Exoenzyme Tat-C3 inhibits association of zymosan particles, phagocytosis, adhesion, and complement binding in macrophage cells

Molecules and Cells

Volumn 16, Issue 2, 2003, Pages 216-223

  Park, Jinseu ^a   Kim, Jun Sub ^a   Jung, Kyeong Cheon ^a   Lee, Hak Ju ^a   Kim, Jong Il ^a   Kim, Jaebong ^a   Lee, Jae Yong ^a   Park, Jae Bong ^a   Choi, Soo Young ^a  

^a Hallym University   (South Korea)

Author keywords

Cell adhesion; Complement C3 and C3bi; Integrin; Macrophage; Phagocytosis; Rho; Tat C3 Exoenzyme

Indexed keywords

ADENOSINE DIPHOSPHATE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B; EXOENZYME C3; FIBRINOGEN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ZYMOSAN; BOTULINUM TOXIN; EXOENZYME C3, CLOSTRIDIUM BOTULINUM; INTEGRIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OPSONIN; TRANSACTIVATOR PROTEIN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL ADHESION; COMPLEMENT SYSTEM; CONTROLLED STUDY; ENZYME INHIBITION; GENETIC TRANSFECTION; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; ANIMAL; CELL CULTURE; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR CLONING; PHYSIOLOGY;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1; PHAGO;

ADP RIBOSE TRANSFERASES; ANIMALS; BOTULINUM TOXINS; CELL ADHESION; CELLS, CULTURED; CLONING, MOLECULAR; FIBRINOGEN; GENE PRODUCTS, TAT; INTEGRINS; MACROPHAGES; OPSONIN PROTEINS; PHAGOCYTOSIS; RHOA GTP-BINDING PROTEIN; ZYMOSAN;

