Mitochondria in tumor cells studied by laser scanning confocal microscopy

Journal of Biomedical Optics

Volumn 9, Issue 2, 2004, Pages 385-394

  Villa, Anna Maria ^a   Doglia, Silvia Maria ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Carcinoma cells; Confocal fluorescence microscopy; Image analysis; Mitochondria; Mitochondria morphology; Multidrug resistance

Indexed keywords

2 (4 (DIMETHYLAMINO)STYRYL) 1 METHYLPYRIDINIUM; 2-(4-(DIMETHYLAMINO)STYRYL)-1-METHYLPYRIDINIUM; DIAGNOSTIC AGENT; FLUORESCENT DYE; PYRIDINIUM DERIVATIVE; RHODAMINE 123;

ADENOCARCINOMA; ARTICLE; BREAST TUMOR; CARCINOMA; COLON TUMOR; CONFOCAL MICROSCOPY; FEMALE; HUMAN; LUNG TUMOR; MITOCHONDRION; MULTIDRUG RESISTANCE; NEOPLASM; OVARY TUMOR; PATHOPHYSIOLOGY; TUMOR CELL LINE; ULTRASTRUCTURE;

ADENOCARCINOMA; BREAST NEOPLASMS; CARCINOMA; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG RESISTANCE, MULTIPLE; FEMALE; FLUORESCENT DYES; HUMANS; LUNG NEOPLASMS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; NEOPLASMS; OVARIAN NEOPLASMS; PYRIDINIUM COMPOUNDS; RHODAMINE 123;

DRUG PRODUCTS; FLUORESCENCE; IMAGE ANALYSIS; MICROSCOPIC EXAMINATION; PROBES; PROTEINS; TUMORS;

CARCINOMA CELS; DIMETHYLAMINOSTYRYL-METHYLPYRIDINIUMIODINE; DOXORUBICIN; LASER SCANNING CONFOCAL MICROSCOPY; MITOCHONDRIA; MULTIDRUG RESISTANCE; POTENTIOMETRIC PROBES; RHODAMINE;

CELLS;

MINK CELL FOCUS-FORMING VIRUS;

EID: 2442709313     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.1646414     Document Type: Article

References (63)

