-
2
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3:1301-1306
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 1301-1306
-
-
Betarbet, R.1
Sherer, T.B.2
MacKenzie, G.3
Garcia-Osuna, M.4
Panov, A.V.5
Greenamyre, J.T.6
-
3
-
-
0034602176
-
Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta-and gamma-synuclein and cannot cross-seed its homologs
-
Biere AL, Wood SJ, Wypych J, Steavenson S, Jiang Y, Anafi D, Jacobsen FW, Jarosinski MA, Wu GM, Louis JC, Martin F, Narhi LO, Citron M (2000) Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta-and gamma-synuclein and cannot cross-seed its homologs. J Biol Chem 275:34574-34579
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34574-34579
-
-
Biere, A.L.1
Wood, S.J.2
Wypych, J.3
Steavenson, S.4
Jiang, Y.5
Anafi, D.6
Jacobsen, F.W.7
Jarosinski, M.A.8
Wu, G.M.9
Louis, J.C.10
Martin, F.11
Narhi, L.O.12
Citron, M.13
-
4
-
-
0035880007
-
Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins
-
Butterfield DA, Kanski J (2001) Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech Ageing Dev 122:945-962
-
(2001)
Mech. Ageing Dev.
, vol.122
, pp. 945-962
-
-
Butterfield, D.A.1
Kanski, J.2
-
5
-
-
0034776095
-
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease
-
Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM (2001) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med 7:1144-1150
-
(2001)
Nat. Med.
, vol.7
, pp. 1144-1150
-
-
Chung, K.K.1
Zhang, Y.2
Lim, K.L.3
Tanaka, Y.4
Huang, H.5
Gao, J.6
Ross, C.A.7
Dawson, V.L.8
Dawson, T.M.9
-
6
-
-
0037022186
-
Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro
-
Cohlberg JA, Li J, Uversky VN, Fink AL (2002) Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro. Biochemistry 41:1502-1511
-
(2002)
Biochemistry
, vol.41
, pp. 1502-1511
-
-
Cohlberg, J.A.1
Li, J.2
Uversky, V.N.3
Fink, A.L.4
-
7
-
-
0031728689
-
Synthetic filaments assembled from C-terminally truncated alpha-synuclein
-
Crowther RA, Jakes R, Spillantini MG, Goedert M (1998) Synthetic filaments assembled from C-terminally truncated alpha-synuclein. FEBS Lett 436:309-312
-
(1998)
FEBS Lett.
, vol.436
, pp. 309-312
-
-
Crowther, R.A.1
Jakes, R.2
Spillantini, M.G.3
Goedert, M.4
-
8
-
-
0034613450
-
Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain
-
Crowther RA, Daniel SE, Goedert M (2000) Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain. Neurosci Lett 292:128-130
-
(2000)
Neurosci. Lett.
, vol.292
, pp. 128-130
-
-
Crowther, R.A.1
Daniel, S.E.2
Goedert, M.3
-
9
-
-
0032952414
-
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
-
Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravi RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA (1999) Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat Genet 22:110-114
-
(1999)
Nat. Genet.
, vol.22
, pp. 110-114
-
-
Engelender, S.1
Kaminsky, Z.2
Guo, X.3
Sharp, A.H.4
Amaravi, R.K.5
Kleiderlein, J.J.6
Margolis, R.L.7
Troncoso, J.C.8
Lanahan, A.A.9
Worley, P.F.10
Dawson, V.L.11
Dawson, T.M.12
Ross, C.A.13
-
10
-
-
0033863483
-
Organization of the human synphilin-1 gene, a candidate for Parkinson's disease
-
Engelender S, Wanner T, Kleiderlein JJ, Wakabayashi K, Tsuji S, Takahashi H, Ashworth R, Margolis RL, Ross CA (2000) Organization of the human synphilin-1 gene, a candidate for Parkinson's disease. Mamm Genome 11:763-766
-
(2000)
Mamm. Genome
, vol.11
, pp. 763-766
-
-
Engelender, S.1
Wanner, T.2
Kleiderlein, J.J.3
Wakabayashi, K.4
Tsuji, S.5
Takahashi, H.6
Ashworth, R.7
Margolis, R.L.8
Ross, C.A.9
-
11
-
-
0034704752
-
A Drosophila model of Parkinson's disease
-
Feany MB, Bender WW (2000) A Drosophila model of Parkinson's disease. Nature 404:394-398
-
(2000)
Nature
, vol.404
, pp. 394-398
-
-
Feany, M.B.1
Bender, W.W.2
-
12
-
-
0035951869
-
A Hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
-
Giasson BI, Murray IV, Trojanowski JQ, Lee VM-Y (2001) A Hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J Biol Chem 276:2380-2386
