Enhancement of growth and survival and alterations in Bcl-family proteins in β-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives

Blood Cells, Molecules, and Diseases

Volumn 35, Issue 2, 2005, Pages 217-226

  Castaneda, Serguei ^b   Boosalis, Michael S ^b   Emery, David ^b   Thies, Allison ^b   Faller, Douglas V ^b   Perrine, Susan P ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

thalassemia; Bcl family protein; Erythroid; Fatty acid; Growth; Survival

Indexed keywords

2 (QUINAZOLIN 4 YLAMINO)BUTYRIC ACID; [4 [(TRIFLUOROMETHYL)SULFANYL]ANILINO]ACETIC ACID; BUTYRIC ACID; CYTOKINE; FATTY ACID DERIVATIVE; GLOBIN; ISOPROTEIN; MITOGENIC AGENT; PROTEIN BCL XL; PROTEIN INHIBITOR; PROTEIN MCL 1; RB 3; RB 4; SHORT CHAIN FATTY ACID; SODIUM 2,2 DIMETHYLBUTYRATE; SODIUM 3,4 (METHYLENEDIOXY)CINNAMATE; SODIUM ALPHA METHYLHYDROCINNAMATE; ST 20; ST 7; ST 79; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BETA THALASSEMIA; CELL CULTURE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ERYTHROID PRECURSOR CELL; EXPOSURE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION;

ANIMALS; BCL-X PROTEIN; BETA-THALASSEMIA; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CYTOKINES; ERYTHROID PROGENITOR CELLS; FATTY ACIDS, VOLATILE; GENE EXPRESSION REGULATION; MICE; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 24644449060     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2005.06.007     Document Type: Article

References (41)

