-
1
-
-
0031890960
-
Marginal fitness contributions of nonessential genes in yeast
-
Thatcher,J.W., Shaw,J.M. and Dickinson,W.J. (1998) Marginal fitness contributions of nonessential genes in yeast. Proc. Natl Acad. Sci. USA, 95, 253-257.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 253-257
-
-
Thatcher, J.W.1
Shaw, J.M.2
Dickinson, W.J.3
-
2
-
-
0036699060
-
Systematic screen for human disease genes in yeast
-
Steinmetz,L.M., Scharfe,C., Deutschbauer,A.M., Mokranjac,D., Herman,Z.S., Jones,T., Chu,A.M., Giaever,G., Prokisch,H., Oefner,P.J. and Davis,R.W. (2002) Systematic screen for human disease genes in yeast. Nature Genet., 31, 400-404.
-
(2002)
Nature Genet.
, vol.31
, pp. 400-404
-
-
Steinmetz, L.M.1
Scharfe, C.2
Deutschbauer, A.M.3
Mokranjac, D.4
Herman, Z.S.5
Jones, T.6
Chu, A.M.7
Giaever, G.8
Prokisch, H.9
Oefner, P.J.10
Davis, R.W.11
-
3
-
-
0347033256
-
Role of duplicate genes in genetic robustness against null mutations
-
Gu,Z.L., Steinmetz,L.M., Gu,X., Scharfe,C., Davis,R.W. and Li,W.-H. (2003) Role of duplicate genes in genetic robustness against null mutations. Nature, 421, 63-66.
-
(2003)
Nature
, vol.421
, pp. 63-66
-
-
Gu, Z.L.1
Steinmetz, L.M.2
Gu, X.3
Scharfe, C.4
Davis, R.W.5
Li, W.-H.6
-
4
-
-
1542298437
-
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions
-
Simmer,F., Moorman,C., van der Linden,A.M., Kuijk,E., van den Berghe,P.V.E., Kamath,R.S., Fraser,A.G., Ahringer,J. and Plasterk,R.H.A. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol., 1, 77-84.
-
(2003)
PLoS Biol.
, vol.1
, pp. 77-84
-
-
Simmer, F.1
Moorman, C.2
van der Linden, A.M.3
Kuijk, E.4
van den Berghe, P.V.E.5
Kamath, R.S.6
Fraser, A.G.7
Ahringer, J.8
Plasterk, R.H.A.9
-
5
-
-
15444356255
-
Lethal mutations defining 112 complementation groups in a 4.5 Mb sequenced region of Caenorhabditis elegans chromosome III
-
Stewart,H.I., O'Neil,N.J., Janke,D.L., Franz,N.W., Chamberlin,H.M., Howell,A.M., Gilchrist,E.J., Ha,T.T., Kuervers,L.M., Vatcher,G.P., Danielson,J.L. and Baillie,D.L. (1998) Lethal mutations defining 112 complementation groups in a 4.5 Mb sequenced region of Caenorhabditis elegans chromosome III. Mol. Gen. Genet., 260, 280-288.
-
(1998)
Mol. Gen. Genet.
, vol.260
, pp. 280-288
-
-
Stewart, H.I.1
O'Neil, N.J.2
Janke, D.L.3
Franz, N.W.4
Chamberlin, H.M.5
Howell, A.M.6
Gilchrist, E.J.7
Ha, T.T.8
Kuervers, L.M.9
Vatcher, G.P.10
Danielson, J.L.11
Baillie, D.L.12
-
6
-
-
0033797401
-
Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans
-
Johnsen,R.C., Jones,S.J.M. and Rose,A.M. (2000) Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Mol. Gen. Genet., 263, 239-252.
-
(2000)
Mol. Gen. Genet.
, vol.263
, pp. 239-252
-
-
Johnsen, R.C.1
Jones, S.J.M.2
Rose, A.M.3
-
7
-
-
0037274701
-
A P-element insertion screen identified mutations in 455 novel essential genes in Drosophila
-
Oh,S.W., Kingsley,T., Shin,H., Zheng,Z.Y., Chen,H.W., Chen,X., Wang,H., Ruan,P.Z., Moody,M. and Hou,SX (2003) A P-element insertion screen identified mutations in 455 novel essential genes in Drosophila. Genetics, 163, 195-201.
