Zinc protection of HepG2 cells from sporidesmin toxicity does not require de novo gene transcription

Toxicology Letters

Volumn 159, Issue 2, 2005, Pages 164-172

  Duncan, Elizabeth J ^a   Thompson, Mary P ^a   Phua, Sin H ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Actinomycin D; Epidithiodioxopiperazine; Hepatotoxin; HepG2; Sporidesmin; Zinc

Indexed keywords

DACTINOMYCIN; SPORIDESMIN; ZINC; ZINC SULFATE;

ARTICLE; CANCER CELL CULTURE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; GENETIC TRANSCRIPTION; HEPATOMA CELL; HUMAN; HUMAN CELL; LC 50; PRIORITY JOURNAL; TIME;

CELL LINE, TUMOR; CELL SURVIVAL; DACTINOMYCIN; HUMANS; L-LACTATE DEHYDROGENASE; PROTECTIVE AGENTS; PROTEIN SYNTHESIS INHIBITORS; SPORIDESMINS; TRANSCRIPTION, GENETIC; ZINC;

FUNGI; LEPTOSPHAERULINA CHARTARUM;

EID: 25144444519     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.05.005     Document Type: Article

References (50)

1. L.G. Atherton, D. Brewer, and A. Tayor Pithomyces chartarum: a fungal parameter in the aetiology of some diseases of domestic animals I.F.H. Purchase Mycotoxins 1974 Elsevier Amsterdam 29 68
2. R.K. Blanchard, and R.J. Cousins Differential display of intestinal mRNAs regulated by dietary zinc Proc. Natl. Acad. Sci. U.S.A. 93 1996 6863 6868
3. R.K. Blanchard, J.B. Moore, C.L. Green, and R.J. Cousins Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency Proc. Natl. Acad. Sci. U.S.A. 98 2001 13507 13513
4. G. Bodey, B. Bueltmann, W. Duguid, D. Gibbs, H. Hanak, M. Hotchi, G. Mall, P. Martino, F. Meunier, S. Milliken, S. Naoe, M. Okudaira, D. Scevola, and J. van't Wout Fungal infections in cancer patients: an international autopsy survey Eur. J. Clin. Microbiol. Infect. Dis. 11 1992 99 109
5. C.L. Chai, and P. Waring Redox sensitive epidithiodioxopiperazines in biological mechanisms of toxicity Redox. Rep. 5 2000 257 264
6. R.G. Collin, E. Odriozola, and N.R. Towers Sporidesmin production by Pithomyces chartarum isolates from Australia, Brazil, New Zealand and Uruguay Mycol. Res. 102 1998 163 166
7. S.J. Cordiner, and T.W. Jordan Inhibition by sporidesmin of hepatocyte bile acid transport Biochem. J. 212 1983 197 204
8. R.J. Cousins Zinc E.E. Ziegler L.J. Filer Jr. Present knowledge in nutrition 1996 International Life Sciences Institute Washington, DC 293 306
9. R.J. Cousins, R.K. Blanchard, M.P. Popp, L. Liu, J. Cao, J.B. Moore, and C.L. Green A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells Proc. Natl. Acad. Sci. U.S.A. 100 2003 6952 6957
10. I.J. Cunningham, C.S.M. Hopkirk, and J.F. Filmer Photosensitivity diseases in New Zealand NZ J. Sci. Tech. 1942 1985A-1198A
11. J. Done, P.H. Mortimer, A. Taylor, and D.W. Russell The production of sporidesmin and sporidesmolides by Pithomyces chartarum J. Gen. Microbiol. 26 1961 207 222
12. N. Ganju, and A. Eastman Zinc inhibits Bax and Bak activation and cytochrome c release induced by chemical inducers of apoptosis but not by death-receptor-initiated pathways Cell Death Differ 10 2003 652 661
13. M. Hara, and M. Han Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans Proc. Natl. Acad. Sci. U.S.A. 92 1995 3333 3337
14. A.J. Harris, S.L. Dial, and D.A. Casciano Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells Mutat. Res. 549 2004 79 99
15. A.M. Hurne, C.L. Chai, and P. Waring Inactivation of rabbit muscle creatine kinase by reversible formation of an internal disulfide bond induced by the fungal toxin gliotoxin J. Biol. Chem. 275 2000 25202 25206
16. T.W. Jordan, and J.S. Pedersen Sporidesmin and gliotoxin induce cell detachment and perturb microfilament structure in cultured liver cells J. Cell. Sci. 85 1986 33 46
17. T. Kambe, Y. Yamaguchi-Iwai, R. Sasaki, and M. Nagao Overview of mammalian zinc transporters Cell Mol. Life Sci. 61 2004 49 68
18. B. Kindermann, F. Doring, M. Pfaffl, and H. Daniel Identification of genes responsive to intracellular zinc depletion in the human colon adenocarcinoma cell line HT-29 J. Nutr. 134 2004 57 62
19. B.B. Knowles, C.C. Howe, and D.P. Aden Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen Science 209 1980 497 499
20. J.C. Lambert, Z. Zhou, and Y.J. Kang Suppression of Fas-mediated signalling pathway is involved in zinc inhibition of ethanol-induced liver apoptosis Exp. Biol. Med. (Maywood) 228 2003 406 412
21. S.C. Lu, and H.Y. Huang Comparison of sulphur amino acid utilization for GSH synthesis between HepG2 cells and cultured rat hepatocytes Biochem. Pharmacol. 47 1994 859 869
22. J.B. Moore, R.K. Blanchard, W.T. McCormack, and R.J. Cousins cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes J. Nutr. 131 2001 3189 3196
