Novel p38 MAP kinase inhibitor R-130823 suppresses IL-6, IL-8 and MMP-13 production in spheroid culture of human synovial sarcoma cell line SW 982

Immunology Letters

Volumn 101, Issue 1, 2005, Pages 50-59

  Wada, Yoshihiro ^a   Shimada, Kohei ^a   Kimura, Tomio ^a   Ushiyama, Shigeru ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Interleukin; Matrix metalloproteinase; p38 MAP kinase; Prostaglandin E2; Spheroid; Synoviocyte

Indexed keywords

10,11 DIHYDRO 3 [3 (2 PYRIDINYLAMINO)PROPOXY] 5H DIBENZO[A,D]CYCLOHEPTENE 10 ACETIC ACID; 10,11 DIHYDRO 3 [3 (PYRIDIN 2 YLAMINO) 1 PROPYLOXY] 5H DIBENZO[A,D] CYCLOHEPTANE 10 ACETIC ACID; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (4 FLUOROPHENYL) 4 (1 PHENETHYL 1,2,3,6 TETRAHYDROPYRIDIN 4 YL) 3 (PYRIDIN 4 YL) 1H PYRROLE; COLLAGENASE 3; GELATINASE A; INTEGRIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; OLIGOPEPTIDE; PROSTAGLANDIN E2; PROTEIN INHIBITOR; R 130823; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR INHIBITOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; INHIBITION KINETICS; MONOLAYER CULTURE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SPHEROID CELL; TRANSCRIPTION REGULATION;

CELL ADHESION; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DINOPROSTONE; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MATRIX METALLOPROTEINASE 13; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; PYRROLES; SARCOMA, SYNOVIAL; SPHEROIDS, CELLULAR;

EID: 24744465863     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2005.04.010     Document Type: Article

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