1. M.H. Steinberg, and G.P. Rodgers Pharmacologic modulation of fetal hemoglobin Medicine 80 2001 328 344
2. A.F. Collins, H.A. Pearson, P. Giardina, K.T. Mcdonagh, S.W. Brusilow, and G.J. Dover Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial Blood 85 1995 39 43
3. M.D. Cappellini Oral isobutyramide therapy in patients with thalassemia intermedia: results of a phase II open study Blood Cells Mol. Dis. 26 2000 105 111
4. C.H. Lowrey, and A.W. Nienhuis Brief report: treatment with azacytidine of patients with end-stage β-thalassemia N. Engl. J. Med. 329 1993 945
5. C. Dunbar, W. Travis, Y.W. Kan, and A.W. Nienhuis 5-Azacytidine treatment in a beta thalassemia patient unable to be transfused due to multiple allo-antibodies Br. J. Haematol. 74 1989 467
6. S.T. Singer, N. Sweeters, E. Vichinsky, E.A. Wagner, and E.A. Rachmilewitz A dose-finding and safety study of darbopoietin alfa (erythropoiesis stimulating protein) for the treatment of anemia in patients with thalassemia intermedia Blood 102 2003 268
7. P. Pootrakul A correlation of erythrokinetics, ineffective erythropoiesis, and erythroid precursor apoptosis in thai patients with thalassemia Blood 96 2000 2606 2612
8. G.P. Rodgers, and Y. Saunthararajah Advances in experimental treatment of beta-thalassaemia Expert Opin. Investig. Drugs 10 2001 925 934
9. S.P. Perrine Butyrate + EPO in beta thalassemia intermedia: interim findings of a phase II trial Blood 100 2002 47
10. S.L. Schrier Pathobiology of thalassemic erythrocytes Curr. Opin. Hematol. 4 1997 75 78
11. J. Yuan Accelerated programmed cell death (apoptosis) in erythroid precursors of patients with severe beta-thalassemia Blood 82 1993 374 377
12. F. Centis The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with beta-thalassemia major Blood 96 2000 3624 3629
13. S. Wittich Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells J. Med. Chem. 45 2002 3296 3309
14. C. Vaziri, L. Stice, and D.V. Faller Butyrate-induced G(1) arrest results from p21-independent disruption of retinoblastoma protein-mediated signals Cell Growth Differ. 9 1998 465 474
15. C.R. Mork, R.A. Spanjaard, and D.V. Faller A mechanistic approach to anticancer therapy: targeting the cell cycle with histone deacetylase inhibitors Curr. Pharm. Des. 11 2005 1091 1104
16. J.S. Chen, and D.V. Faller Histone deacetylase inhibition-mediated post-translational elevation of p27Kip1 protein levels is required for G1 arrest in fibroblasts J. Cell. Physiol. 202 2005 87 99
17. D.W. Emery Selection with a regulated cell growth switch increases the likelihood of expression for a linked gamma-globin gene Blood Cells Mol. Dis. 34 2005 235 247
18. B. Pace, Q.L. Li, K. Peterson, and G. Stamatoyannopoulos alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse Blood 84 1994 4344 4353
19. M.S. Boosalis Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation Blood 97 2001 3259 3267
20. T. Kitamura Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin J. Cell. Physiol. 140 1989 323 334
21. M.J. Koury, S.T. Sawyer, and S.J. Brandt New insights into erythropoiesis Curr. Opin. Hematol. 9 2002 93 100
22. M. Silva, D. Grillot, A. Benito, C. Richard, G. Nunez, and J.L. FernandezLuna Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-X(L) and Bcl-2 Blood 88 1996 1576 1582
23. M. Silva Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines J. Biol. Chem. 274 1999 22165 22169
24. C. Tian, P. Gregoli, and M. Bondurant The function of the bcl-x promoter in erythroid progenitor cells Blood 101 2003 2235 2242
25. A. Zeuner Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins Blood 102 2003 87 93
26. S. Sawatsri, D. Samid, S. Malkapuram, and N. Sidell Inhibition of estrogen-dependent breast cell responses with phenylacetate Int. J. Cancer 93 2001 687 692
27. D. Josefsen, J.H. Myklebust, J. Lomo, M. Sioud, H.K. Blomhoff, and E.B. Smeland Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells Stem. Cells 18 2000 261 272
28. R. Bernards Tumorigenicity of cells transformed by Adenovirus type 12 by evasion of T-cell immunity Nature 305 1983 776 779
29. T. Ikuta, Y.W. Kan, P.S. Swerdlow, D.V. Faller, and S.P. Perrine Alterations in protein-DNA interactions in the gamma-globin gene promoter in response to butyrate therapy Blood 92 1998 2924 2933
30. G.F. Atweh Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease Blood 93 1999 1790 1797
31. L.M. Khachigian, J.W.U. Fries, M.W. Benz, D.T. Bonthron, and T. Collins Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells J. Biol. Chem. 269 1994 22647 22656
32. N.F. Olivieri Treatment of thalassaemia major with phenylbutyrate and hydroxyurea Lancet 350 1997 491 492
33. F.M. Hajjar, and H.A. Pearson Pharmacologic treatment of thalassemia intermedia with hydroxyurea J. Pediatr. 125 1994 490 492
34. M. Silva, C. Richard, A. Benito, C. Sanz, I. Olalla, and J.L. Fernandez-Luna Expression of Bcl-x in erythroid precursors from patients with polycythemia vera N. Engl. J. Med. 338 1998 564 571
35. D.T. Chao, and S.J. Korsmeyer BCL-2 Family: regulators of cell death Annu. Rev. Immunol. 16 1998 395 419
36. S.J. Korsmeyer BCL-2 gene family and the regulation of cell death Int. J. Radiat. Oncol., Biol., Phys. 39 1997 98
37. J.T. Opferman, and S.J. Korsmeyer Apoptosis in the development and maintenance of the immune system Nat. Immunol. 4 2003 410 415
38. K. Paiboonsukwong The signaling pathways of erythropoietin and interferon-gamma differ in preventing the apoptosis of mature erythroid progenitor cells Int. J. Hematol. 78 2003 421 428
39. M. Mori Activation of extracellular signal-regulated kinases ERK1 and ERK2 induces Bcl-xL up-regulation via inhibition of caspase activities in erythropoietin signaling J. Cell. Physiol. 195 2003 290 297
40. M. Socolovsky, H. Nam, M.D. Fleming, V.H. Haase, C. Brugnara, and H.F. Lodish Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts Blood 98 2001 3261 3273
41. J.E. Parker, G.J. Mufti, F. Rasool, A. Mijovic, S. Devereux, and A. Pagliuca The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS Blood 96 2000 3932 3938