Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: Implications for analysis of thymus function

Journal of Clinical Immunology

Volumn 25, Issue 5, 2005, Pages 462-472

  Sempowski, Gregory D ^a   Hicks, Charles B ^a   Eron, Joseph J ^a   Bartlett, John A ^a   Hale, Laura P ^a   Ferrari, Guido ^a   Edwards, Lloyd J ^b   Fiscus, Susan ^b   Haynes, Barton F ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Acute HIV 1 infection; Na ve T cells; Thymus

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA; VIRUS RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALE; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; SYMPTOM; T LYMPHOCYTE; THYMUS FUNCTION;

ADULT; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOPHENOTYPING; MALE; RECEPTORS, INTERLEUKIN-2; STAINING AND LABELING; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TIME FACTORS; VIRAL LOAD;

EID: 24744449753     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-005-5635-4     Document Type: Article

References (33)

1. Dion ML, Poulin JF, Bordi R, Sylvestre M, Corsini R, Kettaf N, Dalloul A, Boulassel MR, Debre P, Routy JP, Grossman Z, Sekaly RP, Cheynier R: HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation. Immunity 21:757-768, 2004
2. Douek DC, Betts MR, Hill BJ, Little SJ, Lempicki R, Metcalf JA, Casazza J, Yoder C, Adelsberger JW, Stevens RA, Baseler MW, Keiser P, Richman DD, Davey RT, Koup RA: Evidence for increased T cell turnover and decreased thymic output in HIV infection. J Immunol 167:6663-6668, 2001
3. Douek DC, Picker LJ, Koup RA: T cell dynamics in HIV-1 infection. Ann Rev Immunol 21:265-304, 2003
4. Pilcher CD, Eron JJ, Jr, Galvin S, Gay C, Cohen MS: Acute HIV revisited: New opportunities for treatment and prevention. J Clin Invest 113:937-945, 2004
5. Pilcher CD, Price MA, Hoffman IF, Galvin S, Martinson FE, Kazembe PN, Eron JJ, Miller WC, Fiscus SA, Cohen MS: Frequent detection of acute primary HIV infection in men in Malawi. AIDS 18:517-524, 2004
6. Pilcher CD, Eron JJ, Jr, Vemazza PL, Battegay M, Harr T, Yerly S, Vom S, Perrin L: Sexual transmission during the incubation period of primary HIV infection. JAMA 286:1713-1714, 2001
7. Pilcher CD, McPherson JT, Leone PA, Smurzynski M, Owen-O'Dowd J, Peace-Brewer AL, Harris J, Hicks CB, Eron JJ, Jr, Fiscus SA: Real-time, universal screening for acute HIV infection in a routine HIV counseling and testing population. JAMA 288:216-221, 2002
8. Kollmann TR, Pettoello-Mantovani M, Zhuang X, Kim A, Hachamovitch M, Smarnworawong P, Rubinstein A, Goldstein H: Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1. J Exp Med 179:513-522, 1994
9. Goldstein H, Pettoello-Mantovani M, Katopodis NF, Kim A, Yurasov S, Kollmann TR: SCID-hu mice: A model for studying disseminated HIV infection. Semin Immunol 8:223-231, 1996
10. Kollmann TR, Kim A, Pettoello-Mantovani M, Hachamovitch M, Rubinstein A, Goldstein MM, Goldstein H: Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice. J Immunol 154:907-921, 1995
11. Pettoello-Mantovani M, Kollmann TR, Katopodis NF, Raker C, Kim A, Yurasov S, Wiltshire H, Goldstein H: thy/liv-SCID-hu mice: A system for investigating the in vivo effects of multidrug therapy on plasma viremia and human immunodeficiency virus replication in lymphoid tissues. J Infect Dis 177:337-346, 1998
12. Sopper S, Nierwetberg D, Halbach A, Sauer U, Scheller C, Stahl-Hennig C, Matz-Rensing K, Schafer F, Schneider T, ter Meulen V, Muller JG: Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers and T-cell turnover in different organs of rhesus monkeys. Blood 101:1213-1219, 2002