23. C.A. Morris, N.R. Towers, W.D. Hohenboken, N. Maqbool, B.L. Smith, and S.H. Phua Inheritance of resistance to facial eczema: a review of research findings from sheep and cattle in New Zealand NZ Vet. J. 52 2004 205 215
24. P.H. Mortimer, and B.S. Collins The in vitro toxicity of the sporidesmins and related compounds to tissue-culture cells Res. Vet. Sci. 9 1968 136 142
25. P.H. Mortimer, and J.W. Ronaldson Fungal toxin induced photosensitisation R.F. Keeler A.T. Tu Handbook of Natural Toxins. 1983 Marcel Dekker New York 361 419
26. P.H. Mortimer, and A. Taylor The experimental intoxication of sheep with sporidesmin, a metabolic product of pithomyces chartarum Res. Vet. Sci. 3 1962 147
27. R. Munday Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. 1. Generation of superoxide radical by sporidesmin Chem. Biol. Interact. 41 1982 361 374
28. R. Munday Studies on the mechanism of toxicity of the mycotoxin sporidesmin. 2. Evidence for intracellular generation of superoxide radical from sporidesmin J. Appl. Toxicol. 4 1984 176 181
29. R. Munday Studies on the mechanism of toxicity of the mycotoxin sporidesmin. 3. Inhibition by metals of the generation of superoxide radical by sporidesmin J. Appl. Toxicol. 4 1984 182 186
30. R. Munday Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. V. Generation of hydroxyl radical by sporidesmin J. Appl. Toxicol. 7 1987 17 22
31. R. Munday, A.M. Thompson, E.A. Fowke, C. Wesselink, B.L. Smith, N.R. Towers, K.O. O'Donnell, R.M. McDonald, M. Stirnemann, and A.J. Ford A zinc-containing intraruminal device for facial eczema control in lambs NZ Vet. J. 45 1997 93 98
32. R. Munday, A.M. Thompson, B.L. Smith, N.R. Towers, K.O. O'Donnell, R.M. McDonald, and M. Stirnemann A zinc-containing intraruminal device for prevention of the sporidesmin-induced cholangiopathy of facial eczema in calves NZ Vet. J. 49 2001 29 33
33. T. O'Brien, G. Babcock, J. Cornelius, M. Dingeldein, G. Talaska, D. Warshawsky, and K. Mitchell A comparison of apoptosis and necrosis induced by hepatotoxins in HepG2 cells Toxicol. Appl. Pharmacol. 164 2000 280 290
34. H.L. Pahl, B. Krauss, K. Schulze-Osthoff, T. Decker, E.B. Traenckner, M. Vogt, C. Myers, T. Parks, P. Warring, A. Muhlbacher, A.P. Czernilofsky, and P.A. Baeuerle The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB J. Exp. Med. 183 1996 1829 1840
35. P.L. Rodriguez, and L. Carrasco Gliotoxin: inhibitor of poliovirus RNA synthesis that blocks the viral RNA polymerase 3Dpol J. Virol. 66 1972 1971 1976
36. M.S. Segal, and E. Beem Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity Am. J. Physiol. Cell. Physiol. 281 2001 1196 1204
37. B.L. Smith, P.P. Embling, N.R. Towers, D.E. Wright, and E. Payne The protective effect of zinc sulphate in experimental sporidesmin poisoning of sheep NZ Vet. J. 25 1977 124 127
38. R. Sormunen, S. Eskelinen, and V.P. Lehto Bile canaliculus formation in cultured HepG2 cells Lab. Invest. 68 1993 652 662
39. H.R. Stennicke, and G.S. Salvesen Biochemical characteristics of caspases-3, -6, -7, and -8 J. Biol. Chem. 272 1997 25719 25723
40. H. tom Dieck, F. Doring, H.P. Roth, and H. Daniel Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays J. Nutr. 133 2003 1004 1010
41. N.R. Towers, and B.L. Smith The protective effect of zinc sulphate in experimental sporidesmin intoxication of lactating dairy cows NZ Vet. J. 26 1978 199 202
42. N.R. Towers, and G.C. Stratton Serum gamma-glutamyltransferase as a measure of sporidesmin-induced liver damage in sheep NZ Vet. J. 26 1978 109 112
43. C. Urani, M. Doldi, S. Crippa, and M. Camatini Human-derived cell lines to study xenobiotic metabolism Chemosphere 37 1998 2785 2795
44. C. Urani, P. Melchioretto, F. Morazzoni, C. Canevali, and M. Camatini Copper and zinc uptake and hsp70 expression in HepG2 cells Toxicol. In Vitro 15 2001 497 502
45. 2+ salts Int. J. Immunopharmacol. 12 1990 445 457
46. P. Waring, A. Sjaarda, and Q.H. Lin Gliotoxin inactivates alcohol dehydrogenase by either covalent modification or free radical damage mediated by redox cycling Biochem. Pharmacol. 49 1995 1195 1201
47. 2+ in renal tubular cells following ATP depletion Am. J. Physiol. Renal Physiol. 287 2004 492 500
48. J.C. Woodcock, W. Henderson, C.O. Miles, and B.K. Nicholson Metal complexes of sporidesmin D and dimethylgliotoxin, investigated by electrospray ionisation mass spectrometry J. Inorg. Biochem. 84 2001 225 232
49. J.C. Woodcock, W. Henderson, and C.O. Miles Metal complexes of the mycotoxins sporidesmin A and gliotoxin, investigated by electrospray ionisation mass spectrometry J. Inorg. Biochem. 85 2001 187 199
50. X. Zhou, A. Zhao, G. Goping, and P. Hirszel Gliotoxin-induced cytotoxicity proceeds via apoptosis and is mediated by caspases and reactive oxygen species in LLC-PK1 cells Toxicol. Sci. 54 2000 194 202