SCID-hu mice: A model for studying disseminated HIV infection

Seminars in Immunology

Volumn 8, Issue 4, 1996, Pages 223-231

  Goldstein, Harris ^a   Pettoello Mantovani, Massimo ^a   Katopodis, Nikos F ^a   Kim, Ana ^a   Yurasov, Sergey ^a   Kollmann, Tobias R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Bone marrow; Gene therapy; HIV; IL 10; IL 12; SCID mice; Thymus; Transplantation

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; BONE MARROW; CELL TRANSPLANTATION; COMBINED IMMUNODEFICIENCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONONUCLEAR CELL; MOUSE; NONHUMAN; REVIEW; SCID MOUSE; T LYMPHOCYTE; VIREMIA;

EID: 0030221187     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1996.0028     Document Type: Review

References (43)

1. 1. Pantalleo G, Graziosi C, Fauci AS (1993) The immunopathogenesis of human immunodeficiency virus infection. New Engl J Med 328:327-335
2. 2. McCune JM (1991) HIV-1: The infective process in vivo. Cell 64:351-363
3. 3. Fauci A (1993) Multifactorial nature of human immunodeficiency virus disease: Implications for therapy. Science 262:1011-1018
4. 4. Pantaleo G, Graziosi C, Butini L, Pizzo PA, Schnittman SM, Kotler DP, Fauci AS (1991) Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci 8:9838-9842
5. 5. Pantaleo G, Graziosi C, Demerest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS (1993) HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Science 362:355-358
6. 6. Embretson J, Zupanic M, Ribas JL, Burke A, Racz P, Tenner-Racz K, Haase AT (1993) Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Science 362:359-362
7. 7. Temin HM, Bolognesi DP (1993) Where has HIV been hiding? Nature 362:292-293
8. 8. Dalgleish AG (1993) Immunobiological aspects of HIV treatment. Curr Opin Immunol 5:608-614
9. 9. Namikawa R, Kaneshima H, Lieberman M, Weissman IL, McCune JM (1988) Infection of the SCID-hu mouse by HIV-1. Science 242:1684-1686
10. 10. McCune JM, Peault B, Streeter PR, Rabin L (1991) Preclinical evaluation of human hematolymphoid function in the SCID-hu mouse. Immunol Rev 124:45-62
11. 11. Krowka JF, Sarin S, Namikawa R, McCune JM, Kaneshima H (1991) Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent. J Immunol 146:3751-3756
12. 12. Namikawa R, Weilbaecher KN, Kaneshima H, Yee EJ, McCune JM (1990) Long-term hematopoiesis in the SCID mouse. J Exp Med 172:1055-1063
13. 13. Kollmann TR, Pettoello-Mantovani M, Zhuang X, Kim A, Hachamovitch M, Smarnworawong P, Rubinstein A, Goldstein H (1994) Disseminated HIV-1 infection in SCID-hu mice after peripheral inoculation with HIV-1. J Exp Med 179: 513-522
14. 14. Naparstek Y, Holoshitz J, Eisenstein S, Reshef T, Rappaport S, Chemke J, Ben-Nun A, Cohen IR (1982) Effector T lymphocyte line cells migrate to the thymus and persist there. Nature 300:262-264
15. 15. Fink PJ, Bevan MJ, Weissman IL (1984) Thymic cytotoxic T lymphocytes are primed in vivo to minor histocompatibility antigens. J Exp Med 159:436-451
16. 16. Hirokawa K, Utsuyama M, Sado T (1989) Immunohistological analysis of immigration of thymocyte-precursors into the thymus: evidence for immigration of peripheral T cells into the thymic medulla. Cell Immunol 119:160-170
17. 17. Zack JA, Arrigo SJ, Weitsman SR, Go AS, Haislip A, Chen ISY (1990) HIV-1 entry into quiescent primary lymphocytes. Cell 61:213-222
18. 18. Kollmann TR, Kim A, Pettoello-Mantovani M, Hachamovitch M, Rubinstein A, Goldstein MM, Goldstein H (1995) Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice. J Immunol 154:907-921
19. 19. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M (1995) Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-126
20. 20. Bonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, McCune JM, Kaneshima H (1993) HIV induces thymus depletion in vivo. Nature 363:728-732
21. 21. Aldrovandi GM, Feur G, Gao L, Jamieson B, Kristeva M, Chen ISY, Zack JA (1993) The SCID-hu mouse as a model for HIV-1 infection. Nature 363:732-736