-
(2003)
Genetics
, vol.163
, pp. 195-201
-
-
Oh, S.W.1
Kingsley, T.2
Shin, H.3
Zheng, Z.Y.4
Chen, H.W.5
Chen, X.6
Wang, H.7
Ruan, P.Z.8
Moody, M.9
Hou, S.X.10
-
8
-
-
12644268233
-
A genetic screen for mutations affecting embryogenesis in zebrafish
-
Driever,W., Solnica-Krezel,L., Schier,A.F., Neuhauss,S.C.F., Malicki,J., Stemple,D.L., Stainier,D.Y.R., Zwartkruis,F., Abdelilah,S., Rangini,Z., Belak,J. and Boggs,C. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development, 123, 37-46.
-
(1996)
Development
, vol.123
, pp. 37-46
-
-
Driever, W.1
Solnica-Krezel, L.2
Schier, A.F.3
Neuhauss, S.C.F.4
Malicki, J.5
Stemple, D.L.6
Stainier, D.Y.R.7
Zwartkruis, F.8
Abdelilah, S.9
Rangini, Z.10
Belak, J.11
Boggs, C.12
-
9
-
-
12644303221
-
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
-
Haffter,P., Granato,M., Brand,M., Mullins,M.C., Hammerschmidt,M., Kane,D.A., Odenthal,J., van Eeden,F.J.M., Jiang,Y.J., Heisenberg,C.P., Kelsh,R.N., Furutani-Seiki,M., Vogelsang,E., Beuchle,D., Schach,U., Fabian,C. and Nusslein-Volhard,C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development, 123, 1-36.
-
(1996)
Development
, vol.123
, pp. 1-36
-
-
Haffter, P.1
Granato, M.2
Brand, M.3
Mullins, M.C.4
Hammerschmidt, M.5
Kane, D.A.6
Odenthal, J.7
van Eeden, F.J.M.8
Jiang, Y.J.9
Heisenberg, C.P.10
Kelsh, R.N.11
Furutani-Seiki, M.12
Vogelsang, E.13
Beuchle, D.14
Schach, U.15
Fabian, C.16
Nusslein-Volhard, C.17
-
10
-
-
0022600899
-
Induction of recessive lethal mutations in the t/t-h-2 region of the mouse genome by a point mutagen
-
Shedlovsky,A., Guenet,J.L., Johnson,L.L. and Dove,W.F. (1986) Induction of recessive lethal mutations in the t/t-h-2 region of the mouse genome by a point mutagen. Genet. Res., 47, 135-142.
-
(1986)
Genet. Res.
, vol.47
, pp. 135-142
-
-
Shedlovsky, A.1
Guenet, J.L.2
Johnson, L.L.3
Dove, W.F.4
-
11
-
-
0035775227
-
ENU mutagenesis: Analyzing gene function in mice
-
Balling,R. (2001) ENU mutagenesis: analyzing gene function in mice. Annu. Rev. Genomics Hum. Genet., 2, 463-492.
-
(2001)
Annu. Rev. Genomics Hum. Genet.
, vol.2
, pp. 463-492
-
-
Balling, R.1
-
12
-
-
0036983822
-
Lipoprotein lipase deficiency - Rare or common?
-
Evans,V. and Kastelein,J.J. (2002) Lipoprotein lipase deficiency - rare or common? Cardiovasc. Drugs Ther., 16, 283-287.
-
(2002)
Cardiovasc. Drugs Ther.
, vol.16
, pp. 283-287
-
-
Evans, V.1
Kastelein, J.J.2
-
13
-
-
18444362122
-
Biallelic inactivation of BRCA2 in Fanconi anemia
-
Howlett,N.G, Taniguchi,T., Olson,S., Cox,B., Waisfisz,Q., De Die-Smulders,C., Persky,N., Grompe,M., Joenje,H., Pals,G., Ikeda,H., Fox,E.A. and D'Andrea,A.D. (2002) Biallelic inactivation of BRCA2 in Fanconi anemia. Science, 297, 606-609.
-
(2002)
Science
, vol.297
, pp. 606-609
-
-
Howlett, N.G.1
Taniguchi, T.2
Olson, S.3
Cox, B.4
Waisfisz, Q.5
De Die-Smulders, C.6
Persky, N.7
Grompe, M.8
Joenje, H.9
Pals, G.10
Ikeda, H.11
Fox, E.A.12
D'Andrea, A.D.13
-
15
-
-
0037267313
-
Knockouts model the 100 best-selling drugs - Will they model the next 100?
-
Zambrowicz,B.P. and Sands,A.T. (2003) Knockouts model the 100 best-selling drugs - will they model the next 100? Nature Rev. Drug Discov., 2, 38-51.
-
(2003)
Nature Rev. Drug Discov.