1. J. A. Endicott and V. Ling, "The biochemistry of P-glycoproteinmediated multidrug resistance", Annu. Rev. Biochem. 58, 137-171 (1989).
2. J. M. Ford and W. N. Hait, "Pharmacology of drugs that alter multidrug resistance in cancer", Pharmacol. Rev. 42, 155-199 (1990). (Pubitemid 20291782)
3. A. K. Larsen, A. E. Escargueil, and A. Skladanowski, "Resistance mechanisms associated with altered intracellular distribution of anticancer agents", Pharmacol. Ther. 85, 217-229 (2000). (Pubitemid 30160791)
4. M. M. Gottesman, T. Fojo, and S. E. Bates, "Multidrug resistance in cancer: role of ATP-dependent transporters", Nat. Rev. Cancer 2, 48-58 (2002). (Pubitemid 37328807)
5. P. D. Roepe, L. Y. Wei, J. Cruz, and D. Carlson, "Lower electrical membrane potential and altered pHi homeostasis in multidrugresistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein", Biochemistry 32, 11042-11056 (1993). (Pubitemid 23332011)
6. S. Simon, D. Roy, and M. Schindler, "Intracellular pH and the control of multidrug resistance", Proc. Natl. Acad. Sci. U. S. A. 91, 1128-1132 (1994). (Pubitemid 24048522)
7. R. Martinez-Zaguilan, N. Raghunand, R. M. Lynch, W. Bellamy, G. M. Martinez, B. Rojas, D. Smith, W. S. Dalton, and R. J. Gillies, "pH and drug resistance. I. Functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines", Biochem. Pharmacol. 57, 1037-1046 (1999). (Pubitemid 29168552)
8. R. L. Juliano and V. Ling, "A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants", Biochim. Biophys. Acta 455, 152-162 (1976).
9. J. H. Gerlach, J. A. Endicott, P. F. Juranka, G. Henderson, F. Sarangi, K. L. Deuchars, and V. Ling, "Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance", Nature (London) 324, 485-489 (1986). (Pubitemid 17184171)
10. K. Ueda, C. Cardarelli, M. M. Gottesman, and I. Pastan, "Expression of a full-length cDNAforthe human 'MDR1' gene confers resistance to colchicine, doxorubicin, and vinblastine", Proc. Natl. Acad. Sci. U. SA. 84, 3004-3008 (1987). (Pubitemid 17064766)
11. P. Borst, R. Evers, M. Kool, and J. Wijnholds, "A family of drug transporters: the multidrug resistance-associated proteins", J. Natl. Cancer Inst. 92, 1295-1302 (2000). (Pubitemid 30662093)
12. D. R. Hipfner, R. J. Deeley, and S. P. C. Cole, "Structural, mechanistic and clinical aspects of MRP1", Biochim. Biophys. Acta 1461, 359-376 (1999).
13. Z. Benderra, A. Trussardi, H. Mojani, A. M. Villa, S. M. Doglia, and M. Manfait, "Regulation of cellular glutathione modulates nuclear accumulation of daunorubicin in human MCF7 cells overexpressing multidrug resistance associated protein", Eur. J. Cancer 36, 428-434 (2000). (Pubitemid 30116741)
14. W. D. Stein, "Kinetics of the multidrug transporter (P-glycoprotein) and its reversal", Physiol. Rev. 77, 545-590 (1997). (Pubitemid 27184348)
15. E. J. F. Demant and E. Friche, "Kinetics of anthracycline accumulation in multidrug-resistant tumor cells: relationship to drug lipophilicity and serum albumin binding", Biochem. Pharmacol. 56, 1209-1217 (1998). (Pubitemid 28511245)
16. D. Kessel, "Exploring multidrug resistance using rhodamine 123", Cancer Commun. 1, 145-149 (1989).
17. S. M. Doglia, L. Bianchi, R. Colombo, N. Allam, H. Morjani, M. Manfait, and A. M. Villa, "Confocal fluorescence microscopy of living cells", 4th International Conference on Laser Applications in life Sciences, Laser Study of Macroscopic Biosystems, Proc. SPIE 1922, 126-134 (1992).
18. J. M. Millot, S. Sharonov, and M. Manfait, "Scanning microspectrofluorometry of rhodamine 123 in multidrug-resistant cells", Cytometry 17, 50-58 (1994).
19. A. M. Villa, "Confocal fluorescence microscopy of living cells", PhD Thesis, Univ. Pierre et Marie Curie, Paris, France (1998).
20. G. Arancia, A. Molinari, A. Calcabrini, G. Citro, A. M. Villa, A. Verdina, and G. Zupi, "Effects of sequential combinations of N-methylformamide with adriamycin on cultured melanoma cells (M14)", Exp. Mol. Pathol. 60, 12-26 (1994). (Pubitemid 24247954)
