Molecular mechanism of ursolic acid induced apoptosis in poorly differentiated endometrial cancer HEC108 cells

Oncology Reports

Volumn 14, Issue 2, 2005, Pages 507-512

  Achiwa, Yumiko ^a   Hasegawa, Kiyoshi ^a   Udagawa, Yasuhiro ^a  

^a FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

Bax; Bcl 2; Caspase 3; Cytochrome c; Poorly differentiated type endometrial cancer cells; Ursolic acid

Indexed keywords

ACETYL ASPARTYL GLUTAMYL VALYL ASPARTAL; ACETYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTAL; ANTINEOPLASTIC AGENT; APAF1 PROTEIN, HUMAN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BAX PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASPASE; CASPASE 3; CYSTEINE PROTEINASE INHIBITOR; CYTOCHROME C; DNA FRAGMENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLIGOPEPTIDE; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; TRITERPENE; URSOLIC ACID;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENDOMETRIUM TUMOR; FEMALE; GENETICS; HUMAN; METABOLISM; PATHOLOGY; TIME; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; OLIGOPEPTIDES; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TIME FACTORS; TRITERPENES;

EID: 24744438501     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.14.2.507     Document Type: Article

References (37)

1. Pezzuto M: Plant-derived anticancer agents. Pharmacology 53: 121-133, 1997.
2. San S, Lapsley K and Rosen RT: Ho.Chi-T protein sample loading. New prenylated benzoic acid and other constituents from almond hulls (Prunusamygdalus batsch). J Agric Food Chem 5: 607-609, 2002. (Pubitemid 34106686)
3. Lee K, Lin Y, Wu T, Zhang D, Yamagishi Y, Hayashi T, Hall I, Chang J, Wu R and Yang T: The cytotoxic principles of Prunella vulgaris, Psychotriaserpens and Hyptis, ursolic acid and related derivaves. Planta Med 54: 308-311, 1988.
4. Taniguchi S, Imayoshi Y, Kobayashi E, Takamatu Y, Ito H, Hatano T, Sakagami H, Tokuda H, Nishino H, Sugita D, Shimura S and Yoshida T: Production of bioactive triterpenes by Eriobotrya Japonicacalli. Phytochemistry 59: 315-323, 2002. (Pubitemid 34145432)
5. Komiya T, Achiwa Y, Katuzaki H, Imai K, Sakurai S, Urakawa K, Onishi K, Adachi T, Yamada T and Hibasami H: Effect of oleanolic acid and ursolic acid isolated from loquat (Eriobotrya) on the growth of human leukemia cells. Food Sci Tech Int Tokyo 4: 282-284, 1998.
6. Hirota M, Mori T, Yoshida M and Iriye R: Suppression of tumor promoter-induced inflammation of mouse ear by ursolic acid and 4,4-dimethylcholestane derivatives. Agric Biol Chem 54: 1073-1075, 1990.
7. Ohigashi H, Takamura H, Koshimizu K, Tokud H and Ito Y: Search for possible antitumor promoters by inhibition of 12-O-tetradecanoyl phorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medical plant, Glechoma hederaceae. Cancer Lett 30: 143-151, 1986. (Pubitemid 16152810)
8. McConkey DJ and Orrnius S: Cellular signaling in thymocyte apoptosis. Cell Mol Biol 3: 227-246, 1991.
9. Cohen JJ: Programmed cell death in the immune system. Ad v Immunol 85: 50-55, 1991.
10. Eilee W: Life, death and the pursuit of apoptosis. Genes Dev 10: 1-15, 1996.
11. 2release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells. Int J Cancer 73: 725-728, 1997.
12. Lauthier F, Taille L, Trouillas P, Deleage C and Simon A: Ursolic acid triggers calcium-dependent apoptosis in human Daudi cells. Anticancer Drugs 11: 737-745, 2000.
13. Choi YH, Baek JH, Yoo AM, Chung HY, Kim ND and Kim KW: Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human-prostate epithelial cells. Int J Oncol 17: 555-571, 2000.