, vol.2
, pp. 38-51
-
-
Zambrowicz, B.P.1
Sands, A.T.2
-
16
-
-
0036894289
-
Challenges and strategies for investigating the genetic complexity of common human diseases
-
Rich,S.S. and Concannon,P. (2002) Challenges and strategies for investigating the genetic complexity of common human diseases. Diabetes, 51 (suppl. 3), S288-S294.
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 3
-
-
Rich, S.S.1
Concannon, P.2
-
17
-
-
0036676656
-
An update on genetic studies of systemic lupus erythematosus
-
Tsao,B.P. (2002) An update on genetic studies of systemic lupus erythematosus. Curr. Rheumatol. Rep., 4, 359-367.
-
(2002)
Curr. Rheumatol. Rep.
, vol.4
, pp. 359-367
-
-
Tsao, B.P.1
-
18
-
-
0037866676
-
Nonsyndromic X-linked mental retardation: Where are the missing mutations?
-
Ropers,H.-H., Hoeltzenbein,M., Kalscheuer,V., Yntema,H., Hamel,B., Fryns,J.-P., Chelly,J., Partington,M., Gecz,J. and Moraine,C. (2003) Nonsyndromic X-linked mental retardation: where are the missing mutations? Trends Genet., 19, 316-320.
-
(2003)
Trends Genet.
, vol.19
, pp. 316-320
-
-
Ropers, H.-H.1
Hoeltzenbein, M.2
Kalscheuer, V.3
Yntema, H.4
Hamel, B.5
Fryns, J.-P.6
Chelly, J.7
Partington, M.8
Gecz, J.9
Moraine, C.10
-
19
-
-
0038537569
-
Prostate cancer susceptibility genes: Lessons learned and challenges posed
-
Simard,J., Dumont,M., Labuda,D., Sinnett,D., Meloche,C., El-Alfy,M., Berger,L., Lees,E., Labrie,F. and Tavtigian,S.V. (2003) Prostate cancer susceptibility genes: lessons learned and challenges posed. Endocr. Relat. Cancer, 10, 225-259.
-
(2003)
Endocr. Relat. Cancer
, vol.10
, pp. 225-259
-
-
Simard, J.1
Dumont, M.2
Labuda, D.3
Sinnett, D.4
Meloche, C.5
El-Alfy, M.6
Berger, L.7
Lees, E.8
Labrie, F.9
Tavtigian, S.V.10
-
20
-
-
0346274979
-
New methods for finding disease-susceptibility genes: Impact and potential
-
research
-
McCarthy,M.I., Smedley,D. and Hide,W. (2003) New methods for finding disease-susceptibility genes: impact and potential. Genome Biol., 4, research 119.
-
(2003)
Genome Biol.
, vol.4
, pp. 119
-
-
McCarthy, M.I.1
Smedley, D.2
Hide, W.3
-
21
-
-
0031663782
-
Position effect in human genetic disease
-
Kleinjan,D.J. and van Heyningen,V. (1998) Position effect in human genetic disease. Hum. Mol. Genet., 7, 1611-1618.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1611-1618
-
-
Kleinjan, D.J.1
van Heyningen, V.2
-
22
-
-
0017323923
-
Biochemical evolution
-
Wilson,A.C., Carlson,S.S. and White,T.J. (1977) Biochemical evolution. Annu. Rev. Biochem., 46, 573-639.
-
(1977)
Annu. Rev. Biochem.
, vol.46
, pp. 573-639
-
-
Wilson, A.C.1
Carlson, S.S.2
White, T.J.3
-
23
-
-
0038708556
-
Rate of protein evolution versus fitness effect of gene deletion
-
Yang,J., Gu,Z.L. and Li,W.-H. (2003) Rate of protein evolution versus fitness effect of gene deletion. Mol. Biol. Evol., 20, 772-774,
-
(2003)
Mol. Biol. Evol.
, vol.20
, pp. 772-774
-
-
Yang, J.1
Gu, Z.L.2
Li, W.-H.3
-
24
-
-
0035963414
-
Protein dispensability and rate of evolution
-
Hirsh,A.E. and Fraser,H.B. (2001) Protein dispensability and rate of evolution. Nature, 411, 1046-1049.
-
(2001)
Nature
, vol.411
, pp. 1046-1049
-
-
Hirsh, A.E.1
Fraser, H.B.2
-
25
-
-
0036078078
-
Essential genes are more evolutionarily conserved than are nonessential genes in bacteria
-
Jordan,I.K., Rogozin,I.B., Wolf,Y.I. and Koonin,E.V. (2002) Essential genes are more evolutionarily conserved than are nonessential genes in bacteria. Genome Res., 12, 962-968.
-
(2002)
Genome Res.
