Redox sensitive epidithiodioxopiperazines in biological mechanisms of toxicity

Redox Report

Volumn 5, Issue 5, 2000, Pages 257-264

  Chai, C L L ^a   Waring, P ^b  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b Australian National University   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; CALCIUM ION; COPPER; CREATINE KINASE; CYSTEINE; DISULFIDE; DITHIOL DERIVATIVE; EPIDITHIODIOXOPIPERAZINE DERIVATIVE; FARNESYL TRANS TRANSFERASE; FERRIC ION; GLIOTOXIN; GLUTATHIONE; HYDROXYL RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PIPERAZINEDIONE; PLASMID DNA; REACTIVE OXYGEN METABOLITE; RNA POLYMERASE; SPORIDESMIN; SULFUR; SUPEROXIDE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL DISEASE; APOPTOSIS; ASPERGILLUS FUMIGATUS; AUTOOXIDATION; BILE DUCT INJURY; CALCIUM TRANSPORT; CELL MEMBRANE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DISULFIDE BOND; DNA STRAND BREAKAGE; ECZEMA; ENZYME INHIBITION; HUMAN; LIVER INJURY; METABOLITE; MICROFILAMENT; MITOCHONDRION; MYCOSIS; NONHUMAN; OXIDATION REDUCTION REACTION; PENICILLIUM; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; TOXICITY;

EID: 0033652478     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1179/135100000101535799     Document Type: Review

References (60)

1. Natural polysulfides
2. Redox signaling and the emerging therapeutic potential of thiol antioxidants
3. The toxicology of sporidesmins and other epipoly-thiodioxopiperazines
4. Fungal epipolythiodioxopiperazine toxins have therapeutic potential and roles in disease
5. Gliotoxin and epipolythiodioxopiperazines
6. The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines
7. Gliotoxin E: A new biologically active epipolythiodioxopiperazine from Penicillium terlikowskii
8. The isolation and identification of a new metabolite related to gliotoxin from cultures of Aspergillus fumigatus
9. Effects of gliotoxin and other sulphur containing compounds on tumor cells in vitro, with observations on mechanisms of action of gliotoxin
10. The involvement of the disulphide group of sporidesmin in the action of the toxin on the swelling and respiration of liver mitochondria
11. Structural relationships of epipolythiodixoxpiperazines and their immunomodulating activity
12. Hyalodendrin: A new fungitoxic epidithiodioxopiperazine produced by a Hyalodendron species
13. Isolierung von 11α, 11'α-dihydroxychaetocinaus Verticillium tenenum
14. The structure of chetomin
15. Aranotin and related metabolites: II. Isolation, characterization and structures of two new metabolites
16. Verticillin A, a new antibiotic from Verticillium spp
17. Gliotoxin, the antibiotic principle of Gliocladium fimbriatum. Production, physical and biological properties
18. The incidence of subclinical facial eczema in selected Waikato dairy herds
19. Ambewelamides A and B, antineoplastic epidithiopiperazinediones isolated from the lichen Usnea spp
20. Structure revision and cytotoxic activity of the scabrosin esters, epidithiopiperazinediones from the lichen Xanthoparmelia scabrosa
21. Advances in veterinary mycology
22. Pathological, anatomical and mycotoxicological studies of aspergillosis in birds
23. In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi
24. Endogenous toxins and mycotoxins in forage grasses and their effects on livestock
25. Inhibition by sporidesmin of hepatocyte bile acid transport
26. Ras farnesyl transferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans
27. Gliotoxin inactivates alcohol dehydrogenase by either covalent modification or free radical damage mediated by redox cycling
28. Gliotoxin: Inhibitor of poliovirus RNA synthesis that blocks the viral RNA polymerase 3D(pol)
29. Gliotoxin inhibits creatine kinase by reversible formation of an internal disulphide bond
30. The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-κB
31. Studies on the mechanism of toxicity of the mycotoxin sporidesmin. Evidence for intracellular generation of superoxide radical from sporidesmin
32. Studies on the mechanism of toxicity of the mycotoxin sporidesmin. Generation of hydroxyl radicals by sporidesmin
33. Toxicity of thiols and disulphides; involvement of free radical species
34. Effect of antioxidants on the toxicity of the facial eczema toxin, sporidesmin, in sheep
35. Gliotoxin causes oxidative damage to plasmid and cellular DNA
36. Synthesis and activity of new epipolythiopiperazine-2,5-dione compounds
37. Cellular uptake and release of the immunomodulating fungal toxin gliotoxin
38. A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes
39. 2+ release from rat skeletal muscle mitochondria
40. The effect of gliotoxin upon macrophage function
41. Immunosuppression in vitro by a metabolite of a human pathogenic fungus
42. Gliotoxin induces apoptosis in macrophages unrelated to its antiphagocytic properties
43. Fungal toxin gliotoxin targets the onset of superoxide generating NADPH oxidase of human neutrophils
44. Gliotoxin induced cytotoxicity proceeds via apoptosis and is mediated by caspases and reactive oxygen species in LLC-PK1 cells
45. Lack of correlation between early intracellular cellular calcium ion rises and the onset of apoptosis in thymocytes
46. Intracellular calcium rises induced by ETP toxins resulting from interaction with plasma membrane thiol groups. In preparation
47. DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels
48. DNA synthesis precedes gliotoxin induced apoptosis
49. Apoptosis induced in macrophages and T blasts by the mycotoxin sporidesmin and protection by zinc salts
50. Phosphorylation of histone H3 precedes gliotoxin induced apoptosis in thymocytes
51. Evidence that gliotoxin enhances lymphocyte activation and induces apoptosis by effects on cyclic AMP levels
52. Thiol/disulfide exchange equilibria and disulfide bond stability
53. Activation parameters for thiolate-disulfide interchange reactions in aqueous solution
54. Rate constants and equilibrium constants for thiol-disulfide interchange reactions involving oxidized glutathione
55. The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α'-disulfide cyclic dipeptides
56. The structure of the methylene dibromide adduct of sporidesmin at - 150°C
57. The crystal structure of gliotoxin
58. Cyclo-L-cystine acetic acid
59. Oxidation of thiols
60. Sulfur-centred free radicals