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2380-2386
-
-
Giasson, B.I.1
Murray, I.V.2
Trojanowski, J.Q.3
Lee, V.M.-Y.4
-
14
-
-
0343527226
-
Alpha-Synuclein immunoreactivity in dementia with Lewy bodies: Morphological staging and comparison with ubiquitin immunostaining
-
Gomez-Tortosa E, Newell K, Irizarry MC, Sanders JL, Hyman BT (2000) Alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol (Berl) 99:352-357
-
(2000)
Acta Neuropathol. (Berl)
, vol.99
, pp. 352-357
-
-
Gomez-Tortosa, E.1
Newell, K.2
Irizarry, M.C.3
Sanders, J.L.4
Hyman, B.T.5
-
15
-
-
0035950270
-
Beta-Synuclein inhibits alpha-synuclein aggregation. A possible role as an anti-parkinsonian factor
-
Hashimoto M, Rockenstein E, Mante M, Mallory M, Masliah E (2001) Beta-Synuclein inhibits alpha-synuclein aggregation. A possible role as an anti-parkinsonian factor. Neuron 32:213-223
-
(2001)
Neuron
, vol.32
, pp. 213-223
-
-
Hashimoto, M.1
Rockenstein, E.2
Mante, M.3
Mallory, M.4
Masliah, E.5
-
16
-
-
0037025102
-
Immunohistochemical study of synphilin-1 in brains of patients with dementia with Lewy bodies - Synphilin-1 is non-specifically implicated in the formation of different neuronal cytoskeletal inclusions
-
Iseki E, Takayama N, Furukawa Y, Marui W, Nakai T, Miura S, Ueda K, Kosaka K (2002) Immunohistochemical study of synphilin-1 in brains of patients with dementia with Lewy bodies - synphilin-1 is non-specifically implicated in the formation of different neuronal cytoskeletal inclusions. Neurosci Lett 326:211-215
-
(2002)
Neurosci. Lett.
, vol.326
, pp. 211-215
-
-
Iseki, E.1
Takayama, N.2
Furukawa, Y.3
Marui, W.4
Nakai, T.5
Miura, S.6
Ueda, K.7
Kosaka, K.8
-
17
-
-
0031687793
-
Understanding cell death in Parkinson's disease
-
Jenner P, Olanow CW (1998) Understanding cell death in Parkinson's disease. Ann Neurol 44:S72-S84
-
(1998)
Ann. Neurol.
, vol.44
-
-
Jenner, P.1
Olanow, C.W.2
-
18
-
-
0035191413
-
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
-
Kahle PJ, Neumann M, Ozmen L, Muller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C (2001) Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol 159:2215-2225
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 2215-2225
-
-
Kahle, P.J.1
Neumann, M.2
Ozmen, L.3
Muller, V.4
Odoy, S.5
Okamoto, N.6
Jacobsen, H.7
Iwatsubo, T.8
Trojanowski, J.Q.9
Takahashi, H.10
Wakabayashi, K.11
Bogdanovic, N.12
Riederer, P.13
Kretzschmar, H.A.14
Haass, C.15
-
19
-
-
0034996655
-
Interaction of alpha-synuclein and synphilin-1: Effect of Parkinson's disease-associated mutations
-
Kawamata H, McLean PF, Sharma N, Hyman BT (2001) Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations. J Neurochem 77:929-39
-
(2001)
J. Neurochem.
, vol.77
, pp. 929-939
-
-
Kawamata, H.1
McLean, P.F.2
Sharma, N.3
Hyman, B.T.4
-
20
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18:106-108
-
(1998)
Nat. Genet.
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
Przuntek, H.7
Epplen, J.T.8
Schols, L.9
Riess, O.10
-
21
-
-
0034681471
-
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders
-
Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L (2000) Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 287:1265-1269
-
(2000)
Science
, vol.287
, pp. 1265-1269
-
-
Masliah, E.1
Rockenstein, E.2
Veinbergs, I.3
Mallory, M.4
Hashimoto, M.5
Takeda, A.6
Sagara, Y.7
Sisk, A.8
Mucke, L.9
-
22
-
-
0023517015
-
Synthesis and sequence-specific proteolysis of hybrid proteins produced in Escherichia coli
-
Nagai K, Thogersen HC (1987) Synthesis and sequence-specific proteolysis of hybrid proteins produced in Escherichia coli. Methods Enzymol 153:461-481
-
(1987)
Methods Enzymol.
, vol.153
, pp. 461-481
-
-
Nagai, K.1
Thogersen, H.C.2
-
23
-
-
0037036195
-
Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid-galactosidase liquid assay
-
Neystat M, Rzhetskaya M, Kholodilov N, Burke R (2002) Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid-galactosidase liquid assay. Neurosci Lett 325:119-123
-
(2002)
Neurosci. Lett.
