Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA interference

Biochemical and Biophysical Research Communications

Volumn 336, Issue 3, 2005, Pages 820-830

  Cheng, Tsung Lin ^a   Chang, Wen Wei ^a   Su, Ih Jen ^b   Lai, Ming Derg ^a   Huang, Wenya ^a   Lei, Huan Yao ^a   Chang, Wen Tsan ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

HBsAg transgenic mouse; HBV surface antigen; Hepatitis B virus; Hydrodynamics based transfection; RNA interference; Short hairpin RNA

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; SHORT HAIRPIN RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DNA VECTOR; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA INTERFERENCE; SCREENING; TRANSGENIC MOUSE; VIRUS INHIBITION;

ANIMALS; CELL LINE, TUMOR; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

HEPATITIS B VIRUS; MUS MUSCULUS;

EID: 25144498095     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.08.173     Document Type: Article

References (60)

1. D.M. Dykxhoorn, C.D. Novina, and P.A. Sharp Killing the messenger: short RNAs that silence gene expression Nat. Rev. Mol. Cell Biol. 4 2003 457 467
2. A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811
3. M.K. Montgomery, S. Xu, and A. Fire RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans Proc. Natl. Acad. Sci. USA 95 1998 15502 15507
4. S.M. Elbashir, W. Lendeckel, and T. Tuschl RNA interference is mediated by 21- and 22-nucleotide RNAs Genes Dev. 15 2001 188 200
5. S.M. Elbashir, J. Martinez, A. Patkaniowska, W. Lendeckel, and T. Tuschl Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate EMBO J. 20 2001 6877 6888
6. P.D. Zamore, T. Tuschl, P.A. Sharp, and D.P. Bartel RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals Cell 101 2000 25 33
7. S.M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498
8. S.M. Elbashir, J. Harborth, K. Weber, and T. Tuschl Analysis of gene function in somatic mammalian cells using small interfering RNAs Methods 26 2002 199 213
9. T.R. Brummelkamp, R. Bernards, and R. Agami A system for stable expression of short interfering RNAs in mammalian cells Science 296 2002 550 553
10. N.S. Lee, T. Dohjima, G. Bauer, H. Li, M.J. Li, A. Ehsani, P. Salvaterra, and J. Rossi Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells Nat. Biotechnol. 20 2002 500 505
11. C.P. Paul, P.D. Good, I. Winer, and D.R. Engelke Effective expression of small interfering RNA in human cells Nat. Biotechnol. 20 2002 505 508
12. G. Sui, C. Soohoo, el. B. Affar, F. Gay, Y. Shi, W.C. Forrester, and Y. Shi A DNA vector-based RNAi technology to suppress gene expression in mammalian cells Proc. Natl. Acad. Sci. USA 99 2002 5515 5520
13. K. Ashrafi, F.Y. Chang, J.L. Watts, A.G. Fraser, R.S. Kamath, J. Ahringer, and G. Ruvkun Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes Nature 421 2003 268 272
14. R.S. Kamath, A.G. Fraser, Y. Dong, G. Poulin, R. Durbin, M. Gotta, A. Kanapin, N. Le Bot, S. Moreno, M. Sohrmann, D.P. Welchman, P. Zipperlen, and J. Ahringer Systematic functional analysis of the Caenorhabditis elegans genome using RNAi Nature 421 2003 231 237
15. T. Tuschl Functional genomics: RNA sets the standard Nature 421 2003 220 221
16. L. Gitlin, and R. Andino Nucleic acid-based immune system: the antiviral potential of mammalian RNA silencing J. Virol. 77 2003 7159 7165
17. D.J. Shuey, D.E. McCallus, and T. Giordano RNAi: gene-silencing in therapeutic intervention Drug Discov. Today 7 2002 1040 1046
