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Volumn 51, Issue SUPPL. 3, 2002, Pages

Challenges and strategies for investigating the genetic complexity of common human diseases

Author keywords

[No Author keywords available]

Indexed keywords

CONFERENCE PAPER; ENVIRONMENTAL FACTOR; GENE IDENTIFICATION; GENE INTERACTION; GENE LOCUS; GENE MAPPING; GENETIC SUSCEPTIBILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR GENETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0036894289     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.2007.s288     Document Type: Conference Paper
Times cited : (33)

References (46)
  • 1
    • 0024204046 scopus 로고
    • Trends in the prevalence and incidence of diabetes: Insulin-dependent diabetes mellitus in childhood
    • Rewers M, LaPorte RE, King H, Tuomilehto J: Trends in the prevalence and incidence of diabetes: Insulin-dependent diabetes mellitus in childhood. World Health Stat Q 41:179-189, 1988
    • (1988) World Health Stat Q , vol.41 , pp. 179-189
    • Rewers, M.1    LaPorte, R.E.2    King, H.3    Tuomilehto, J.4
  • 2
    • 0025951555 scopus 로고
    • The changing face of the epidemiology of insulin-dependent diabetes mellitus (IDDM): Research designs and models of disease causation
    • Rewers MJ: The changing face of the epidemiology of insulin-dependent diabetes mellitus (IDDM): Research designs and models of disease causation. Ann Med 23:419-426, 1991
    • (1991) Ann Med , vol.23 , pp. 419-426
    • Rewers, M.J.1
  • 3
    • 0027215080 scopus 로고
    • How many people in the U.S. have IDDM?
    • Libman I, Songer T, LaPorte R: How many people in the U.S. have IDDM? Diabetes Care 16:841-842, 1993
    • (1993) Diabetes Care , vol.16 , pp. 841-842
    • Libman, I.1    Songer, T.2    LaPorte, R.3
  • 4
    • 0025094344 scopus 로고
    • Mapping genes in diabetes: A genetic epidemiological perspective
    • Rich SS: Mapping genes in diabetes: A genetic epidemiological perspective. Diabetes 39:1315-1319, 1990
    • (1990) Diabetes , vol.39 , pp. 1315-1319
    • Rich, S.S.1
  • 7
    • 0026641354 scopus 로고
    • Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
    • Kaprio J, Tumiletho J, Koskenvuo M, Romanov K, Renuanen A, Erikson J, Stengaard J, Kesaaniemi YA: Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 35:1060-1067, 1992
    • (1992) Diabetologia , vol.35 , pp. 1060-1067
    • Kaprio, J.1    Tumiletho, J.2    Koskenvuo, M.3    Romanov, K.4    Renuanen, A.5    Erikson, J.6    Stengaard, J.7    Kesaaniemi, Y.A.8
  • 8
    • 0027169651 scopus 로고
    • North-American twins with IDDM: Genetic, etiological, and clinical significance of disease concordance according to age, zygosity, and the interval after diagnosis in first twin
    • Kumar D, Gemayel NS, Deapen D, Kapadia D, Yamashita PH, Lee M, Dwyer JH, Roy-Burman P, Bray GA, Mack TM: North-American twins with IDDM: Genetic, etiological, and clinical significance of disease concordance according to age, zygosity, and the interval after diagnosis in first twin. Diabetes 42:1351-1363, 1993
    • (1993) Diabetes , vol.42 , pp. 1351-1363
    • Kumar, D.1    Gemayel, N.S.2    Deapen, D.3    Kapadia, D.4    Yamashita, P.H.5    Lee, M.6    Dwyer, J.H.7    Roy-Burman, P.8    Bray, G.A.9    Mack, T.M.10
  • 9
    • 0018147206 scopus 로고
    • Diabetes mellitus among first- and second-degree relatives of early diabetics
    • Degnbol B, Green A: Diabetes mellitus among first- and second-degree relatives of early diabetics. Ann Hum Genet 42:25-47, 1978
    • (1978) Ann Hum Genet , vol.42 , pp. 25-47
    • Degnbol, B.1    Green, A.2
  • 10
    • 0019849990 scopus 로고
    • The modes of inheritance of insulin-dependent diabetes mellitus or the genetics of IDDM, no longer a nightmare but still a headache
