Induction of apoptosis by spermine-metabolites in primary human blood cells and various tumor cell lines

Apoptosis

Volumn 10, Issue 5, 2005, Pages 1151-1162

  Schiller, M ^a   Blank, N ^a   Heyder, P ^a   Herrmann, M ^b   Gaipl, U S ^b   Kalden, J R ^b   Lorenz, H M ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Aldehyde; Apoptosis; Caspase; Polyamine; Spermine

Indexed keywords

ACETYLCYSTEINE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING); AMINOGUANIDINE; CASPASE; CYTOCHROME C; GLUTATHIONE; POLYAMINE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SPERMINE;

APOPTOSIS; ARTICLE; BLOOD CELL; CANCER CELL CULTURE; CATABOLISM; CONTROLLED STUDY; ENZYME BLOOD LEVEL; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE;

ACETYLCYSTEINE; AMINE OXIDASE (COPPER-CONTAINING); AMINO ACID CHLOROMETHYL KETONES; ANTIGENS, CD95; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; DEXAMETHASONE; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES, MONONUCLEAR; LYMPHOPROLIFERATIVE DISORDERS; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; POLYAMINES; PROTO-ONCOGENE PROTEINS C-BCL-2; PUTRESCINE; REACTIVE OXYGEN SPECIES; SPERMIDINE; SPERMINE;

EID: 24644524094     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-005-1188-5     Document Type: Article

References (68)