21. A. Calcabrini, A. M. Villa, A. Molinari, S. M. Doglia, and G. Arancia, "Influence of N-methylformamide on the intracellular transport of doxorubicin", Eur. J. Cell Biol. 72, 61-69 (1997). (Pubitemid 27042708)
22. G. Arancia, A. Calcabrini, S. Meschini, and A. Molinari, "Intracellular distribution of anthracyclines in drug-resistant cells", Cytotechnology 27, 95-111 (1998). (Pubitemid 29025463)
23. T. J. Preston, A. Abadi, L. Wilson, and G. Singh, "Mitochondrial contributions to cancer cell physiology, potential for drug development", Adv. Drug Delivery Rev. 49, 45-61 (2001). (Pubitemid 32493799)
24. L. J. Robinson, W. K. Roberts, T. T. Ling, D. Lamming, S. S. Sternberg, and P. D. Roepe, "Human MDR 1 Protein Overexpression Delays the Apoptotic Cascade in Chinese Hamster Ovary Fibroblasts", Biochemistry 36, 11169-11178 (1997). (Pubitemid 27398436)
25. M. J. Smyth, E. Krasovskis, V. R. Sutton, and R. W. Johnstone, "The drug efflux protein, P-glycoprotein, additionally protects drugresistant tumor cells from multiple forms of caspase-dependent apoptosis", Proc. Natl. Acad. Sci. U. SA. 95, 7024-7029 (1998).
26. R. W. Johnstone, E. Cretney, and M. J. Smyth, "P-glycoprotein protects leukemia cells against caspase-dependent, but not caspaseindependent, cell death", Blood 93, 1075-1085 (1999). (Pubitemid 29067874)
27. P. Costantini, E. Jacotot, D. Decaudin, and G. Kroemer, "Mitochondrion as a novel target of anticancer chemotherapy", J. Natl. Cancer Inst. 92, 1042-1053 (2000). (Pubitemid 30616479)
28. A. D. Schimmer, D. W. Hedley, L. Z. Penn, and D. Minden, "Receptor- and mitochondrial-mediated apoptosis in acute leukemia, a translational view", Blood 98, 3541-3553 (2001).
29. K. Jung and R. Reszka, "Mitochondria as subcellular targets for clinically useful anthracyclines", Adv. Drug Delivery Rev. 49, 87-105 (2001). (Pubitemid 32493802)
30. S. Desagher and J.-C. Martinou, "Mitochondria as the central control of apoptosis", Trends Cell Biol. 10, 369-377 (2000).
31. G. Kroemer and J. C. Reed, "Mitochondrial control of cell death", Nat. Med. 6, 513-519 (2000). (Pubitemid 30305900)
32. V. P. Skulachev, "The programmed death phenomena, aging, and the Samurai law of biology", Exp. Gerontol. 36, 995-1024 (2001). (Pubitemid 32515217)
33. L. V. Johnson, M. L. Walsh, and L. B. Chen, "Localization of mitochondria in living cells with rhodamine 123", Proc. Natl. Acad. Sci. U. SA. 77, 990-994 (1980). (Pubitemid 10105043)
34. L. V. Johnson, M. L. Walsh, B. J. Bockus, and L. B. Chen, "Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy", J. Cell Biol. 88, 526-535 (1981). (Pubitemid 11097944)
35. S. Davis, M. J. Weiss, J. R. Wong, T. J. Lampidis, and L. B. Chen, "Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells", J. Biol. Chem. 260, 13844-13850 (1985). (Pubitemid 16233244)
36. T. Tsuruo, H. Iida, S. Tsukagoshi, and Y. Sakurai, "Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil", Cancer Res. 41, 1967-1972 (1981). (Pubitemid 11114605)
37. T. Tsuruo, H. Iida, M. Nojiri, S. Tsukagoshi, and Y. Sakurai, "Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers", Cancer Res. 43, 2905-2910 (1983). (Pubitemid 13100565)
38. A. Trussardi, G. Poitevin, M. C. Gorisse, M. J. Faroux, H. Bobichon, C. Delvincourt, and J. C. Jardiller, "Sequential overexpression of LRP and MRP but not P-gp 170 in VP16-selected A549 adenocarcinoma cells", Int. J. Oncol. 13, 543-548 (1998).
39. V. P. Skulachev, "Mitochondrial filaments and clusters as intracellular power-transmitting cables", Trends Biochem. Sci. 26, 23-29 (2001). (Pubitemid 32124706)
40. A. Molinari, M. Cianfriglia, S. Meschini, A. Calcabrini, and G. Arancia, "P-glycoprotein expression in the Golgi apparatus of multidrugresistant cells", Int. J. Cancer 59, 789-795 (1994).
41. N. G. Lipsky and R. E. Pagano, "A vital stain for the Golgi apparatus", Science 28, 745-747 (1985).
42. M. Castedo, K. Ferri, T. Roumier, D. Metivier, N. Zamzami, and G. Kroemer, "Quantitation of mitochondrial alterations associated with apoptosis", J. Immunol. Methods 265, 39-47 (2002). (Pubitemid 34628803)
