Analysis of the adult thymus in reconstitution of T lymphocytes in HIV- 1 infection

Journal of Clinical Investigation

Volumn 103, Issue 4, 1999, Pages 453-460

  Haynes, Barton F ^a,c   Hale, Laura P ^a   Weinhold, Kent J ^a   Patel, Dhavalkumar D ^a   Liao, Hua Xin ^a   Bressler, Peter B ^a   Jones, Dawn M ^a   Demarest, James F ^a   Gebhard Mitchell, Kristin ^b   Haase, Ashley T ^b   Bartlett, John A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; INDINAVIR; LAMIVUDINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CLINICAL ARTICLE; DISEASE COURSE; FEMALE; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INFLAMMATION; LYMPHOPOIESIS; MALE; PRIORITY JOURNAL; T LYMPHOCYTE; THYMECTOMY; THYMUS;

EID: 0033557266     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5201     Document Type: Article

References (42)

1. Haynes, B.F., Denning, S.M., Le, P.T., Singer, K.H. 1990. Human intrathymic T cell differentiation. Sem. Immunol. 2:67-77.
2. Mackall, C.L., et al. 1993. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymus-derived versus thymic-independent progeny. Blood. 82:2585-2594.
3. Mackall, C.L., et al. 1995. Age, thymopoiesis, and CD4+ T lymphocyte regeneration after intensive chemotherapy. N. Engl. J. Med. 332:143-149.
4. Mackall, C.L., Hakim, F.T., and Gress, R.E. 1997. T-cell regeneration: all repertoires are not created equal. Immunol. Today. 18:245-251.
5. Wei, X., et al. 1995. Viral dynamics in human immunodeficiency virus type I infection. Nature. 373:117-122.
6. Ho, D.D., et al. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 373:123-126.
7. Rosenberg, Y.J., Anderson, A.O., and Pabst, R. 1998. HIV-induced decline in blood CD4/CD8 ratios: viral killing or altered lymphocyte trafficking? Immunol. Today. 19:10-17.
8. Wolthers, K.C., Shuitemaker, H., and Miederna, F. 1998. Rapid CD4+ T-cell turnover in HIV-1 infection: a paradigm revisited. Immunol. Today. 19:44-48.
9. Autran, B., et al. 1997. Positive effects of combined antiretroviral therapy on CD4+ cell homeostasis and function in advanced HIV disease. Science. 277:112-116.
10. Connors, M., et al. 1997. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nat. Med. 3:533-540.
11. Hammer, S., et al. 1997. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. N. Engl. J. Med. 337:725-733.
12. Key, G., et al. 1993. New Ki-67 equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair repetitive elements encoding for the Ki-67 epitope. Lab. Invest. 68:629-636.
13. Tenner-Racz, K., et al. 1993. Cytotoxic effector cell granules recognized by monoclonal antibody TIA-1 are present in CD8+ lymphocytes in lymph nodes of human immunodeficiency virus-1 infected patients. Am. J. Pathol. 142:1750-1758.
14. Bartlett, J.A., et al. 1998. Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen in HIV-infected HLA B7 positive subjects. AIDS. 12:1291-1300.
15. Picker, L.J., et al. 1993. Control of lymphocyte recirculation in man. J. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition. J. Immunol. 150:1105-1121.
16. Cavert, W., et al. 1997. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science. 276:960-964.
17. Pantaleo, G., et al. 1994. Major expansion of CD8+ T lymphocytes with a predominant Vβ usage during the primary immune response to HIV. Nature. 370:463-467.
18. Dixon, A.K., et al. 1981. Computed tomography and histological correlation of the thymic remnant. Clin. Radiol. 32:255-257.
19. Moore, A.V., et al. 1983. Age-related changes in the thymus gland: CT-pathologic correlation. Am. J. Radiol. 141:241-246.
20. Kissin, C.M., Husband, J.E., Nicholas, D., Eversman, W. 1987. Benign thymic enlargement in adults after chemotherapy: CT demonstration. Thorac. Radiol. 163:67-70.
21. McCune, J.M., et al. 1998. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J. Clin. Invest. 101:2301-2308.
22. Haynes, B.F., et al. 1996. Toward an understanding of the correlates of protective immunity of HIV infection. Science. 271:324-328.
23. Wessel, H.B., and Zitelli, B.J. 1987. Myasthenia gravis associated with human T-cell lymphotropic virus type III infection. Ped. Neurol. 3:238-239.
24. Authier, F.-J., DeGrissac, N., Degos, J.-D., and Gherardi, R.K. 1995. Transient myasthenia gravis during HIV infection. Muscle Nerve. 18:914-916.
25. Pantaleo, G., et al. 1997. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc. Natl. Acad. Sci. USA. 94:254-258.
26. Pakker, N.G., et al. 1998. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1-infection: a composite of redistribution and proliferation. Nat. Med. 4:208-214.
27. Walker, R., et al. 1998. Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults. Nat. Med. 4:852-856.
28. Gorochov, G., et al. 1998. Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat. Med. 4:215-221.
29. Zhang, Z.Q., et al. 1998. Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection. Proc. Natl. Acad. Sci. USA. 5:1154-1159.
30. Douek, D.C., et al. 1998. Changes in thymic output with age and during the treatment of HIV infection. Nature. 396:690-695.
31. Seemayer, T.A., et al. 1984. Precocious thymic involution manifest by epithelial injury in the acquired immune deficiency syndrome. Hum. Pathol. 15:469-474.
32. Joshi, V.V., et al. 1984. Pathology of suspected acquired immune deficiency syndrome in children: a study of eight cases. Pediatr. Pathol. 2:71-87.
33. Joshi, V.V., and Oleske, J.M. 1985. Pathologic appraisal of the thymus gland in acquired immunodeficiency syndrome in children. Arch. Pathol. Lab. Med. 109:142-146.
34. Grody, W.W., Fligiel, S., and Naeim, F. 1985. Thymus involution in the acquired immunodeficiency syndrome. Am. J. Clin. Pathol. 84:85-95.
35. Savino, W., et al. 1986. Thymic epithelium in AIDS: an immunohistologic study. Am. J. Pathol. 122:302-307.
36. Linder, J. 1987. The thymus gland in secondary immunodeficiency. Arch. Pathol. Lab. Med. 111:1118-1122.
37. Schuurman, H.J., et al. 1989. The thymus in acquired immune deficiency syndrome: comparison with other types of immunodeficiency diseases, and presence of components of human immunodeficiency virus type 1. Am. J. Pathol. 134:1329-1338.
38. Burke, A. P., et al. 1995. Localization of human immunodeficiency virus 1 RNA in thymic tissues from asymptomatic drug addicts. Arch. Pathol. Lab. Med. 119:36-41.
39. Steinmann, G.G. 1986. Changes in the human thymus during aging. Curr. Top. Pathol. 75:43-88.
40. Bofill, M., et al. 1985. Microenvironments in the normal thymus and the thymus in myasthenia gravis. Am. J. Pathol. 119:462-473.
41. Haynes, B.F., and Hale, L.P. 1998. The human thymus: a chimeric organ comprised of central and peripheral lymphoid components. Immunol. Res. 18:61-78.
42. Kourtis, A.P., et al. 1996. Early progression of disease in HIV-infected infants with thymus dysfunction. N. Engl. J. Med. 335:1431-1436.