22. 22. Kaneshima H, Lishan S, Bonyhadi ML, Conner RI, Ho DD, McCune JM (1994) Rapid-high, syncytium inducing isolates of HIV type 1 induce cytopathicity in the human thymus of the SCID-hu mouse. J Virol 68:8188-8192
23. 22a. Deng H, Liu R, Ellmeier, et al. Identification of a major coreceptor for primary isolates of HIV-1. Nature 381:661-666
24. + T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science 260:689-692
25. 24. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM (1995) Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117-122
26. 25. Coffin JM (1995) HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267:483-489
27. 26. Kollmann TR, Zhuang X, Hachamovitch M, Goldstein H (1994) Multilineage hematopoiesis and peripheral reconstitution of SCID mice with human lymphoid and myeloid cells following transplantation with human fetal bone marrow. Proc Natl Acad Sci USA 91:8032-8036
28. 27. D'Andrea AM, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Tinchieri G (1993) Interleukin 10 inhibits human lymphocyte interferon γ production by suppressing natural killer cell stimulatory factor/ IL-12 synthesis in accessory cells. J Exp Med 178:1041-1048
29. 28. Kubin M, Kamoun M, Trinchieri G (1994) Interleukin 12 synergizes with B7/ CD28 interaction in inducing efficient proliferation and cytokine production of human cells. J Exp Med 180:211-222
30. 29. Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospisil M, Young HA, Wolf SF, Young D, Clark SC, Trinchieri G (1991) Induction of interferon γ production by natural killer cell stimulatory factor: Characterizaton of the responder cells and synergy with other inducers. J Exp Med 173:869-879
31. 30. Wu C-Y, Demeure C, Kiniwa M, Gately M, Delespesse G (1993) IL-12 induces the production of INF-γ by neonatal human T cells. J Immunol 151:1938-1949
32. 31. Wang P, Wu P, Siegel MI, Egan RW, Billah MM (1994) IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J Immunol 153:811-816
33. 32. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR (1993) Interleukin-10. Annu Rev Immunol 11:165-190
34. 33. Kollmann TR, Pettoello-Mantovani M, Katopodis N, Kim A, Hachamovitch M, Goldstein H (1996) Demonstration of in vivo inhibition of HIV infection by treatment of SCID-hu mice with IL-10. Proc Natl Acad Sci USA 93:3126-3131
35. 34. Saville MW, Taga K, Foli A, Broder S, Tosato G, Yarchoan R (1994) Interleukin-10 suppresses human immunodeficiency virus-1 replication in vitro in cells of the monocyte/macrophage lineage. Blood 83:3591-3599
36. 35. Kootstra NA, Van't Wout AB, Huisman HG, Miedema F, Schuitemaker H (1994) Interference of interleukin-10 with human immunodeficiency virus type 1 replication in primary monocyte-derived macrophages. J Virol 68:6967-6975
37. 36. Yu M, Leavitt MC, Maruyama M, Yamada O, Young D, Ho AD, Wong-Staal F (1995) Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1. Proc Natl Acad Sci USA 92:699-1995
38. 37. Lapidot T, Pflumio F, Doedens M, Murdoch B, Williams DE, Dick JE (1992) Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID cells. Science 255:1137-1141
39. 38. Brashem CJ, Kersey JH, Bollum FJ, Lebien TW (1982) Ontogenic studies of lymphoid progenitor cells in human bone marrow. Exp Hematol 10:886
40. 39. Lansdorp PM, Dragowska W, Mayani H (1993) Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med 78:787 1993
41. 40. Kollmann TR, Goldstein MM, Goldstein H (1993) The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-Beige-Nude-xid mice is associated with the reconstitution of the murine immune system. J Exp Med 177:821-832
42. 41. Frey JR, Ernst B, Surh CD, Sprent J (1992) Thymus grafted SCID mice show transient thymopoiesis and limited depletion of Vβ11 + cells. J Exp Med 175:1067-1073
43. 42. Akkina RK, Rosenblatt JD, Campbell AG, Chen ISY, Zack JA (1994) Modeling human lymphoid precursor cell therapy in the SCID-hu mouse. Blood 84:1393