43. J. Frederic, "Recherches Cytologiques sur le chondriome normal ou soumis a l'experimentation dans des cellules vivantes cultivees in vitro", Arch. Biol. (Liege) 69, 167-342 (1958).
44. T. Shimada, K. Horita, M. Murakami, and R. Ogura, "Morphological studies of different mitochondrial populations in monkey myocardial cells", Cell Tissue Res. 238, 577-582 (1984). (Pubitemid 15190661)
45. V. N. Dedov, P. J. Armati, and B. D. Roufogalis, "Three-dimensional organisation of mitochondrial clusters in regenerating dorsal root ganglion (DRG) neurons from neonatal rats: evidence for mobile mitochondrial pools", J. Peripher Nerv. Syst. 5, 3-10 (2000). (Pubitemid 30367273)
46. J. Bereiter-Hahn, "Behavior of mitochondria in the living cell", Int. Rev. Cytol. 122, 1-63 (1990). (Pubitemid 20374368)
47. T. J. Collins, M. J. Berridge, P. Lipp, and M. D. Bootman, "Mitochondria are morphologically and functionally heterogeneous within cells", EMBO J. 21, 1616-1627 (2002). (Pubitemid 34614618)
48. M. R. Duchen, "Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death", J. Physiol. (Lond.) 516, 1-17 (1999). (Pubitemid 29163987)
49. 2+close to IP3-sensitive channels that are sensed by neighboring mitochondria", Science 262, 744-747 (1993). (Pubitemid 23350694)
50. 2+signalling between sarco-endoplasmic reticulum and mitochondria", J. Physiol. (Lond.) 529, 69-81 (2000).
51. G. Csordas, A. P. Thomas, and G. Hajnoczky, "Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria", EMBO J. 18, 96-108 (1999). (Pubitemid 29005027)
52. A. M. Lawrie, R. Rizzuto, T. Pozzan, and A. W. M. Simpson, "A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells", J. Biol. Chem. 271, 10753-10759 (1996). (Pubitemid 26145812)
53. M. K. Park, M. C. Ashby, G. Erdemli, O. H. Petersen, and A. V. Tepikin, "Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport", EMBO J. 20, 1863-1874 (2001). (Pubitemid 32397389)
54. S. Kirischuk, J. Neuhaus, A. Verkhratsky, and H. Kettenmann, "Preferential localization of active mitochondria in process tips of immature retinal oligodendrocytes", NeuroReport 6, 737-741 (1995).
55. R. S. Weinstein, S. M. Jakate, J. M. Dominguez, M. D. Lebovitz, G. K. Koukoulis, J. R. Kuszak, L. F. Klusens, T. M. Grogan, T. J. Saclarides, and I. B. Roninson, "Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis", Cancer Res. 51, 2720-2726 (1991).
56. M. Hojo, T. Morimoto, M. Maluccio, T. Asano, K. Morimoto, M. Lagman, T. Shimbo, and M. Suthanthiran, "Cyclosporine induces cancer progression by a cell-autonomous mechanism", Nature (London) 397, 530-534 (1999).
57. G. Amuthan, G. Biswas, S.-Y. Zhang, A. Klein-Szanto, C. Vijayasarathy, and N. G. Avadhani, "Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion", EMBO J. 20, 1910-1920 (2001). (Pubitemid 32397393)
58. J. E. De Larco, B. R. K. Wuertz, J. C. Manivel, and L. T. Furcht, "Progression and enhancement of metastatic potential after exposure of tumor cells to chemotherapeutic agents", Cancer Res. 61, 2857-2861 (2001). (Pubitemid 32691925)
59. E. F. Farias, J. A. Aguirre Ghiso, V. Ladeda, and E. Bal de Kier Joffe, "Verapamil inhibits tumor protease production, local invasion and metastasis development in murine carcinoma cells", Int. J. Cancer 78, 727-734 (1998). (Pubitemid 28530396)
60. G. J. Randolph, S. Beaulieu, M. Pope, I. Sugawara, L. Hoffman, R. M. Steinman, and W. A. Muller, "A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels", Proc. Natl. Acad. Sci. U. S. A. 95, 6924-6929 (1998). (Pubitemid 28278083)
61. 2+release is inhibited by mitochondrial depolarization", Biochem. J. 347, 593-600 (2000). (Pubitemid 30229409)
62. G. Szalai, R. Krishnamurthy, and G. Hajnoczky, "Apoptosis driven by IP (3)-linked mitochondrial calcium signals", EMBO J. 18, 6349-61 (1999). (Pubitemid 29533239)
63. K. D. Bunting, "ABC transporters as phenotypic markers and functional regulators of stem cells", Stem Cells 20, 11-20 (2002). (Pubitemid 34118906)