, vol.325
, pp. 119-123
-
-
Neystat, M.1
Rzhetskaya, M.2
Kholodilov, N.3
Burke, R.4
-
24
-
-
0035900882
-
Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells
-
O'Farrell C, Murphy DD, Petrucelli L, Singleton AB, Hussey J, Farrer M, Hardy J, Dickson DW, Cookson MR (2001) Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells. Brain Res Mol Brain Res 97:94-102
-
(2001)
Brain Res. Mol. Brain Res.
, vol.97
, pp. 94-102
-
-
O'Farrell, C.1
Murphy, D.D.2
Petrucelli, L.3
Singleton, A.B.4
Hussey, J.5
Farrer, M.6
Hardy, J.7
Dickson, D.W.8
Cookson, M.R.9
-
25
-
-
0006890201
-
Preparation and extraction of insoluble (inclusion body) proteins from Escherichia coli
-
Coligan JE, Dunn BM, Ploegh HL, Speicher DW, Wingfield PT (eds) Wiley, New York
-
Palmer I, Wingfield PT (1995) Preparation and extraction of insoluble (inclusion body) proteins from Escherichia coli. In: Coligan JE, Dunn BM, Ploegh HL, Speicher DW, Wingfield PT (eds) Current protocols in protein science. Wiley, New York, pp 6.3.1-6.3.15
-
(1995)
Current Protocols in Protein Science
-
-
Palmer, I.1
Wingfield, P.T.2
-
26
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
27
-
-
0037189591
-
Synphilin-1 is developmentally localized to synaptic terminals and its association with synaptic vesicles is modulated by alpha-synuclein
-
Ribeiro CS, Carneiro K, Ross CA, Menezes JR, Engelender S (2002) Synphilin-1 is developmentally localized to synaptic terminals and its association with synaptic vesicles is modulated by alpha-synuclein. J Biol Chem 277:23927-23933
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23927-23933
-
-
Ribeiro, C.S.1
Carneiro, K.2
Ross, C.A.3
Menezes, J.R.4
Engelender, S.5
-
28
-
-
0035003439
-
Chemistry and biochemistry of oxidative stress in neurodegenerative disease
-
Sayre LM, Smith MA, Perry G (2001) Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 8:721-738
-
(2001)
Curr. Med. Chem.
, vol.8
, pp. 721-738
-
-
Sayre, L.M.1
Smith, M.A.2
Perry, G.3
-
29
-
-
0030882856
-
Alpha-Synuclein in Lewy bodies
-
Spillantini MG, Schmidt ML, Lee VM-Y, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-Synuclein in Lewy bodies. Nature 388:839-840
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.-Y.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
30
-
-
0032584686
-
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
-
Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M (1998) Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett 251:205-208
-
(1998)
Neurosci. Lett.
, vol.251
, pp. 205-208
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Cairns, N.J.4
Lantos, P.L.5
Goedert, M.6
-
32
-
-
0035815664
-
Evidence for a partially-folded intermediate in alpha-synuclein fibril formation
-
Uversky VN, Li J, Fink AL (2001) Evidence for a partially-folded intermediate in alpha-synuclein fibril formation. J Biol Chem 276:10737-10744
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10737-10744
-
-
Uversky, V.N.1
Li, J.2
Fink, A.L.3
-
33
-
-
0034085796
-
Synphilin-1 is present in Lewy bodies in Parkinson's disease
-
Wakabayashi K, Engelender S, Yoshimoto M, Tsuji S, Ross CA, Takahashi H (2000) Synphilin-1 is present in Lewy bodies in Parkinson's disease. Ann Neurol 47:521-523
-
(2000)
Ann. Neurol.
, vol.47
, pp. 521-523
-
-
Wakabayashi, K.1
Engelender, S.2
Yoshimoto, M.3
Tsuji, S.4
Ross, C.A.5
Takahashi, H.6
-
34
-
-
0036938071
-
Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders
-
Wakabayashi K, Engelender S, Tanaka Y, Yoshimoto M, Mori F, Tsuji S, Ross CA, Takahashi H (2002) Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders. Acta Neuropathol 103: 209-214
-
(2002)
Acta Neuropathol.
, vol.103
, pp. 209-214
-
-
Wakabayashi, K.1
Engelender, S.2
Tanaka, Y.3
Yoshimoto, M.4
Mori, F.5
Tsuji, S.6
Ross, C.A.7
Takahashi, H.8
-
35
-
-
0033538541
-
Alpha-Synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease
-
Wood SJ, Wypych J, Steavenson S, Louis JC, Citron M, Biere AL (1999) Alpha-Synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. J Biol Chem 274:19509-19512
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 19509-19512
-
-
Wood, S.J.1
Wypych, J.2
Steavenson, S.3
Louis, J.C.4
Citron, M.5
Biere, A.L.6
|