18. L. Gitlin, S. Karelsky, and R. Andino Short interfering RNA confers intracellular antiviral immunity in human cells Nature 418 2002 430 434
19. J.M. Jacque, K. Triques, and M. Stevenson Modulation of HIV-1 replication by RNA interference Nature 418 2002 435 438
20. S.B. Kapadia, A. Brideau-Andersen, and F.V. Chisari Interference of hepatitis C virus RNA replication by short interfering RNAs Proc. Natl. Acad. Sci. USA 100 2003 2014 2018
21. J.A. Wilson, S. Jayasena, A. Khvorova, S. Sabatinos, I.G. Rodrigue-Gervais, S. Arya, F. Sarangi, M. Harris-Brandts, S. Beaulieu, and C.D. Richardson RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells Proc. Natl. Acad. Sci. USA 100 2003 2783 2788
22. Q. Ge, M.T. McManus, T. Nguyen, C.H. Shen, P.A. Sharp, H.N. Eisen, and J. Chen RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription Proc. Natl. Acad. Sci. USA 100 2003 2718 2723
23. N.J. Caplen, Z. Zheng, B. Falgout, and R.A. Morgan Inhibition of viral gene expression and replication in mosquito cells by dsRNA-triggered RNA interference Mol. Ther. 6 2002 243 251
24. Z.N. Adelman, I. Sanchez-Vargas, E.A. Travanty, J.O. Carlson, B.J. Beaty, C.D. Blair, and K.E. Olson RNA silencing of dengue virus type 2 replication in transformed C6/36 mosquito cells transcribing an inverted-repeat RNA derived from the virus genome J. Virol. 76 2002 12925 12933
25. A.P. McCaffrey, H. Nakai, K. Pandey, Z. Huang, F.H. Salazar, H. Xu, S.F. Wieland, P.L. Marion, and M.A. Kay Inhibition of hepatitis B virus in mice by RNA interference Nat. Biotechnol. 21 2003 639 644
26. A. Shlomai, and Y. Shaul Inhibition of hepatitis B virus expression and replication by RNA interference Hepatology 37 2003 764 770
27. D. Ganem, and H.E. Varmus The molecular biology of the hepatitis B viruses Annu. Rev. Biochem. 56 1987 651 693
28. J.Y. Lau, and T.L. Wright Molecular virology and pathogenesis of hepatitis B Lancet 342 1993 1335 1340
29. W.M. Lee Hepatitis B virus infection N. Engl. J. Med. 337 1997 1733 1745
30. J.R. Wands, and H.E. Blum Primary hepatocellular carcinoma N. Engl. J. Med. 325 1991 729 731
31. P. Arbuthnot, and M. Kew Hepatitis B virus and hepatocellular carcinoma Int. J. Exp. Pathol. 82 2001 77 100
32. H.I. Yang, S.N. Lu, Y.F. Liaw, S.L. You, C.A. Sun, L.Y. Wang, C.K. Hsiao, P.J. Chen, D.S. Chen, and C.J. Chen Taiwan Community-Based Cancer Screening Project Group, Hepatitis B e antigen and the risk of hepatocellular carcinoma N. Engl. J. Med. 347 2002 168 174
33. M. Rapicetta, C. Ferrari, and M. Levrero Viral determinants and host immune responses in the pathogenesis of HBV infection J. Med. Virol. 67 2002 454 457
34. V. Carreno, and J.A. Quiroga Treatment of chronic hepatitis B with alpha-interferon. Present and future J. Hepatol. 13 Suppl. 1 1991 S2
35. J.H. Hoofnagle, and A.M. di Bisceglie The treatment of chronic viral hepatitis N. Engl. J. Med. 336 1997 347 356
36. P. Karayiannis Hepatitis B virus: old, new and future approaches to antiviral treatment J. Antimicrob. Chemother. 51 2003 761 785
37. C.L. Lai, C.K. Ching, A.K. Tung, E. Li, J. Young, A. Hill, B.C. Wong, J. Dent, and P.C. Wu Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: a placebo-controlled trial Hepatology 25 1997 241 244
38. N.A. Terrault, and T.L. Wright Therapy for chronic hepatitis B infection Adv. Exp. Med. Biol. 394 1996 189 205
