardi I., and Cassano G. B. (2001) mRNA expression of serotonin receptors of type 2C and 5A in human resting lymphocytes. Neuropsychobiology 43, 123-126.
25. Hurley P. T., McMahon R. A., Fanning P., O'Boyle K. M., Rogers M., and Martin F. (1998) Functional coupling of a recombinant human 5-HT5a receptor to G-proteins in HEK-293 cells. Br. J. Pharmacol. 124, 1238-1244.
26. o proteins and inhibits adenylate cyclase in HEK293 cells. Eur. J. Pharmacol. 361, 299-309.
27. 5A receptor-mediated inhibition of cyclic AMP Accumulation in rat C6 glioma cells. J. Neurosci. Res. 61, 75-81.
28. 2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science 253, 1143-1146.
29. Lee H. C., Aarhus R., and Walseth T. F. (1993) Calcium mobilization by dual receptors during fertilization of sea urchin eggs. Science 261, 352-355.
30. 2+ channel. Nature 364, 76-79.
31. Higashida H., Hashii M., Yokoyama S., Hoshi N., Chen X. L., Egorova A., Noda M., and Zhang J. S. (2001) Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase. Pharmacol. Ther. 90, 283-296.
32. Morita K., Kitayama S., and Dohi T. (1997) Stimulation of cyclic ADP-ribose synthesis by acetylcholine and its role in catecholamine release in bovine adrenal chromaffin cells. J. Biol. Chem. 272, 21,002-21,009.
33. Mothet J. P., Fossier P., Meunier F. M., Stinnakre J., Tauc L., and Baux G. (1998) Cyclic ADP-ribose and calcium-induced calcium release regulate neurotransmitter release at a cholinergic synapse of Aplysia. J. Physiol. 507, 405-414.
34. Brailoiu E. and Miyamoto M. D. (2000) Inositol trisphosphate and cyclic adenosine diphosphate-ribose increase quantal transmitter release at frog motor nerve terminals: possible involvement of smooth endoplasmic reticulum. Neuroscience 95, 927-931.
35. Kato I., Takasawa S., Akabane A., et al. (1995) Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhancedinsulin secretion in CD38-expressing transgenic mice. J. Biol. Chem. 270, 30,045-30,050.
36. Reyes-Harde M., Empson R., Potter B. V., Galione A., and Stanton P. K. (1999a) Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus. Proc. Natl. Acad. Sci USA 96, 4061-4066.
37. 2+ release from cyclic ADP-ribose-sensitive stores. J. Neurophysiol. 82, 1569-1576.
38. White T. A., Walseth T. F., and Kannan M. S. (2002) Nitric oxide inhibits ADP-ribosyl cyclase through a cGMP-independent pathway in airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 283, L1065-1071.
39. Zocchi E., Carpaneto A., Cerrano C., et al. (2001) The temperature-signaling cascade in sponges involves a heat-gated cation channel, abscisic acid, and cyclic ADP-ribose. Proc. Natl. Acad. Sci USA 98, 14,859-14,864.
40. Ehrlich B. E., Kaftan E., Bezprozvannaya S., and Bezprozvanny I. (1994) The pharmacology of intracellular Ca(2+)-release channels. Trends Pharmacol. Sci. 15, 145-149.
41. 2+-dependent K+ channels in transformed NL308 neuroblastoma x fibroblast hybrid cells. Proc. R. Soc. Lond. B. 251, 215-224.
42. 2+ concentrations in neuroblastoma x fibroblast hybrid NL308 cells expressing m2 and m4 muscarinic acetylcholine receptor subtypes. Pflügers Arch. Eur. J. Physiol. 429, 426-433.
43. Mann J. J. (2003) Neurobiology of suicidal behaviour. Nat. Rev. Neurosci. 4, 819-828.
44. Muller C. P., Carey R. J., Huston J. P. (2003) Serotonin as an important mediator of cocaine's behavioral effects. Drugs Today (Barc) 39, 497-511.