Lipase-mediated stereoselective hydrolysis of stampidine and other phosphoramidate derivatives of stavudine

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 12, 2004, Pages 3371-3381

  Venkatachalam, T K ^a   Samuel, P ^a   Li, G ^a   Qazi, S ^a   Mao, C ^a   Pendergrass, S ^a   Uckun, F M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

Anti HIV; Lipase; Modeling; Stampidine; Stereochemistry

Indexed keywords

5' (2',3' DIDEHYDRO 3' DEOXYTHYMIDINE) 4 BROMOPHENYL N BIS(2 CHLOROETHYL)PHOSPHORAMIDATE; 5' (2',3' DIDEHYDRO 3' DEOXYTHYMIDINE) 4 METHOXYPHENYL N BIS(2 CHLOROETHYL)PHOSPHORAMIDATE; 5' (2',3' DIDEHYDRO 3' DEOXYTHYMIDINE) 4 METHYLPHENYL N BIS(2 CHLOROETHYL)PHOSPHORAMIDATE; 5' (2',3' DIDEHYDRO 3' DEOXYTHYMIDINE)PHENYL N BIS(2 CHLOROETHYL)PHOSPHORAMIDATE; ALANINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBOXYLIC ACID; DRUG METABOLITE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHORUS; STAMPIDINE; STAVUDINE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; WATER;

ANTIVIRAL ACTIVITY; ARTICLE; CANDIDA ANTARCTICA; CORRELATION ANALYSIS; CYCLIZATION; DRUG HYDROLYSIS; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; STEREOCHEMISTRY; STEREOISOMERISM;

AMIDES; ANTIVIRAL AGENTS; CANDIDA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERASES; HYDROLYSIS; INHIBITORY CONCENTRATION 50; LIPASE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHORIC ACIDS; PROTEIN CONFORMATION; STAVUDINE; STEREOISOMERISM; THYMIDINE MONOPHOSPHATE;

CANDIDA; CANDIDA ANTARCTICA;

EID: 2542421891     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.068     Document Type: Article

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