Verapamil inhibits tumor protease production, local invasion and metastasis development in murine carcinoma cells

International Journal of Cancer

Volumn 78, Issue 6, 1998, Pages 727-734

  Farías, Eduarde F ^a,c   Aguirre Ghiso, Julio A ^b   Ladeda, Virginia ^a   De Joffé, Elisa Bal Kier ^a,b  

^a Natl Cncl Sci and Technol Res   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c Instituto de Oncologia Angel H Roffo   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; GELATINASE B; PROTEINASE; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM TRANSPORT; CANCER INVASION; DRUG EFFECT; GROWTH INHIBITION; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; LUNG NEOPLASMS; MALE; METALLOENDOPEPTIDASES; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; TUMOR CELLS, CULTURED; URINARY PLASMINOGEN ACTIVATOR; VERAPAMIL;

EID: 3643136387     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19981209)78:6<727::AID-IJC10>3.0.CO;2-A     Document Type: Article

References (29)

1. AGUIRRE GHISO, J.A., ALONSO, D.F., FARÍAS, E.F. and BAL DE KIER JOFFÉ, E. Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D and protein kinase C-dependent pathway in murine mammary adenocarcinoma cells. Biochim. biophys. Acta, 1356, 171-184 (1997).
2. ALONSO, D.F., FARÍAS, E.F. and BAL DE KIER JOFFÉ, E., Urokinase-type plasminogen activator activity released by clonal tumor cell population isolated during the growth of a murine mammary adenocarcinoma. J. exp. clin. Cancer Res., 13, 211-216 (1994).
3. ALONSO, D.F., FARÍAS, E.F., LADEDA, V., DAVEL, L., PURICELLI, L. and BAL DE KIER JOFFÉ, E., Effects of synthetic urokinase inhibitors on focal invasion and metastasis in a murine mammary tumor model. Breast Cancer Res. Treat., 40, 209-223 (1996a).
4. ALONSO, D.C., FARÍAS, E.F., URTREGER, A., LADEDA, V., VIDAL, MC. and BAL DE KIER JOFFÉ, E., Characterization of F3II. a sarcomatoid mammary carcinoma cell line originated from a clonal subpopulation of mouse adenocarcinoma. J. surg. Oncol., 62, 288-297 (1996b).
5. BLOBE, G.C., OBEID, M.L. and HANNUN, Y.A., Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev., 13,411-431 (1994).
6. BONFIL, R.D., MEDINA, P.A., GÓMEZ, D.E., FARÍAS, E.F., LAZAROWSKI, A., LUCERO GRITTI, M.F., MEISS, R.P. and BUSTUOABAD, A., Expression of gelatinase/type IV collagenase in tumor necrosis correlates with cell detachment and tumor invasion. Clin. exp. Metastasi,. 10, 211-220 (1992).
7. BROWN, P.D. and GIAVAZZI, R., Matrix metalloproteinase inhibition: a review of anti-tumor activity. Ann. Oncol., 6, 967-974 (1995).
8. BURGERING, B.M.T. and Boss, J.L., Regulation of Ras-mediated signaling: more than one way to skin a cat. Trends biol. Sci., 20, 18-22 (1995).
9. CHAMBERS, A.F. and MATRISIAN, L.M., Changing views of the role of matrix metalloproteinases in metastasis. J. nat. Cancer Inst., 89, 1260-1270 (1997).
10. CHAMBERS, A.F., SCHMIDT, E.E., MADONALD, I.C., MORRIS, V.L. and GROOM, A.C., Early steps in hematogenous metastasis of B16F1 melanoma cells in chick embryos studied by high-resolution intravital videomicroscopy. J. nat. Cancer Inst., 84, 797-803 (1992).
11. CLAPHAM, D.E., Calcium signaling. Cell, 80, 259-268 (1995).