1. Wallace HM. The physiological role of the polyamines. Eur J Clin Invest 2000; 30: 1-3.
2. Igarashi K, Kashiwagi K. Polyamines: Mysterious modulators of cellular functions. Biochem Biophys Res Commun 2000; 271: 559-564.
3. Kramer DL, Chang BD, Chen Y, et al. Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype. Cancer Res 2001; 61: 7754-7762.
4. Nishimura K, Murozumi K, Shirahata A, Park MH, Kashiwagi K, Igarashi K. Independent roles of eIF5A and polyamines in cell proliferation. Biochem J 2005; 385: 779-785.
5. Williams K. Interactions of polyamines with ion channels. Biochem J 1997; 325: 289-297.
6. Stanfield PR, Sutcliffe MJ. Spermine is fit to block inward rectifier (Kir) channels. J Gen Physiol 2003; 122: 481-484.
7. +) transport. Biochim Biophys Acta 2004; 1661: 113-124.
8. Pegg AE. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res 1988; 48: 759-774.
9. Igarashi K, Kashiwagi K. Polyamine transport in bacteria and yeast. Biochem J 1999; 344: 633-642.
10. Murakami Y, Matsufuji S, Hayashi S, Tanahashi N, Tanaka K. Degradation of ornithine decarboxylase by the 26S proteasome. Biochem Biophys Res Commun 2000; 267: 1-6.
11. Babal P, Ruchko M, Campbell CC, et al. Regulation of ornithine decarboxylase activity and polyamine transport by agmatine in rat pulmonary artery endothelial cells. J Pharmacol Exp Ther 2001; 296: 372-377.
12. Suzuki T, He Y, Kashiwagi K, Murakami Y, Hayashi S, Igarashi K. Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells. Proc Natl Acad Sci USA 1994; 91: 8930-8934.
13. Dai H, Kramer DL, Yang C, Murti KG, Porter CW, Cleveland JL. The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects. Cancer Res 1999; 59: 4944-4954.
14. Schipper RG, Penning LC, Verhofstad AA. Involvement of polyamines in apoptosis. Facts and controversies: Effectors or protectors? Semin Cancer Biol 2000; 10: 55-68.
15. Zhang M, Wang H, Tracey KJ. Regulation of macrophage activation and inflammation by spermine: A new chapter in an old story. Crit Care Med 2000; 28: N60-66.
16. Weiss TS, Herfarth H, Obermeier F, et al. Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease. Inflamm Bowel Dis 2004; 10: 529-535.
17. Bachrach U. Polyamines and cancer: Minireview article. Amino Acids 2004; 26: 307-309. Epub 2004 Jun 2022.
18. Hu RH, Pegg AE. Rapid induction of apoptosis by deregulated uptake of polyamine analogues. Biochem J 1997; 328: 307-316.
19. Poulin R, Pelletier G, Pegg AE. Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells. Biochem J 1995; 311: 723-727.
20. Ha HC, Woster PM, Yager JD, Casero RA, Jr. The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc Natl Acad Sci USA 1997; 94: 11557-11562.
21. Monti MG, Ghiaroni S, Pernecco L, Barbieri D, Marverti G, Franceschi C. Polyamine depletion protects HL-60 cells from 2-deoxy-D-ribose-induced apoptosis. Life Sci 1998; 62: 799-806.
22. Desiderio MA, Grassilli E, Bellesia E, Salomoni P, Franceschi C. Involvement of ornithine decarboxylase and polyamines in glucocorticoid- induced apoptosis of rat thymocytes. Cell Growth Differ 1995; 6: 505-513.
23. Redman C, Xu MJ, Peng YM, et al. Involvement of polyamines m selenomethionine induced apoptosis and mitotic alterations in human tumor cells. Carcinogenesis 1997; 18: 1195-1202.
24. Lindsay GS, Wallace HM. Changes in polyamine catabolism in HL-60 human promyelogenous leukaemic cells in response to etoposide-induced apoptosis. Biochem J 1999; 337: 83-87.
25. Penning LC, Schipper RG, Vercammen D, et al. Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. Cytokine 1998; 10: 423-431.
26. Paul B, Hayes CS, Kim A, Athar M, Gilmour SK. Elevated polyamines lead to selective induction of apoptosis and inhibition of tumorigenesis by (-)-epigallocatechin-3-gallate (EGCG) in ODC/Ras transgenic mice. Carcinogenesis 2005; 26: 119-124. Epub 2004 Sep 2016.
27. Stefanelli C, Bonavita F, Stanic I, et al. Spermine causes caspase activation in leukaemia cells. FEBS Lett 1998; 437: 233-236.
28. Stefanelli C, Stanic I, Zini M, et al. Polyamines directly induce release of cytochrome c from heart mitochondria. Biochem J 2000; 347: 875-880.
29. Chen Y, Kramer DL, Diegelman P, Vujcic S, Porter CW. Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells. Cancer Res 2001; 61: 6437-6444.
30. Agostinelli E, Przybytkowski E, Averill-Bates DA. Glucose, glutathione, and cellular response to spermine oxidation products. Free Radic Biol Med 1996; 20: 649-656.
31. Sharmin S, Sakata K, Kashiwagi K, et al. Polyamine cytotoxicity in the presence of bovine serum amine oxidase. Biochem Biophys Res Commun 2001; 282: 228-235.
32. Bonneau MJ, Poulin R. Spermine oxidation leads to necrosis with plasma membrane phosphatidylserine redistribution in mouse leukemia cells. Exp Cell Res 2000; 259: 23-34.
33. Wallace HM, Fraser AV, Hughes A. A perspective of polyamine metabolism. Biochem J 2003; 376: 1-14.
34. Rigobello MP, Toninello A, Siliprandi D, Bindoli A. Effect of spermine on mitochondrial glutathione release. Biochem Biophys Res Commun 1993; 194: 1276-1281.