, vol.12
, pp. 962-968
-
-
Jordan, I.K.1
Rogozin, I.B.2
Wolf, Y.I.3
Koonin, E.V.4
-
26
-
-
84984769114
-
Genomic function (communication arising): Rate of evolution and gene dispensability
-
Hirsh,A.E. and Fraser,H.B. (2003) Genomic function (communication arising): rate of evolution and gene dispensability. Nature, 421, 497-498.
-
(2003)
Nature
, vol.421
, pp. 497-498
-
-
Hirsh, A.E.1
Fraser, H.B.2
-
27
-
-
0033565762
-
Do essential genes evolve slowly?
-
Hurst,L.D. and Smith,N.G.C. (1999) Do essential genes evolve slowly? Curr. Biol., 9, 747-750.
-
(1999)
Curr. Biol.
, vol.9
, pp. 747-750
-
-
Hurst, L.D.1
Smith, N.G.C.2
-
28
-
-
0037472928
-
Rate of evolution and gene dispensability
-
Pal,C., Papp,B. and Hurst,L.D. (2003) Rate of evolution and gene dispensability. Nature, 421, 496-497.
-
(2003)
Nature
, vol.421
, pp. 496-497
-
-
Pal, C.1
Papp, B.2
Hurst, L.D.3
-
29
-
-
1242284655
-
An analysis of determinants of amino acids substitution rates in bacterial proteins
-
Rocha,E.P.C. and Danchin,A. (2004) An analysis of determinants of amino acids substitution rates in bacterial proteins. Mol. Biol. Evol., 21, 108-116.
-
(2004)
Mol. Biol. Evol.
, vol.21
, pp. 108-116
-
-
Rocha, E.P.C.1
Danchin, A.2
-
30
-
-
0142124263
-
Gene loss, protein sequence divergence, gene dispensability, expression level and interactivity are correlated in eukaryotic evolution
-
Krylov,D.M., Wolf,Y.I., Rogozin,I.B. and Koonin,E.V. (2003) Gene loss, protein sequence divergence, gene dispensability, expression level and interactivity are correlated in eukaryotic evolution. Genome Res., 13, 2229-2235.
-
(2003)
Genome Res.
, vol.13
, pp. 2229-2235
-
-
Krylov, D.M.1
Wolf, Y.I.2
Rogozin, I.B.3
Koonin, E.V.4
-
31
-
-
0242285634
-
Human disease genes: Patterns and predictions
-
Smith,N.G.C. and Eyre-Walker,A. (2003) Human disease genes: patterns and predictions. Gene, 318, 169-175..
-
(2003)
Gene
, vol.318
, pp. 169-175
-
-
Smith, N.G.C.1
Eyre-Walker, A.2
-
32
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
International Human Genome Sequencing Consortium
-
International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature, 409, 860-921.
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
-
33
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul,S.F., Madden,T.L., Schäffer,A.A., Zhang,J., Zhang,Z., Miller,W. and Lipman,D.J. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res., 25, 3389-3402.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schäffer, A.A.3
Zhang, J.4
Zhang, Z.5
Miller, W.6
Lipman, D.J.7
-
34
-
-
0037252705
-
Database resources of the National Center for Biotechnology
-
Wheeler,D.L., Church,D.M., Federhen,S., Lash,A.E., Madden,T.L., Pontius,J.U., Schuler,G.D., Schriml,L.M., Sequeira,E., Tatusova,T.A. and Wagner,L. (2003) Database resources of the National Center for Biotechnology. Nucleic Acids Res., 31, 28-33.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 28-33
-
-
Wheeler, D.L.1
Church, D.M.2
Federhen, S.3
Lash, A.E.4
Madden, T.L.5
Pontius, J.U.6
Schuler, G.D.7
Schriml, L.M.8
Sequeira, E.9
Tatusova, T.A.10
Wagner, L.11
-
35
-
-
1542563409
-
Initial sequencing and comparative analysis of the mouse genome
-
Mouse Genome Sequencing Consortium
-
Mouse Genome Sequencing Consortium (2002) Initial sequencing and comparative analysis of the mouse genome. Nature, 420, 520-562.
-
(2002)
Nature
, vol.420
, pp. 520-562
-
-
-
36
-
-
0024234855
-
CLUSTAL - A package for performing multiple sequence alignment on a microcomputer
-
Higgins,D.G. and Sharp,P.M. (1988) CLUSTAL - a package for performing multiple sequence alignment on a microcomputer. Gene, 73, 237-244.
-
(1988)
Gene
, vol.73
, pp. 237-244
-
-
Higgins, D.G.1
Sharp, P.M.2
-
37
-
-
0030683599
-
PAML: A program package for phylogenetic analysis by maximum likelihood
-
Yang,Z.H. (1997) PAML: a program package for phylogenetic analysis by maximum likelihood. Comput. Appl. Biosci., 13, 555-556.