    • Rotter JI: The modes of inheritance of insulin-dependent diabetes mellitus or the genetics of IDDM, no longer a nightmare but still a headache. Am J Hum Genet 33:835-851, 1981
    • (1981) Am J Hum Genet , vol.33 , pp. 835-851
    • Rotter, J.I.1
  • 11
    • 0023550313 scopus 로고
    • Age-corrected empirical genetic risk estimates for first-degree relatives of IDDM patients
    • Tillil H, Kobberling J: Age-corrected empirical genetic risk estimates for first-degree relatives of IDDM patients. Diabetes 36:93-99, 1987
    • (1987) Diabetes , vol.36 , pp. 93-99
    • Tillil, H.1    Kobberling, J.2
  • 13
    • 0016746677 scopus 로고
    • Evidence for HL-A linked genes in "juvenile" diabetes mellitus
    • Cudworth AG, Woodrow JC: Evidence for HL-A linked genes in "juvenile" diabetes mellitus. Br Med J 3:133-135, 1975
    • (1975) Br Med J , vol.3 , pp. 133-135
    • Cudworth, A.G.1    Woodrow, J.C.2
  • 14
    • 0020574989 scopus 로고
    • A search for heterogeneity in insulin dependent diabetes mellitus (IDDM): HLA and autoimmune studies in simplex, multiplex and multigenerational families
    • Anderson CE, Hodge SE, Rubin R, Rotter JI, Terasaki PI, Irvine WJ, Rimoin DL: A search for heterogeneity in insulin dependent diabetes mellitus (IDDM): HLA and autoimmune studies in simplex, multiplex and multigenerational families. Metab Clin Exp 32:471-477, 1983
    • (1983) Metab Clin Exp , vol.32 , pp. 471-477
    • Anderson, C.E.1    Hodge, S.E.2    Rubin, R.3    Rotter, J.I.4    Terasaki, P.I.5    Irvine, W.J.6    Rimoin, D.L.7
  • 15
    • 0021719447 scopus 로고
    • Genetic heterogeneity of insulin-dependent (type 1) diabetes mellitus: Evidence from a study of extended haplotypes
    • Rich SS, Weitkamp LR, Barbosa J: Genetic heterogeneity of insulin-dependent (type 1) diabetes mellitus: Evidence from a study of extended haplotypes. Am J Hum Genet 36:1015-1023, 1984
    • (1984) Am J Hum Genet , vol.36 , pp. 1015-1023
    • Rich, S.S.1    Weitkamp, L.R.2    Barbosa, J.3
  • 16
    • 0023252262 scopus 로고
    • HLA-DQβ gene contributes to susceptibility and resistance to insulin dependent diabetes mellitus
    • Todd JA, Bell JI, McDevitt HO: HLA-DQβ gene contributes to susceptibility and resistance to insulin dependent diabetes mellitus. Nature 329:599-604, 1987
    • (1987) Nature , vol.329 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 17
    • 0001657878 scopus 로고
    • Aspartic acid at position 57 of the DQ beta chain protects against type 1 diabetes: A family study
    • Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M: Aspartic acid at position 57 of the DQ beta chain protects against type 1 diabetes: A family study. Proc Natl Acad Sci U S A 85:8111-8115, 1988
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 8111-8115
    • Morel, P.A.1    Dorman, J.S.2    Todd, J.A.3    McDevitt, H.O.4    Trucco, M.5
  • 18
    • 0029953008 scopus 로고    scopus 로고
    • The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 Caucasian, multiplex families
    • Noble JA, Valdes AM, Cook M, Klitz W, Thomson G, Erlich HA: The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet 59:1134-1148, 1996
    • (1996) Am J Hum Genet , vol.59 , pp. 1134-1148
    • Noble, J.A.1    Valdes, A.M.2    Cook, M.3    Klitz, W.4    Thomson, G.5    Erlich, H.A.6
  • 19
    • 0025896883 scopus 로고
    • Particular HLA-DQ alpha beta heterodimer associated with IDDM susceptibility in both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 whites
    • Ronningen KS, Gjertsen HA, Iwe T, Spurkland A, Hansen T, Thorsby E: Particular HLA-DQ alpha beta heterodimer associated with IDDM susceptibility in both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 whites. Diabetes 40:759-763, 1991
    • (1991) Diabetes , vol.40 , pp. 759-763
    • Ronningen, K.S.1    Gjertsen, H.A.2    Iwe, T.3    Spurkland, A.4    Hansen, T.5    Thorsby, E.6
  • 20
    • 0029144870 scopus 로고