35. Toninello A, Salvi M, Mondovi B. Interaction of biologically active amines with mitochondria and their role in the mitochondrial-mediated pathway of apoptosis. Curr Med Chem 2004; 11: 2349-2374.
36. Agostinelli E, Arancia G, Vedova LD, et al. The biological functions of polyamine oxidation products by amine oxidases: Perspectives of clinical applications. Amino Acids 2004; 27: 347-358. Epub 2004 Aug 2019.
37. Arancia G, Calcabrini A, Marra M, et al. Mitochondrial alterations induced by serum amine oxidase and spermine on human multidrug resistant tumor cells. Amino Acids 2004; 26: 273-282. Epub 2003 Dec 2022.
38. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991; 139: 271-279.
39. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994; 84: 1415-1420.
40. Zamzami N, Marchetti P, Castedo M, et al. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med 1995; 181: 1661-1672.
41. Lenardo M, Chan KM, Hornung F, et al. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment. Annu Rev Immunol 1999; 17: 221-253.
42. Dorrie J, Schuh W, Keil A, et al. Regulation of CD95 expression and CD95-mediated cell death by interferon-gamma in acute lymphoblastic leukemia with chromosomal translocation t(4;11). Leukemia 1999; 13: 1539-1547.
43. Alas S, Bonavida B. Inhibition of Constitutive STAT3 Activity Sensitizes Resistant Non-Hodgkin's Lymphoma and Multiple Myeloma to Chemotherapeutic Drug-mediated Apoptosis. Clin Cancer Res 2003; 9: 316-326.
44. Haas JP, Grunke M, Frank C, et al. Increased spontaneous in vitro apoptosis in double negative T cells of humans with a fas/apo-1 mutation. Cell Death Differ 1998; 5: 751-757.
45. Hieronymus T, Blank N, Gruenke M, et al. CD95-independent mechanisms of IL-2 deprivation-induced apoptosis in activated human lymphocytes. Cell Death Differ 2000; 7: 538-547.
46. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000; 6: 513-519.
47. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 1997; 3: 614-620.
48. Cohen GM. Caspases: The executioners of apoptosis. Biochem J 1997; 326: 1-16.
49. Nicholson DW, Thornberry NA. Caspases: Killer proteases. Trends Biochem Sci 1997; 22: 299-306.
50. Lum MG, Nagley P. Two phases of signalling between mitochondria during apoptosis leading to early depolarisation and delayed cytochrome c release. J Cell Sci 2003; 116: 1437-1447.
51. Adrain C, Creagh EM, Martin SJ. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. Embo J 2001; 20: 6627-6636.
52. Uren RT, Dewson G, Bonzon C, Lithgow T, Newmeyer DD, Kluck RM. Mitochondrial release of pro-apoptotic proteins: Electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes. J Biol Chem 2005; 280: 2266-2274. Epub 2004 Nov 2269.
53. Carmody RJ, Cotter TG. Signalling apoptosis: A radical approach. Reclox Rep 2001; 6: 77-90.
54. Briehl MM, Baker AF, Siemankowski LM, Morreale J. Modulation of antioxidant defenses during apoptosis. Oncol Res 1997; 9: 281-285.
55. Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000; 29: 222-230.
56. Yu Z, Li W, Brunk UT. 3-Aminopropanal is a lysosomotropic aldehyde that causes oxidative stress and apoptosis by rupturing lysosomes. Apmis 2003; 111: 643-652.
57. Siesjo BK, Elmer E, Janelidze S, et al. Role and mechanisms of secondary mitochondrial failure. Acta Neurochir Suppl 1999; 73: 7-13.
58. Kim JS, He L, Lemasters JJ. Mitochondrial permeability transition: A common pathway to necrosis and apoptosis. Biochem Biophys Res Commun 2003; 304: 463-470.
59. Hou MH, Lin SB, Yuann JM, Lin WC, Wang AH, Kan Ls L. Effects of polyamines on the thermal stability and formation kinetics of DNA duplexes with abnormal structure. Nucleic Acids Res 2001; 29: 5121-5128.
60. Rudra PK, Krokan HE. Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells. Anticancer Res 1999; 19: 461-469.
61. McCloskey DE, Casero RA, Jr., Woster PM, Davidson NE. Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue. Cancer Res 1995; 55: 3233-3236.
62. McCloskey DE, Yang J, Woster PM, Davidson NE, Casero RA, Jr. Polyamine analogue induction of programmed cell death in human lung tumor cells. Clin Cancer Res 1996; 2: 441-446.
63. Casero RA, Jr., Pegg AE. Spermidine/spermine N1-acetyltransferase - the turning point in polyamine metabolism. Faseb J 1993; 7: 653-661.
64. Zhang HG, Wang J, Yang X, Hsu HC, Mountz JD. Regulation of apoptosis proteins in cancer cells by ubiquitin. Oncogene 2004; 23: 2009-2015.
65. Yang Y, Yu X. Regulation of apoptosis: The ubiquitous way. Faseb J 2003; 17: 790-799.
66. Breitschopf K, Haendeler J, Malchow P, Zeiher AM, Dimmeler S. Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: Molecular characterization of the involved signaling pathway. Mol Cell Biol 2000; 20: 1886-1896.
67. Kowaltowski AJ, Fenton RG, Fiskum G. Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radic Biol Med 2004; 37: 1845-1853.
68. Marsh SA, Laursen PB, Pat BK, Gobe GC, Coombes JS. Bcl-2 in endothelial cells is increased by vitamin E and alpha-lipoic acid supplementation but not exercise training. J Mol Cell Cardiol 2005; 38: 445-451.