Oligodeoxynucleotide modifications determine the magnitude of B cell stimulation by CpG motifs

Antisense and Nucleic Acid Drug Development

Volumn 6, Issue 2, 1996, Pages 133-139

  Krieg, Arthur M ^a,b   Matson, Sara ^a   Fisher, Eric ^c  

^a UNIVERSITY OF IOWA   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGODEOXYNUCLEOTIDE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; DNA MODIFICATION; DRUG POTENCY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALIA;

EID: 0029811432     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1996.6.133     Document Type: Article

References (4)

1. BEAUCAGE, S.L., and CARUTHERS, M.H. (1981). Deoxynucleoside phosphoramidites - A new class of key intermediates for deoxypolynucleotide synthesis. Tetrahedron Lett. 22, 1859-1862.
2. BROWN, D.A., KANG, S.-H., GRYAZNOV, S.M., DEDIONISIO, L., HEIDENREICH, O., SULLIVAN, S., XU, X., and NERENBERG, M.I. (1994). Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding. J. Biol. Chem. 269, 26801-26805.
3. GAO, W.-Y., HAN, F.S., STORM, C., EGAN, W., and CHENG, Y.-C. (1992). Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology. Mol. Pharmacol. 41, 223-229.
4. ZHAO, Q., WALDSCHMIDT, T., FISHER, E., HERRERA, C.J., and KRIEG, A.M. (1994). Stage-specific oligonucleotide uptake in murine bone marrow B cell precursors. Blood 84, 3660-3666.