The 5-HT(5A) serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: A mechanism for neuronal suppression of reactive astrocytes

GLIA

Volumn 17, Issue 4, 1996, Pages 317-326

  Carson, Monica J ^a   Thomas, Elizabeth A ^a   Danielson, Patria E ^a   Sutcliffe, J Gregor ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Gliosis; Second messengers

Indexed keywords

CYCLIC AMP; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; SEROTONIN RECEPTOR;

AGING; ANIMAL; ARTICLE; ASTROCYTE; DRUG ANTAGONISM; GENETICS; METABOLISM; MOUSE; NERVE CELL; NEWBORN; PHYSIOLOGY; RAT;

AGING; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CYCLIC AMP; GLIAL FIBRILLARY ACIDIC PROTEIN; MICE; NEURONS; RATS; RECEPTORS, SEROTONIN; RNA, MESSENGER;

EID: 0029658014     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199608)17:4<317::AID-GLIA6>3.0.CO;2-W     Document Type: Article

References (30)

1. Aviv, H. and Leder, P. (1972) Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid cellulose. Proc. Natl. Acad. Sci. USA, 69:1408-1412.
2. ID receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatriptan in the central nervous system of seven species. Eur. J. Pharmacol., 213:193-197.
3. Boess, F.G. and Martin, I.L. (1994) Molecular biology of 5-HT receptors. Neuropharmacology, 33:275-317.
4. 1. J. Pharmacol. Exp. Ther. 2673:1140-1146.
5. Cowen, P.J. (1991) Serotonin receptor subtypes: Implications for psychopharmacology. Br. J. Psychiatry, 12:7-14.
6. 1A receptor binding sites in some areas of the rat CNS during postnatal development. Int. J. Dev. Neurosci., 5:171-189.
7. 2+ responses in rat primary astrocyte cultures. J. Neurosci. Res., 35:246-256.
8. Erlander, M.G., Lovenberg, T.W., Baron, B.M., deLecea, L., Danielson, P.E., Racke, M., Slone, A.L., Siegel, B.W., Foye, P.E., Cannon, K., Burns, J.E., and Sutcliffe, J.G. (1993) Two members of a distinct subfamily of 4-hydroxytryptamine receptors differentially expressed in rat brain. Proc. Natl. Acad. Sci. USA, 90:3452-3456.
9. Feinberg, A.P. and Vogelstein, B. (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Analyt. Biochem., 132:6-13.
10. Frankfurt, M., O'Callaghan, J., and Beaudet, A. (1991) 5,7-Dihydrotryptamine injection increases glial fibrillary acidic protein in the hypothalamus of adult rats. Brain Res., 549:138-140.
11. Green, N., Alexander, H., Olson, A., Alexander, S., Schinnick, T.M., Sutcliffe, J.G., and Lerner, R.A. (1982) Immunogenic structure of the influenza virus hemagglutinin. Cell, 28:263-269.
12. Griffin, W.S.T. and Stanley, L.C. (1993) Glial activation as a common denominator in neurodegenerative disease: A hypothesis in neuropathophysiology. In: Biology and Pathology of Astrocyte-Neuron Interactions. Fedoroff et al., eds. Plenum Press, New York, pp. 359-381.
13. Hertz, L. (1991) Neuronal-astrocytic interactions in brain development, brain function and brain disease. Adv. Exp. Med. Biol., 296:143-159.
14. Hertz, L., Baldwin, F., and Schousboe, A. (1979) Serotonin receptors on astrocytes in primary culture: Effects of methysergide and fluoxetine. Can. J. Physiol. Pharmacol., 57:223-226.
15. 1A receptor mRNA and protein in rat embryonic brain stem cultures. Dev. Brain Res., 79:195-202.
16. 3H]5-hydroxytryptamine from fetal and maternal brain by drugs of abuse. Dev. Brain Res., 78:142-146.
17. LePrince, G., Copin, M.C., Hardin, H., Belin, M.F., Bouilloux, J.P., and Tardy, M. (1990) Neuron-glia interactions: Effect of serotonin on the astroglial expression of GFAP and its encoding message. Dev. Brain Res., 51:295-298.
18. Lucas, J.J. and Hen, R. (1995) New players in the 5-HT receptor field: Genes and knockouts. TIPS, 16:246-252.
19. 1 receptors and behavior. Neurosci. Biobehav. Rev., 16:83-93.
20. Martin, G.R. and and Humphrey, P.P.A. (1994) Receptors for 5-hydroxytryptamine: Current perspectives on classification and nomenclature. Neuropharmacology, 33:261-273.
21. 5B receptors define a new family of serotonin receptors: Cloning, functional expression, and chromosomal localization. Mol. Pharmacol., 43:313-319.
22. 1A receptors on the cerebellum of normal and X-irridiated rats during postnatal development. Neuroscience, 51:475-485.
23. 3 receptor agents. Pharmacol. Rev., 43:579-586.
24. Plassat, J.L., Boschert, U., Amlaiky, N., and Hen, R. (1992) The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. EMBO J. 11:4779-4786,
25. Raible, D.W. and McMorris, F.A. (1990) Induction of oligodendrocyte differentiation by activators of adenylate cyclase. J. Neurosci. Res., 27:43-46.
26. Schibler, K., Tosi, M., Pittet, A.C., Fabiani, L., and Wellauer, P.K. (1980) Tissue-specific expression of mouse α-amylase genes. J. Mol. Biol., 142:93-116.
27. Thomas, P.S. (1980) Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA, 77:5201-5205.
28. 2 muscarinic receptor in smooth muscle of guinea pig ileum. Mol. Neuropharmacol., 44:102-110.
29. 1A receptors to astroglial cells in adult rats: Implications for neuronal-glial interactions and psychoactive drug mechanism of action. Synapse, 14:201-205.
30. 1a receptors and S-100β in development and plasticity. Perspect. Dev. Neurobiol., 2:233-238.