EID: 2442691145     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Aderem, A. and Underhill, D. M. (1999) Mechanisms of phagocytosis in macrophages. Ann. Rev. Immunol. 17, 593-623.
2. Aktories, K. and Just, I. (1995) In vitro ADP-ribosylation of Rho by bacterial ADP-ribosyltransferases. Method. Enzymol. 256, 184-195.
3. Aktories, K., Braun, U., Rosener, S., Just, I., and Hall, A. (1989) The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3. Biochem. Biophys. Res. Commun. 158, 209-213.
4. Arnaout, M. A. (1990) Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 15, 1037-1050.
5. Aullo, P., Giry, M., Olsnes, S., Popoff, M. R., Kocks, C., and Boquet, P. (1993) A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly. EMBO J. 12, 921-931.
6. Carlson, S. L., Beiting, D. J., Kiani, C. A., Abell, K. M., and McGillis, J. P. (1996) Catecholamines decrease lymphocyte adhesion to cytokine-activated endothelial cells. Brain Behav. Immun. 10, 55-67.
7. Caron, E. and Hall, A. (1998) Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science 282, 1717-1721.
8. Caron, E., Self, A. J., and Hall, A. (2000) The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators. Curr. Biol. 10, 974-978.
9. Clark, E. A., King, W. G., Brugge, J. S., Symons, M., and Hynes, R. O. (1998) Integrin-mediated signals regulated by members of the rho family of GTPases. J. Cell Biol. 142, 573-586.
10. Derossi, D., Joliot, A. H., Chassaing, G., and Prochiantz, A. (1994) The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem. 269, 10444-10450.
11. Derossi, D., Calvet, S., Trembleau, A., Brunissen, A., Chassaing, G., and Prochiantz, A. (1996) Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent. J. Biol. Chem. 271, 18188-18193.
12. Eum, W. S., Choung, I. S., Kim, J. A., Lee, Y. J., Kang, J. H., Park, J., Lee, K. S., Kwon, H. Y., and Choi, S. Y. (2002) Transduction efficacy of HIV-1 Tat-superoxide dismutase is enhanced by copper ion recovery of the fusion protein. Mol. Cells 13, 334-340.
13. Fawell, S., Seery, J., Daikh, Y., Moore, C., Chen, L. L., Pepinsky, B., and Barsoum, J. (1994) Tat-mediated delivery of heterologous proteins into cells. Proc. Natl. Acad. Sci. USA 91, 664-668.
14. Gelfand, J. A., Fauci, A. S., Green, I., and Frank, M. M. (1976) A simple method for the determination of complement receptor-bearing mononuclear cells. J. Immunol. 116, 595-599.
15. Hed, J. and Stendahl, O. (1982) Differences in the ingestion mechanisms of IgG and C3b particles in phagocytosis by neutrophils. Immunology 45, 727-736.
16. Hed, J., Hallden, G., Johansson, S. G., and Larsson, P. (1987) The use of fluorescence quenching in flow cytofluorimetry to measure the attachment and ingestion phases in phagocytosis in peripheral blood without prior cell separation. J. Immunol. Methods 101, 119-125.
17. Hughes, P. E. and Pfaff, M. (1998) Integrin affinity modulation. Trends Cell Biol. 8, 359-364.
18. Jin, L. H., Eum, W. S., Kwon, H. Y., Bahn, J. H., Jang, S. H., Han, K. H., Kang, T. C., Won, M. H., Kang, J. H., Cho, S. W., Park, J., and Choi, S. Y. (2001) Tansduction of human catalase mediated by an HIV-1 Tat protein basic domain and arginine rich peptides into mammalian cells. Free Radical Biol. Med. 31, 1509-1519.
19. Kwon, H. Y., Eum, W. S., Jang, H. W., Kang, J. H., Ryu, J. Y., Lee, R. B., Jin, L. H., Park, J., and Choi, S. Y. (2000) Transduction of Cu,Zn-superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells. FEBS Lett. 485, 163-167.
20. Laudanna, C., Campbell, J. J., and Butcher, E. C. (1996) Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science 271, 981-983.
21. Leng, L., Kashiwagi, H., Ren, X. D., and Shattil, S. J. (1998) RhoA and the function of platelet integrin alphaIIbbeta3. Blood 91, 4206-4215.
22. Massol, P., Montcourrier, P., Guillemot, J. C., and Chavrier, P. (1998) Fc receptor-mediated phagocytosis requires CDC42 and Rac1. EMBO J. 17, 6219-6229.
23. Mauro, A., Germano, I., Giaccone, G., Giordana, M. T., and Schiffer, D. (1985) 1-Naphthol basic dye (1-NBD). An alternative to diaminobenzidine (DAB) in immunoperoxidase techniques. Histochemistry 83, 97-102.
24. Nagahara, H., Vocero-Akbani, A. M., Snyder, E. L., Ho, A., Latham, D. G., Lissy, N. A., Becker-Hapak, M., Ezhevsky, S. A., and Dowdy, S. F. (1998) Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat. Med. 4, 1449-1452.
25. Olson, M. F., Paterson, H. F., and Marshall, C. J. (1998) Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 394, 295-299.
26. Park, J., Kim, K. A., Ryu, J. Y., Choi, E. Y., Lee, K. S., and Choi, S. Y. (2000) Generation and characterization of cell-permeable green fluorescent protein mediated by the basic domain of human immunodeficiency virus type 1 Tat. J. Microbiol. Biotechnol. 10, 797-804.
27. Park, J., Ryu, J., Jin, L. H., Bahn, J. H., Kim, J. A., Yoon, C. S., Kim, D. W., Han, K. H., Eum, W. S., Kwon, H. Y., Kang, T. C., Won, M. H., Kang, J. H., Cho, S. W., and Choi, S. Y. (2002a) 9-Polylysine protein transduction domain: enhanced penetration efficiency of superoxide dismutase into mammalian cells and skin. Mol. Cells 13, 202-208.
28. Park, J., Ryu, J., Kim, K. A., Lee, H. J., Bahn, J. H., Han, K. H., Choi, E. Y., Lee, K. S., Kwon, H. Y., and Choi, S. Y. (2002b) Mutational analysis of a human immunodeficiency virus type I Tat protein transduction domain which is required for delivery of an exogenous protein into mammalian cells. J. Gen. Virol. 83, 1173-1181.
29. Plow, E. F., Hass, T. A., Zhang, L., Loftus, J., and Smith, J. W. (2000) Ligand binding to integrins. J. Biol. Chem. 275, 21785-21788.
30. Rodriguez-Fernandez, J. L., Sanchez-Martin, L., Rey, M., Vicente-Manzanares, M., Narumiya, S., Teixido, J., Sanchez-Madrid, F., and Cabanas, C. (2001) Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1. J. Biol. Chem. 276, 40518-40527.
31. Sambrook, J., Fritsch, F. E., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
32. Sauzeau, V., Le Mellionnec, E., Bertoglio, J., Scalbert, E., Pacaud, P., and Loirand, G. (2001) Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase. Circ. Res. 88, 1102-1104.
33. Schoenwaelder, S. M. and Burridge, K. (1999) Bidirectional signaling between the cytoskeleton and integrins. Curr. Opin. Cell Biol. 11, 274-286.
34. Schwartz, M. A. and Shattil, S. J. (2000) Signaling networks linking integrins and rho family GTPases. Trends Biochem. Sci. 25, 388-391.
35. Schwarze, S. R., Ho, A., Vocero-Akbani, A., and Dowdy, S. F. (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285, 1569-1572.
36. Ueda, T., Rieu, P., Brayer, J., and Arnaout, M. A. (1994) Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CDIIb/CD18). Proc. Natl. Acad. Sci. USA 91, 10680-10684.
37. Van Aelst, L. and D'Souza-schorey, C. (1997) Rho GTPases and signaling networks. Genses Dev. 11, 2295-2322.
38. Vocero-Akbani, A., Heyden, N. A., Lissy, N. A., Ratner, L., and Dowdy, S. F. (1999) Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein. Nat. Med. 5, 29-33.
39. Wiegers, W., Just, I., Muller, H., Hellwig, A., Traub, P., and Aktories, K. (1991) Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase. Eur. J. Cell Biol. 54, 237-245.
40. Wright, S. D., Rao, P. E., van Voorhis, W. C., Craigmyle, L. S., Iida, K., Talle, M. A., Westberg, E. F., Goldstein, G., and Silverstein, S. C. (1983) Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies. Proc. Natl. Acad. Sci. USA 80, 5699-5703.
41. Yoon, H. Y., Lee, S. H., Cho, S. W., Lee, J. E., Yoon, C. S., Park, J., Kim, T. U., and Choi, S. Y. (2002) Tat-mediated delivery of human glutamate dehydrogenase into PC 12 cells. Neurochem. Int. 41, 37-42.
42. Zhang, L. and Plow, E. F. (1999) Amino acid sequences within the alpha subunit of integrin alpha M beta 2 (Mac-1) critical for specific recognition of C3bi. Biochemistry 38, 8064-8071.