    • Genetic susceptibility for IDDM in Caucasians revisited: The importance of diabetes registries in disclosing interactions between HLA-DQ and insulin gene-linked risk
    • Van der Auewra B, Schuit F, Lyaruu I, Falornio A, Svanholm S, Vanderwalle CL, Gorus FK: Genetic susceptibility for IDDM in Caucasians revisited: The importance of diabetes registries in disclosing interactions between HLA-DQ and insulin gene-linked risk. J Clin Endocrinol Metab 80:2567-2573, 1995
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2567-2573
    • Van der Auewra, B.1    Schuit, F.2    Lyaruu, I.3    Falornio, A.4    Svanholm, S.5    Vanderwalle, C.L.6    Gorus, F.K.7
  • 25
    • 0035078824 scopus 로고    scopus 로고
    • Transracial evidence for the influence of the homologous HLA DR-DQ haplotype on transmission of HLA DR4 haplotypes to diabetic children
    • Park YS, She JX, Noble JA, Erlich HA, Eisenbarth GS: Transracial evidence for the influence of the homologous HLA DR-DQ haplotype on transmission of HLA DR4 haplotypes to diabetic children. Tissue Antigens 57:185-191, 2001
    • (2001) Tissue Antigens , vol.57 , pp. 185-191
    • Park, Y.S.1    She, J.X.2    Noble, J.A.3    Erlich, H.A.4    Eisenbarth, G.S.5
  • 28
    • 0034522132 scopus 로고    scopus 로고
    • The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations
    • Lampis R, Morelli L, De Virgiliis S, Congia M, Cucca F: The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations. Tissue Antigens 6:515-521, 2000
    • (2000) Tissue Antigens , vol.6 , pp. 515-521
    • Lampis, R.1    Morelli, L.2    De Virgiliis, S.3    Congia, M.4    Cucca, F.5
  • 30
    • 0035311823 scopus 로고    scopus 로고
    • Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci
    • Zavattari P, Lampis R, Motzo C, Loddo M, Mulargia A, Whalen M, Maioli M, Angius E, Todd JA, Cucca F: Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci. Hum Mol Genet 10:881-889, 2001
    • (2001) Hum Mol Genet , vol.10 , pp. 881-889
    • Zavattari, P.1    Lampis, R.2    Motzo, C.3    Loddo, M.4    Mulargia, A.5    Whalen, M.6    Maioli, M.7    Angius, E.8    Todd, J.A.9    Cucca, F.10
  • 32
    • 0001017310 scopus 로고    scopus 로고
    • IDDM2-VNTR-encoded susceptibility to type 1 diabetes: Dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus
    • Bennett ST, Wilson AJ, Cucca F, Nerup J, Pociot F, McKinney PA, Barnett AJ, Bain SC, Todd JA: IDDM2-VNTR-encoded susceptibility to type 1 diabetes: Dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus. J Autoimmun 9:415-421, 1996
    • (1996) J Autoimmun , vol.9 , pp. 415-421
    • Bennett, S.T.1    Wilson, A.J.2    Cucca, F.3    Nerup, J.4    Pociot, F.5    McKinney, P.A.6    Barnett, A.J.7    Bain, S.C.8    Todd, J.A.9
  • 36
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese A, Zeller M, Fernandez A, Zalcberg LJ, Barnett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD: The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 15:293-297, 1997
    • (1997) Nat Genet , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez, A.3    Zalcberg, L.J.4    Barnett, R.J.5    Ricordi, C.6    Pietropaolo, M.7    Eisenbarth, G.S.8    Bennett, S.T.9    Patel, D.D.10
  • 43
    • 0035212224 scopus 로고    scopus 로고
    • A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: Identification of new loci with evidence of interactions
    • European Consortium for IDDM Genome Studies: A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: Identification of new loci with evidence of interactions. Am J Hum Genet 69:1301-1313, 2001
    • (2001) Am J Hum Genet , vol.69 , pp. 1301-1313
  • 45
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander ES, Kruglyak L: Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247, 1995
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.S.1    Kruglyak, L.2


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