13. Reyes RA, Canfield DR, Esser U, Adamson LA, Brown CR, Cheng-Mayer C, Gardner MB, Harouse JM, Luciw PA: Induction of simian AIDS in infant rhesus macaques infected with CCR5- or CXCR4-utilizing simian-human immunodeficiency viruses is associated with distinct lesions of the thymus. J Virol 78:2121-2130, 2004
14. Kourtis AP, Ibegbu CC, Scinicariello F, Oh CY, McClure HM. SHIV-KB9 infection of rhesus monkeys does not always cause disease-contribution of host immune factors and thymic output. Virology 303: 47-57, 2002
15. Iida T, Ichimura H, Shimada T, Ibuki K, Ui M, Tamara K, Kuwata T, Yonehara S, Imanishi J, Hayami M: Role of apoptosis induction in both peripheral lymph nodes and thymus in progressive loss of CD4+ cells in SHIV-infected macaques. AIDS Res Hum Retroviruses 16:9-18, 2000
16. Sempowski G, Thomasch J, Gooding M, Hale L, Edwards L, Ciafaloni E, Sanders D, Massey J, Douek D, Koup R, Haynes B: Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis. J Immunol 166:2808-2817, 2001
17. Douek DC, Koup RA: Evidence for thymic function in the elderly. Vaccine 18:1638-1641, 2000
18. Hazenberg MD, Hamann D, Schuitemaker H, Miedema F: T cell depletion in HIV-1 infection: How CD4+ T cells go out of stock. Nat Immunol 1:285-289, 2000
19. Shevach EM: Certified professionals: CD4(+) CD25(+) suppressor T cells. J Exp Med 193:F41-F46, 2001
20. Suvas S, Kumaraguru U, Pack CD, Lee S, Rouse BT: CD4+ CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med 198:889-901, 2003
21. Aandahl EM, Michaelsson J, Moretto WJ, Hecht FM, Nixon DF: Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J Virol 78:2454-2459, 2004
22. Kinter AL, Hennessey M, Bell A, Kern S, Lin Y, Daucher M, Planta M, McGlaughlin M, Jackson R, Ziegler SF, Fauci AS: CD25(+) CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 200:331-343, 2004
23. Haynes BF, Hale LP, Weinhold KJ, Patel DD, Liao HX, Bressler PB, Jones DM, Demarest JF, Gebhard-Mitchell K, Haase AT, Bartlett JA: Analysis of the adult thymus in reconstitution of T lymphocytes in HIV- 1 infection. J Clin Invest 103:453-460, 1999
24. Markert ML, Alvarez-McLeod AP, Sempowski GD, Hale LP, Horvatinovich JM, Weinhold KJ, Bartlett JA, D'Amico TA, Haynes BF: Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy. AIDS Res Hum Retroviruses 17:1635-1643, 2001
25. Sempowski GD, Haynes BF: Immune reconstitution in patients with HIV infection. Ann Rev Med 53:269-284, 2002
26. Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LP: The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Ann Rev Immunol 18:529-560, 2000
27. Douek D: Thymic output and HIV infection: On the right TREC. Immunity 21:744-745, 2004
28. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA: Changes in thymic function with age and during the treatment of HIV infection. Nature 396:690-695, 1998
29. McCune JM, Loftus R, Schmidt DK, Carroll P, Webster D, Swor-Yim LB, Francis IR, Gross BH, Grant RM: High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest 101:2301-2308, 1998
30. Steinmann GG, Klaus B, Muller-Hermelink HK: The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol 22:563-575, 1985
31. Sempowski GD, Hale LP, Sundy JS, Massey JM, Koup RA, Douek DC, Patel DD, Haynes BF: Leukemia inhibitoiy factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J Immunol 164:2180-2187, 2000
32. Wong JK, Gunthard HF, Havlir DV, Zhang ZQ, Haase AT, Ignacio CC, Kwok S, Emini E, Richman DD: Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure. Proc Natl Acad Sci USA 94:12574-12579, 1997
33. Cossarizza A, Poccia F, Agrati C, D'Offizi G, Bugarini R, Pinti M, Borghi V, Mussini C, Esposito R, Ippolito G, Narciso P: Highly active antiretroviral therapy restores CD4+ Vbeta T-cell repertoire in patients with primary acute HIV infection but not in treatment-naive HIV+ patients with severe chronic infection. J Acquir Immune Defic Syndr 35:213-222, 2004