Human 5-HT5 receptors: The 5-HT5A receptor is functional but the 5-HT5B receptor was lost during mammalian evolution

European Journal of Pharmacology

Volumn 418, Issue 3, 2001, Pages 157-167

  Grailhe, Régis ^a,b   Grabtree, Gregg W ^a   Hen, René ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Institu Pasteur 25 R Dr R   (France)

Author keywords

(Human); 5 HT5A receptor; Evolution; G protein coupled receptor; Null

Indexed keywords

1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 CARBAMIDOTRYPTAMINE; CLOZAPINE; ERGOTAMINE; IODINE 125; LISURIDE; LYSERGIDE; MESSENGER RNA; METITEPINE; POTASSIUM CHANNEL; RITANSERIN; SEROTONIN; SEROTONIN 5A RECEPTOR; SEROTONIN 5B RECEPTOR; SUMATRIPTAN; TRITIUM; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; GENE LIBRARY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAMMAL; MOLECULAR EVOLUTION; MONKEY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; RODENT; SEQUENCE HOMOLOGY; STOP CODON; TISSUE DISTRIBUTION; XENOPUS;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING, COMPETITIVE; CELL LINE; COS CELLS; DNA; EVOLUTION, MOLECULAR; GENE EXPRESSION; GENES; HUMANS; MEMBRANES; MICE; MOLECULAR SEQUENCE DATA; PHYLOGENY; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035957719     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00933-5     Document Type: Article

References (26)

1. 5A serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: a mechanism for neuronal suppression of reactive astrocytes. Glia. 17:1996;317-326.
2. Danielson P.E., Watson J.B., Gerendasy D.D., Erlander M.G., Lovenberg T.W., de Lecea L., Sutcliffe J.G., Frankel W.N. Chromosomal mapping of mouse genes expressed selectively within the central nervous system. Genomics. 19:1994;454-461.
3. + channel: expression cloning and molecular properties. Proc. Natl. Acad. Sci. U. S. A. 90:1993;10235-10239.
4. De Lean A., Kilpatrick B.F., Caron M.G. Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists. Mol. Pharmacol. 22:1982;290-297.
5. Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E., Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K. Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. Proc. Natl. Acad. Sci. U. S. A. 90:1993;3452-5346.
6. 5A receptor couple to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells. Eur. J. Pharmacol. 361:1998;299-309.
7. 5A receptor. Neuron. 22:1999;581-591.
8. Green S., Issemann I., Sheer E. A versatile in vivo and in vitro eukaryotic expression vector for protein engineering. Nucleic Acids Res. 16:1988;369-373.
9. Heymann J.A.W., Subramaniam S. Expression, stability, and membrane integration of truncation mutants of bovine rhodopsin. Proc. Natl. Acad. Sci. U. S. A. 94:1997;4966-4971.
10. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol. Rev. 46:1994;157-203. [Review].
11. 5A receptor to G-proteins in HEK-293 cells. Br. J. Pharmacol. 1998;1238-1244.
12. Kozak M. An analysis of 5'noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:1987;8125-8148.
13. Krieg P.A., Melton D.A. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acids Res. 12:1984;7057-7070.
14. Lucas J.J., Hen R. New players in the 5-HT receptor field: genes and knockouts. Trends Pharmacol. Sci. 16:1995;246-252. [Review].
15. Matthes H., Boschert U., Amlaiky N., Grailhe R., Plassat J.L., Muscatelli F., Mattei M.G., Hen R. Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol. Pharmacol. 43:1993;313-319.
16. Miwa J., Ibanez-Tallon M., Ibanez-Tallon I., Sanchez R., Sali A., Heintz N. Lynx, an endogenous toxin-like modulator of nicotinic receptors in the mammalian CNS. Neuron. 23:1999;105-114.
17. Munson P., Rodbard D. Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107(1):1980;220-239.
18. Nothen M.M., Cichon S., Hemmer S., Hebebrand J., Remschmidt H., Lehmkuhl G., Poustka F., Schmidt M., Catalano M., Fimmers R. Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity. Hum. Mol. Genet. 3:1994;2207-2212.
19. Olde B., McCombie W.R. Molecular cloning and functional expression of a serotonin receptor from Caenorhabditis elegans. J. Mol. Neurosci. 8:1997;53-62.
20. 1D receptor family. EMBO J. 11:1992;4779-4782.
21. 5A serotonin receptor. FEBS Lett. 355:1994;242-246.
22. 5A serotonin receptor binding: a preliminary structure-activity investigation. Med. Chem. Res. 7:1998;207-218.
23. Venter J.C., DiPorzio U., Robinson D.A., Shreeve S.M., Lai J., Kerlavage A.R., Fravcek S.P.J., Lentes K.U., Fraser C.M. Evolution of neurotransmitter receptor systems. Prog. Neurobiol. 30:1988;105-168.
24. 5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation. Ann. N. Y. Acad. Sci. 861:1998;85-90.
25. 5B receptor. Evidence that the 5-HT5B receptor couples to a G protein in mammalian cell membranes. FEBS Lett. 333:1993;25-31.
26. Wu X., Wakamiya M., Vaishnav S., Geske R., Montgomery C., Jones P., Bradley A., Caskey C.T. Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 91:1994;742-746.