Chronic oral treatment with 13-cis-retinoic acid (Isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats

Toxicological Sciences

Volumn 87, Issue 2, 2005, Pages 451-459

  Ferguson, Sherry A ^a   Cisneros, F Javier ^a   Gough, B ^a   Hanig, Joseph P ^b   Berry, Kimberly J ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

13 cis retinoic acid; All trans retinoic acid; Anhedonia; Depression; Forced Swim Test; Isotretinoin; Locomotor activity

Indexed keywords

ISOTRETINOIN; RETINOIC ACID; SACCHARIN;

ANHEDONIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG BLOOD LEVEL; FEMALE; MALE; MAZE TEST; NONHUMAN; OPEN FIELD BEHAVIOR; PERINATAL PERIOD; PHYSICAL ACTIVITY; QUALITATIVE ANALYSIS; RAT; SEX DIFFERENCE; SWIMMING;

AGING; ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; DEPRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; EATING; FEMALE; ISOTRETINOIN; KERATOLYTIC AGENTS; MALE; MOTOR ACTIVITY; RATS; SACCHARIN; SEX CHARACTERISTICS; SWEETENING AGENTS; SWIMMING; TRETINOIN;

ANIMALIA;

EID: 24944558127     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi262     Document Type: Article

References (72)

1. Abel, E. L. (1991). Gradient of alarm substance in the Forced Swimming Test. Physiol. Behav. 49, 321-323.
2. Abel, E. L. (1992). Response to alarm substance in different rat strains. Physiol. Behav. 51, 345-347.
3. Alonso, S. J., Castellano, M. A., Afonso, D., and Rodriguez, M. (1991). Sex differences in behavioral despair: Relationships between behavioral despair and open field activity. Physiol. Behav. 49, 69-72.
4. Angst, J. (1998). Treated versus untreated major depressive episodes. Psychopathology 31, 37-44.
5. Anisman, H., and Matheson, K. (2005). Stress, depression, and anhedonia: Caveats concerning animal models. Neurosci. Biobehav. Rev. 29, 525-546.
6. Asano, Y. (1986). Characteristics of open field behavior of Wistar and Sprague-Dawley rats. Jikken Dobutsu 35, 505-508.
7. Ayensu, W. K., Pucilowski, O., Mason, G. A., Overstreet, D. H., Rezvani, A. H., and Janowsky, D. S. (1995). Effects of chronic mild stress on serum complement activity, saccharin preference, and corticosterone levels in Flinders lines of rats. Physiol. Behav. 57, 165-169.
8. Barros, H. M., and Ferigolo, M. (1998). Ethopharmacology of imipramine in the forced-swimming test: Gender differences. Neurosci. Biobehav. Rev. 23, 279-286.
9. Blazer, D. G., Kessler, R. C., McGonagle, K. A., and Swartz, M. S. (1994). The prevalence and distribution of major depression in a national community sample: The National Comorbidity Survey. Am. J. Psychiatry 151, 979-986.
10. Borsini, F., and Meli, A. (1988). Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology (Berl.) 94, 147-160.
11. Brotto, L. A., Barr, A. M., and Gorzalka, B. B. (2000). Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin. Eur. J. Pharmacol. 402, 87-93.
12. Bruner, C. A., and Vargas, I. (1994). The activity of rats in a swimming situation as a function of water temperature. Physiol. Behav. 55, 21-28.
13. Byrne, A., Costello, M., Greene, E., and Zibin, T. (1998). Isotretinoin therapy and depression - Evidence for an association. Irish J. Psychol. Med. 15, 58-60.
14. Byrne, A., and Hnatko, G. (1995). Depression associated with isotretinoin therapy. Can. J. Psychiatry 40, 567.
15. Crandall, J., Sakai, Y., Zhang, J., Koul, O., Mineur, Y., Crusio, W. E., and McCaffery, P. (2004). 13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice. Proc. Natl. Acad. Sci. U. S. A. 101, 5111-5116.
