VeloceGenomics: An accelerated in vivo drug discovery approach to rapidly predict the biologic, drug-like activity of compounds, proteins, or genes

Pharmaceutical Research

Volumn 22, Issue 10, 2005, Pages 1597-1613

  Papoian, Ruben ^a   Scherer, Andreas ^a   Saulnier, Muriel ^a   Staedtler, Frank ^a   Cordier, André ^a   Legay, Francois ^a   Maurer, Gerard ^a   Staeheli, Joerg ^a   Vonderscher, Jacky ^a   Chibout, Salah Dine ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

In vivo compound profiling; In vivo RNA expression profiling; Mechanism of action; Microarray; Pharmacogenomics

Indexed keywords

CYTOKINE; G PROTEIN COUPLED RECEPTOR; GLUCAGON; GROWTH HORMONE; INSULIN; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; LIPOPOLYSACCHARIDE; PASIREOTIDE; RNA; SOMATOMEDIN; SOMATOMEDIN C; SOMATOSTATIN DERIVATIVE; TRANSCRIPTOME; TUMOR NECROSIS FACTOR;

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CELL GROWTH; CONTROLLED STUDY; DATA ANALYSIS; DNA MICROARRAY; DRUG ACTIVITY; DRUG DETERMINATION; FEMALE; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE TECHNOLOGY; GENOMICS; HYPOTHESIS; IN VIVO STUDY; INFLAMMATION; MALE; MOLECULE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHARMACOGENOMICS; PREDICTION; PRIORITY JOURNAL; PROTEIN FAMILY; UNINDEXED SEQUENCE; VELOCEGENOMICS;

ANIMALS; DRUG DESIGN; FEMALE; GENE EXPRESSION; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; MACACA FASCICULARIS; MALE; PHARMACOGENETICS; PREDICTIVE VALUE OF TESTS; PROTEIN ARRAY ANALYSIS; PROTEINS; RNA, MESSENGER; SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 25144493129     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-6809-8     Document Type: Article

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