14. Kim DK, Back JH, Kang CM, Yoo MA, Sung JW, Kim DK, Chung HY, Kim ND, Choi Y H, Lee SH and Kim KW: Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA. Int J Cancer 87: 629-636, 2000.
15. Harmand P, Duval R, Liagre B, Jayat-Vignoles C, Beneytout J, deLageand C and Simon A: Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells. Int J Oncol 23: 105-112, 2000.
16. 1. Cancer Res Arch 63: 4375-4383, 2003.
17. Kauffman S, Desnoyer S, Ottaviano Y, Davidson N and Poirier G: Specific proteolytic cleavage of poly(ADP-ribouse) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 53: 3976-3985, 1993. (Pubitemid 23267698)
18. Lou AS: Programmed cell death (apoptosis) and response to anti-cancer drugs. Anticancer Drugs 5: 3-9, 1994.
19. Kerr JF, Wyllic AH and Curie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
20. Henning RS and Guys S: Properties of caspases. Biochem Biophys Acta 1387: 17-31, 1998.
21. Salvesen GS and Dixit VM: Caspase: intracellular signaling by proteolysis. Cell 9: 443-446, 1997.
22. Kaufman S: Hinduction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note. Cancer Res 49: 5870-5878, 1989.
23. Nicholson DW, Ali Thonberry NA, Vallancourt JP, Ding CK, Gallan M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smuison ME, Yamin TT, Yu V and Miller DK: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 36-43, 1995.
24. Antonsson B and Martinou J: The Bcl-2 protein family. Exp Cell Res 256: 50-57, 2000. (Pubitemid 30211166)
25. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T and Wang X: Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132, 1997. (Pubitemid 27097312)
26. Kluck R, Degli Esposi M, Perkins G, Renken C, Kuwana T, Bossy-Wetzel E, Goldberg M, Allen T, Barber M, Green D and Newmeyer D: The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondria outer membrane that is enhanced by cytosol. J Cell Biol 147: 809-822, 1999.
27. Li P, Nijhawan D, Budihardio I, Srinivasa SM, Ahmad M, Emad S, Alnemri ES and Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997. (Pubitemid 27508237)
28. Thornberr NA and Lazebni KY: Caspase: enemies within. Science 128: 312-316, 1998.
29. Zou H, Jhenzel W, Liu X, Lutschg A and Wang X: Apaf-1, human protein homologous to C. elegans CED-4, participates cytochrome c-dependent activation of caspase-3. Cell 90: 405-413, 1997. (Pubitemid 27347231)
30. Adams J and Cory S: The Bcl-2 protein family: arbiters of cell survival. Science 28: 1322-1326, 1998. (Pubitemid 28406819)
31. Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
32. Jugensmeier JM, Xie Z, Deveraux E, Ibredesen D and Reed JC: Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 95: 4997-5002, 1998 . (Pubitemid 28208539)
33. Wolter K, Hsu Y, Smith C, Nechushtan A, Xi XJ and Youle R: Movement of Bax from the cytosol to mitochondria during apoptosis. Cell Biol 139: 1281-1292, 1997. (Pubitemid 27523214)
34. Oltval Z, Miliman C and Korsmeyer S: Bcl-2 heterodimers in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 4: 609-619, 1999.
35. Kluck RM, Bossy-Wetzel E, Gree DR and Newmeyer DD: The release of cytochrome c form mitochondria: a primary site for bcl-2 regulation of apoptosis. Science 27: 1132-1136, 1997. (Pubitemid 27097313)
36. Green D and Reed J: Mitochondria and apoptosis. Science 281: 1309-1312, 1998. (Pubitemid 28406816)
37. Wolf B, Schuler M, Li W, Enggers-Sedlet B, Lee W, Tailor P, Fitzagerald P, Mills G and Green D: Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity. J Biol Chem 276: 34244-34251, 2001.