16. Crettaz, M., Baron, A., Siegenthaler, G., and Hunziker, W. (1990). Ligand specificities of recombinant retinoic acid receptors RAR alpha and RAR beta. Biochem. J. 272, 391-397.
17. Cryan, J. F., Valentino, R. J., and Lucki, I. (2005). Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci. Biobehav. Rev. 29, 547-569.
18. D'Aquila, P. S., Peana, A. T., Carboni, V., and Serra, G. (2000). Exploratory behaviour and grooming after repeated restraint and chronic mild stress: Effect of desipramine. Eur. J. Pharmacol. 399, 43-47.
19. Duncko, R., Kiss, A., Skultetyova, I., Rusnak, M., and Jezova, D. (2001). Corticotropin-releasing hormone mRNA levels in response to chronic mild stress rise in male but not in female rats while tyrosine hydroxylase mRNA levels decrease in both sexes. Psychoneuroendocrinology 26, 77-89.
20. Ellis, C. N., and Krach, K. J. (2001). Uses and complications of isotretinoin therapy. J. Am. Acad. Dermatol. 45, S150-S157.
21. Ernst, C., and Angst, J. (1992). The Zurich Study. XII. Sex differences in depression. Evidence from longitudinal epidemiological data. Eur. Arch. Psychiatry Clin. Neurosci. 241, 222-230.
22. Etchamendy, N., Enderlin, V., Marighetto, A., Vouimba, R. M., Pallet, V., Jaffard, R., and Higueret, P. (2001). Alleviation of a selective age-related memory deficit in mice by pharmacologically-induced normalization of the brain retinoid signalling. J. Neurosci. 21, 6423-6429.
23. Fennig, S., Schwartz, J. E., and Bromet, E. J. (1994). Are diagnostic criteria, time of episode and occupational impairment important determinants of the female:mAle ratio for major depression? J. Affect. Disord. 30, 147-154.
24. Ferahbas, A., Turan, M. T., Esel, E., Utas, S., Kutlugun, C., and Kilic, C. G. (2004). A pilot study evaluating anxiety and depressive scores in acne patients treated with isotretinoin. J. Dermatolog. Treat. 15, 153-157.
25. Ferguson, S. A., Flynn, K. M., Delclos, K. B., and Newbold, R. R. (2000). Maternal and offspring toxicity but few sexually dimorphic behavioral alterations result from nonylphenol exposure. Neurotoxicol. Teratol. 22, 583-591.
26. Fleischer, A. B., Jr., Simpson, J. K., McMichael, A., and Feldman, S. R. (2003). Are there racial and sex differences in the use of oral isotretinoin for acne management in the United States? J. Am. Acad. Dermatol. 49, 662-666.
27. Flynn, K. M., Delclos, K. B., Newbold, R. R., and Ferguson, S. A. (2001). Behavioral responses of rats exposed to long-term dietary vinclozolin. J. Agric. Food Chem. 49, 1658-1665.
28. Frazer, A., and Morilak, D. A. (2005). What should animal models of depression model? Neurosci. Biobehav. Rev. 29, 515-523.
29. Furchtgott, E., Wechkin, S., and Dees, J. W. (1961). Open-field exploration as a function of age. J. Comp. Physiol. Psychol. 54, 386-388.
30. Geiger, J. M., Hommel, L., Harms, M., and Saurat, J. H. (1996). Oral 13-cis retinoic acid is superior to 9-cis retinoic acid in sebosuppression in human beings. J. Am. Acad. Dermatol. 34, 513-515.
31. Goldsmith, L. A., Bolognia, J. L., Callen, J. P., Chen, S. C., Feldman, S. R., Lim, H. W., Lucky, A. W., Reed, B. R., Siegfried, E. C., Thiboutot, D. M., and Wheeland, R. G. (2004). American Academy of Dermatology Consensus Conference on the safe and optimal use of isotretinoin: Summary and recommendations. J. Am. Acad. Dermatol. 50, 900-906.
32. Hansen-Trench, L. S., and Barron, S. (2005). Effects of neonatal alcohol and/or cocaine exposure on stress in juvenile and adult female rats. Neurotoxicol. Teratol. 27, 55-63.
33. Hawkins, J., Hicks, R. A., Phillips, N., and Moore, J. D. (1978). Swimming rats and human depression. Nature 274, 512-513.