12. COLE, K. and KOHN, E., Calcium-mediated signal transduction: biology, biochemistry and therapy. Cancer Meiasrasis Rev., 13, 31-44 (1994).
13. FARÍAS, E.F., PURICELLI, L., ALONSO, D.F. and BAL DE KIER JOFFÉ, Metalloproteases in the plasmatic euglobulin fraction of tumor-bearing mice and cancer patients. Proc. Amer. Assoc. Cancer Res., 36, 23 (1995).
14. FARÍAS, E.F., PURICELLI, L., CRESTA, C., PALLOTA, G., ARMANASCO, E., SPECTERMANN, S., SOLARZ, G. and BAL DE KIER JOFFÉ, E., Metalloprotease activity in the plasmatic euglobulin fraction of breast and lung cancer patients. Proc. Amer. Assoc. Cancer Res., 37, 211 (1996).
15. GOODMAN, L.S., OILMAN, A., RALL, T.W., NIES, A.S. and TAYLOR, P., Goodman and Gilman 's pharmacological basis of therapeutics (8th ed.), pp. 756-762, 846-847. Pergamon, Oxford (1990).
16. JAMIS, R.A., SILVER, P.J. and TRIGGLE, D.J., Drug action and cellular calcium regulation. Adv. Drug Res., 16, 309-439 (1987).
17. LAEMMLI, U.K., Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature (Lond.), 227, 680-685 (1970).
18. LAIHO, M. and KESKI-OJA, J., Growth factors in the regulation of pericellular proteolysis: a review. J. Cancer Res., 49, 2533-2553 (1989).
19. LAURICELLA-LEFEBVRE, M.A., CASTRONOVO, V., SATO, H., SETKI, M., FRENCH, D.L. and MERVILLE, M.P., Stimulation of the 92 kD type IV collagenase expression in human melanoma cells. Invasion Metastasis, 13, 289-300 (1993).
20. LIOTTA, L.A. and STETLER-STEVENSON, W.G., Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res., 51, 5054-5059 (1991).
21. MAREEL, M.M., VAN ROY, FM. and DE BAETSELIER, P., The invasive phenotypes. Cancer Metastasis Rev., 9, 45-62 (1990).
22. MOLLER, L.B., Structure and function of urokinase receptor. Blood Coagulation Fibrinolysis, 4, 293-303 (1993).
23. OSSOWSKI, L., Russo-PAYNE, H. and WILSON, E.L., Inhibition of urokinasetype plasminogen activator by antibodies: effect on dissemination of a human tumor in the nude mouse. Cancer Res., 51, 274-281 (1991).
24. REICH, R., BLUMENTHAL, M. and LISCOVITCH, M., Role of phospholipase D in laminin-induced production of gelatinase A (MMP-2) in metastatic cells. Clin. exp. Metastasis, 13, 134-140 (1995).
25. SAKSELA, O., Radial caseinolysis in agarosa: a simple method for detection of plasminogen activator in the presence of inhibitory substances and serum. Ann. Biochem., 111, 276-282 (1981).
26. STETLER-STEVENSON, W.G., LIOTTA, L. and KLEINER, D.J., Jr., Extracellular matrix 6: role of metalloproteinases in tumor invasion and metastasis. FASEB J., 7, 1434-1441 (1993).
27. TSURUO, T., IIDA, H. and TSUKAGOSHI, S., Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res., 41, 1967-1972 (1981).
28. WASILENKO, W. J., PALAD, J., SOMERS. K.D., BLAOCMORE, P.F., KOHN, E., RHIM, J.S., WRIGHT, G.L. and SCHELLHAMMER, P.F., Effects of the calcium influx inhibitor carboxiarmdo-triazole on the proliferation and invasiveness of human prostate tumor cell lines. Int. J. Cancer, 68, 259-264 (1996).
29. YOHEM, K.H., CLOTHIER, J.L., MONTAGUE, S.L., GEARY, R.J., WINTERS, A.L. III. HENDRIX, M.J. and WELCH, D.R., Inhibition of tumor cell invasion by verapamil. Pigment Cell Res., 4, 225-233 (1991).