39. Y.F. Fan, C.C. Lu, Y.C. Chang, T.T. Chang, P.W. Lin, H.Y. Lei, and I.J. Su Identification of a pre-S2 mutant in hepatocytes expressing a novel marginal pattern of surface antigen in advanced diseases of chronic hepatitis B virus infection J. Gastroenterol. Hepatol. 15 2000 519 528
40. Y.F. Fan, C.C. Lu, W.C. Chen, W.J. Yao, H.C. Wang, T.T. Chang, H.Y. Lei, A.L. Shiau, and I.J. Su Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection Hepatology 33 2001 277 286
41. H.C. Wang, H.C. Wu, C.F. Chen, N. Fausto, H.Y. Lei, and I.J. Su Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress Am. J. Pathol. 163 2003 2441 2449
42. H.C. Wang, W.T. Chang, W.W. Chang, H.C. Wu, W. Huang, H.Y. Lei, M.D. Lai, N. Fausto, and I.J. Su Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes Hepatology 41 2005 761 770
43. H. Giladi, M. Ketzinel-Gilad, L. Rivkin, Y. Felig, O. Nussbaum, and E. Galun Small interfering RNA inhibits hepatitis B virus replication in mice Mol. Ther. 8 2003 769 776
44. S.L. Uprichard, B. Boyd, A. Althage, and F.V. Chisari Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs Proc. Natl. Acad. Sci. USA 102 2005 773 778
45. C.H. Yuh, Y.L. Chang, and L.P. Ting Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virus J. Virol. 66 1992 4073 4084
46. W.W. Chang, I.J. Su, M.D. Lai, W.T. Chang, W. Huang, and H.Y. Lei The role of inducible nitric oxide synthase in a murine acute hepatitis B virus (HBV) infection model induced by hydrodynamics-based in vivo transfection of HBV-DNA J. Hepatol. 39 2003 834 842
47. L.G. Guidotti, B. Matzke, H. Schaller, and F.V. Chisari High level hepatitis B virus replication in transgenic mice J. Virol. 69 1995 6158 6169
48. C.M. Chu, P. Karayiannis, M.J. Fowler, J. Monjardino, Y.F. Liaw, and H.C. Thomas Natural history of chronic hepatitis B virus infection in Taiwan: studies of hepatitis B virus DNA in serum Hepatology 5 1985 431 434
49. C.M. Chu, and Y.F. Liaw Natural history of chronic hepatitis B virus infection: an immunopathological study J. Gastroenterol. Hetatol. 12 1997 S218 S222
50. M.R. Brunetto, U.A. Rodriguez, and F. Bonino Hepatitis B virus mutants Intervirology 42 1999 69 80
51. C.M. Hunt, J.M. McGill, M.I. Allen, and L.D. Condreay Clinical relevance of hepatitis B viral mutations Hepatology 31 2000 1037 1044
52. S. Locarnini, J. McMillan, and A. Bartholomeusz The hepatitis B virus and common mutants Semin. Liver Dis. 23 2003 5 20
53. W.N. Chen, C.J. Oon, A.L. Leong, S. Koh, and S.W. Teng Expression of integrated hepatitis B virus X variants in human hepatocellular carcinomas and its significance Biochem. Biophys. Res. Commun. 276 2000 885 892
54. K. Koike Hepatitis B virus HBx gene and hepatocarcinogenesis Intervirology 38 1995 134 142
55. K. Matsubara, and T. Tokino Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis Mol. Biol. Med. 7 1990 243 260
56. T.S. Yen Hepadnaviral X protein: review of recent progress J. Biomed. Sci. 3 1996 20 30
57. Y.D. Yoo, H. Ueda, K. Park, K.C. Flanders, Y.I. Lee, G. Jay, and S.J. Kim Regulation of transforming growth factor-β 1 expression by the hepatitis B virus(HBV)X transactivator. Role in HBV pathogenesis J. Clin. Invest. 97 1996 388 395
58. H.A. Dunsford, S. Sell, and F.V. Chisari Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice Cancer Res. 50 1990 3400 3407
59. Y. Nakamoto, L.G. Guidotti, C.V. Kuhlen, P. Fowler, and F.V. Chisari Immune pathogenesis of hepatocellular carcinoma J. Exp. Med. 188 1998 341 350
60. I. Toshkov, F.V. Chisari, and P. Bannasch Hepatic preneoplasia in hepatitis B virus transgenic mice Hepatology 20 1994 1162 1172