34. Hazen, P. G., Carney, J. F., Walker, A. E., and Stewart, J. J. (1983). Depression - A side effect of 13-cis-retinoic acid therapy. J. Am. Acad. Dermatol. 9, 278-279.
35. Hersom, K., Neary, M. P., Levaux, H. P., Klaskala, W., and Strauss, J. S. (2003). Isotretinoin and antidepressant pharmacotherapy: A prescription sequence symmetry analysis. J. Am. Acad. Dermatol. 49, 424-432.
36. Hotchkiss, C. E., Latendresse, J. R., and Ferguson, S. A. (2005). Oral treatment with 13-cis- and all-trans-retinoic acid in male and female adult rats. Bone In press.
37. Jacobs, D. G., Deutsch, N. L., and Brewer, M. (2001). Suicide, depression, and isotretinoin: Is there a causal link? J. Am. Acad. Dermatol. 45, S168-S175.
38. Jick, S. S., Kremers, H. M., and Vasilakis-Scaramozza, C. (2000). Isotretinoin use and risk of depression, psychotic symptoms, suicide, and attempted suicide. Arch. Dermatol. 136, 1231-1236.
39. Kempermann, G. (2002). Regulation of adult hippocampal neurogenesis - Implications for novel theories of major depression. Bipolar Disord. 4, 17-33.
40. Kim, Y. W., Sharma, R. P., and Li, J. K. (1994). Characterization of heterologously expressed recombinant retinoic acid receptors with natural or synthetic retinoids. J. Biochem. Toxicol. 9, 225-234.
41. Kopp, C., Vogel, E., Rettori, M. C., Delagrange, P., and Misslin, R. (1999). The effects of melatonin on the behavioral disturbances induced by chronic mild stress in C3H/He mice. Behav. Pharmacol. 10, 73-83.
42. Lucki, I. (1997). The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav. Pharmacol. 8, 523-532.
43. Malberg, J. E., Eisch, A. J., Nestler, E. J., and Duman, R. S. (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20, 9104-9110.
44. Malberg, J. E., and Schechter, L. E. (2005). Increasing hippocampal neurogenesis: A novel mechanism for antidepressant drugs. Curr. Pharm. Des. 11, 145-155.
45. Matthews, K., Christmas, D., Swan, J., and Sorrell, E. (2005). Animal models of depression: Navigating through the clinical fog. Neurosci. Biobehav. Rev. 29, 503-513.
46. McCance-Katz, E. F., and Price, L. H. (1992). Depression associated with vitamin A intoxication. Psychosomatics 33, 117-118.
47. Mitchell, P. J., and Redfern, P. H. (2005). Animal models of depressive illness: The importance of chronic drug treatment. Curr. Pharm. Des. 11, 171-203.
48. Nakamura, K., and Tanaka, Y. (2001). Antidepressant-like effects of aniracetam in aged rats and its mode of action. Psychopharmacology (Berl.) 158, 205-212.
49. Nestler, E. J., Gould, E., Manji, H., Buncan, M., Duman, R. S., Greshenfeld, H. K., Hen, R., Koester, S., Lederhendler, I., Meaney, M., et al. (2002). Preclinical models: Status of basic research in depression. Biol. Psychiatry 52, 503-528.
50. Ng, C. H., Tam, M. M., Celi, E., Tate, B., and Schweitzer, I. (2002). Prospective study of depressive symptoms and quality of life in acne vulgaris patients treated with isotretinoin compared to antibiotic and topical therapy. Australas. J. Dermatol. 45, 262-268.
51. Nielsen, C. K., Arnt, J., and Sanchez, C. (2000). Intracranial self-stimulation and sucrose intake differ as hedonic measures following chronic mild stress: Interstrain and interindividual differences. Behav. Brain Res. 107, 21-33.
52. Nishimura, H., Tsuda, A., Oguchi, M., Ida, Y., and Tanaka, M. (1988). Is immobility of rats in the forced swim test "behavioral despair"? Physiol. Behav. 42, 93-95.
53. O'Donnell, J. (2003). Overview of existing research and information linking isotretinoin (Accutane), depression, psychosis, and suicide. Am. J. Ther. 10, 148-159.