-
(1997)
Comput. Appl. Biosci.
, vol.13
, pp. 555-556
-
-
Yang, Z.H.1
-
38
-
-
0037249406
-
The FlyBase database of the Drosophila genome projects and community literature
-
Gelbart,W., Bayraktaroglu,L., Bettencourt,B., Campbell,K., Crosby,M., Emmert,D., Hradecky,P., Huang,Y., Letovsky,S., Matthews,B., Russo,S., Schroeder,A., Smutniak,F., Zhou,P., Zytkovicz,M., Ashburner,M., Drysdale,R., de Grey,A., Foulger,R., Millburn,G., Yamada,C., Kaufman,T., Matthews,K., Gilbert,D., Grumbling,G., Strelets,V., Shemen,C., Rubin,G., Berman,B., Frise,E., Gibson,M., Harris,N., Kaminker,J., Lewis,S., Marshall,B., Misra,S., Mungall,C., Prochnik,S., Richter,J., Smith,C., Shu,S., Tupy,J. and Wiel,C. (2003) The FlyBase database of the Drosophila genome projects and community literature. Nucleic Acids Res., 31, 172-175.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 172-175
-
-
Gelbart, W.1
Bayraktaroglu, L.2
Bettencourt, B.3
Campbell, K.4
Crosby, M.5
Emmert, D.6
Hradecky, P.7
Huang, Y.8
Letovsky, S.9
Matthews, B.10
Russo, S.11
Schroeder, A.12
Smutniak, F.13
Zhou, P.14
Zytkovicz, M.15
Ashburner, M.16
Drysdale, R.17
de Grey, A.18
Foulger, R.19
Millburn, G.20
Yamada, C.21
Kaufman, T.22
Matthews, K.23
Gilbert, D.24
Grumbling, G.25
Strelets, V.26
Shemen, C.27
Rubin, G.28
Berman, B.29
Frise, E.30
Gibson, M.31
Harris, N.32
Kaminker, J.33
Lewis, S.34
Marshall, B.35
Misra, S.36
Mungall, C.37
Prochnik, S.38
Richter, J.39
Smith, C.40
Shu, S.41
Tupy, J.42
Wiel, C.43
more..
-
39
-
-
0036699596
-
Selection for short introns in highly expressed genes
-
Castillo-Davis,C.I., Mekhedov,S.L., Hartl,D.L., Koonin,E.V. and Kondrashov,F.A. (2002) Selection for short introns in highly expressed genes. Nature Genet., 31, 415-418.
-
(2002)
Nature Genet.
, vol.31
, pp. 415-418
-
-
Castillo-Davis, C.I.1
Mekhedov, S.L.2
Hartl, D.L.3
Koonin, E.V.4
Kondrashov, F.A.5
-
40
-
-
0001468848
-
Splicing of precursors to mRNAs by the spliceosomes
-
Gesteland,R.F., Cech,T.R. and Atkins,J.F. (eds), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
-
Burge,C.B., Tuschl,T. and Sharp,P.A. (1999) Splicing of precursors to mRNAs by the spliceosomes. In Gesteland,R.F., Cech,T.R. and Atkins,J.F. (eds), The RNA World. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 525-560.
-
(1999)
The RNA World
, pp. 525-560
-
-
Burge, C.B.1
Tuschl, T.2
Sharp, P.A.3
-
41
-
-
0033233944
-
A glossary of basic neural network terminology for regression problems
-
Stegemann,J.A. and Buenfeld,N.R. (1999) A glossary of basic neural network terminology for regression problems. Neural Comput. Appl., 84, 290-296.
-
(1999)
Neural Comput. Appl.
, vol.84
, pp. 290-296
-
-
Stegemann, J.A.1
Buenfeld, N.R.2
-
44
-
-
4243088097
-
The genome sequence of Caenorhabditis briggsae: A platform for comparative genomics
-
Stein,L.D., Bao,Z., Blasiar,D., Blumenthal,T., Brent,M.R., Chen,N., Chinwalla,A., Clarke,L., Clee,C., Coghlan,A. et al. (2003) The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol., 1, 166-192.
-
(2003)
PLoS Biol.
, vol.1
, pp. 166-192
-
-
Stein, L.D.1
Bao, Z.2
Blasiar, D.3
Blumenthal, T.4
Brent, M.R.5
Chen, N.6
Chinwalla, A.7
Clarke, L.8
Clee, C.9
Coghlan, A.10
|