54. Overstreet, D. H., Pucilowski, O., Rezvani, A. H., and Janowsky, D. S. (1995). Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression. Psychopharmacology (Berl.) 121, 27-37.
55. Papp, M., Moryl, E., and Willner, P. (1996). Pharmacological validation of the chronic mild stress model of depression. Eur. J. Pharmacol. 296, 129-136.
56. Porsolt, R. D., Le Pichon, M., and Jalfre, M. (1977). Depression: A new animal model sensitive to antidepressant treatments. Nature 266, 730-732.
57. Pucilowski, O., Overstreet, D. H., Rezvani, A. H., and Janowsky, D. S. (1993). Chronic mild stress-induced anhedonia: Greater effect in a genetic rat model of depression. Physiol. Behav. 54, 1215-1220.
58. Rex, A., Schickert, R., and Fink, H. (2004). Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats. Pharmacol. Biochem. Behav. 77, 303-307.
59. Sakai, Y., Crandall, J. E., Brodsky, J., and McCaffery, P. (2004). 13- cis Retinoic acid (Accutane) suppresses hippocampal cell survival in mice. Ann. N. Y. Acad. Sci. 1021, 436-440.
60. Sanchez, C., and Meier, E. (1997). Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike? Psychopharmacology (Berl.) 129, 197-205.
61. Scheinman, P. L., Peck, G. L., Rubinow, D. R., DiGiovanna, J. J., Abangan, D. L., and Ravin, P. D. (1990). Acute depression from isotretinoin. J. Am. Acad. Dermatol. 22, 1112-1114.
62. Tannenbaum, B., Tannenbaum, G. S., Sudom, K., and Anisman, H. (2002). Neurochemical and behavioral alterations elicited by a chronic intermittent stressor regimen: Implications for allostatic load. Brain Res. 953, 82-92.
63. Thierry, B., Steru, L., Chermat, R., and Simon, P. (1984). Searching-waiting strategy: A candidate for an evolutionary model of depression? Behav. Neural. Biol. 41, 180-189.
64. Thompson, M. R., Li, K. M., Clemens, K. J., Gurtman, C. G., Hunt, G. E., Cornish, J. L., and McGregor, I. S. (2004). Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats. Neuropsychopharmacology 29, 694-704.
65. Vazquez-Palacios, G., Bonilla-Jaime, H., and Velazquez-Moctezuma, J. (2005). Antidepressant effects of nicotine and fluoxetine in an animal model of depression induced by neonatal treatment with clomipramine. Prog. Neuropsychopharmacol. Biol. Psychiatry 29, 39-46.
66. Weiss, J. M. (1968). Effects of coping responses on stress. J. Comp. Physiol. Psychol. 65, 251-260.
67. Willner, P. (1995). Animal models of depression: Validity and applications. In Depression and Mania: From Neurobiology to Treatment (G. Gessa, Fratta, W., Pani, L., Serra, G., Eds.), pp. 10-41. Raven Press, New York.
68. Willner, P. (1997). Validity, reliability and utility of the chronic mild stress model of depression: A 10-year review and evaluation. Psychopharmacology (Berl.) 134, 319-329.
69. Wooltorton, E. (2003). Accutane (isotretinoin) and psychiatric adverse effects. Can. Med. Assoc. J. 168, 66.
70. Wysowski, D. K., Pitts, M., and Beitz, J. (2001). An analysis of reports of depression and suicide in patients treated with isotretinoin. J. Am. Acad. Dermatol. 45, 515-519.
71. Yadid, G., Nakash, R., Deri, I., Tamar, G., Kinor, N., Gispan, I., and Zangen, A. (2000). Elucidation of the neurobiology of depression: Insights from a novel genetic animal model. Prog. Neurobiol. 62, 353-378.
72. Zacharko, R. M., Bowers, W. J., Kokkinidis, L., and Anisman, H. (1983). Region-specific reductions of intracranial self-stimulation after uncontrollable stress: Possible effects on reward processes. Behav. Brain Res. 9, 129-141.