Monte Carlo simulation of spontaneous miniature excitatory postsynaptic currents in rat hippocampal synapse in the presence and absence of desensitization

Pflugers Archiv European Journal of Physiology

Volumn 435, Issue 2, 1998, Pages 193-202

  Glavinović, Mladen I ^a   Rabie, Hamid R ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

AMPA receptor channels; Buffering; Desensitization; Glutamate; Monte Carlo method

Indexed keywords

AMPA RECEPTOR; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTEM ANALYSIS;

ANIMALS; BUFFERS; ELECTRIC CONDUCTIVITY; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; HIPPOCAMPUS; ION CHANNEL GATING; KINETICS; MONTE CARLO METHOD; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, AMPA; SYNAPSES;

EID: 0031909653     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050501     Document Type: Article

References (27)

1. Atassi B, Godfraind J-M, Glavinović MI (1996) Kinetics of spontaneous miniature excitatory postsynaptic currents in presence and in absence of cyclothiazide. Soc Neurosci Abstr 26: 1283p
2. Barbour B, Keller BU, Llano I, Marty A (1994) Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells. Neuron 12:1331-1343
3. Bartol TM Jr, Land BR, Salpeter EE, Salpeter MM (1991) Monte Carlo simulation of miniature endplate current generation in the vertebrate neuromuscular junction. Biophys J 59:1290-1307
4. Bekkers JM, Stevens CF (1996) Cable properties of cultured hippocampal neurons determined from sucrose-evoked miniature EPSCs. J Neurophysiol 75: 1250-1255
5. Bekkers JM, Richerson GB, Stevens CF (1990) Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices. Proc Natl Acad Sci USA 87:5359-5362
6. Clements JD, Lester RAJ, Tong G, Jahr CE, Westbrook GL (1992) The time course of glutamate in the synaptic cleft. Science 258:1498-1501
7. Colquhoun D, Jonas P, Sakmann B (1992) Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices. J Physiol (Lond) 458:261-287
8. Edmonds B, Gibb AJ, Colquhoun D (1995) Mechanisms of activation of glutamate receptors and the time course of excitatory synaptic currents. Annu Rev Physiol 57:495-519
9. Edwards FA, Konnerth A, Sakmann B (1990) Quantal synaptic transmission in the central nervous system: a patch clamp study of IPSCs in rat hippocampal slices. (Appendix by C. Busch). J Physiol (Lond) 430:231-249
10. Ghamari M, Glavinović MI (1995) Quantitative analysis of spontaneous excitatory quantal events in hippocampal pyramidal neurones. Can J Physiol Pharmacol 73:9p
11. Harris KM, Landis DMD (1986) Membrane structure at synaptic junctions in area CA1 of the rat hippocampus. Neuroscience 19:857-872
12. Hestrin S, Sah P, Nicoll R (1990) Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices. Neuron 5:247-253
13. Hille B (1992) Ionic channels of excitable membranes. Sinauer, Sutherland, Mass.
14. Issacson JS, Walmsley B (1996) Amplitude and time course of spontaneous and evoked excitatory postsynaptic currents in bushy cells of the anteroventral cochlear nucleus. J Neurophysiol 76:1566-1571
15. Johnston D, Brown TH (1983) Interpretation of voltage-clamp measurements in hippocampal neurons. J Neurophysiol 50: 464-486
16. Jonas P, Spruston N (1994) Mechanisms shaping glutamate- mediated excitatory postsynaptic currents in the CNS. Curr Opin Neurobiol 4:366-372
17. Jonas P, Major G, Sakmann B (1993) Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J Physiol (Lond) 472:615-663
18. Longsworth LG (1953) Diffusion measurements at 25°C, of aqueous solutions of amino acids, peptides and sugars. J Am Chem Soc 75:5705-5709
19. Raman IM, Trussell LO (1992) The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus. Neuron 9:173-186
20. Spruston N, Jonas P, Sakmann B (1995) Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J Physiol (Lond) 482:325-352
21. Takahashi M, Sarantis M, Attwell D (1996) Postsynaptic glutamate uptake in rat cerebellar Purkinje cells. J Physiol (Lond) 497:523-530
22. Tang C-M, Shi Q-Y, Katchman A, Lynch G (1991) Modulation of the time course of fast EPSCs and glutamate channel kinetics by Aniracetam. Science 254:288-290
23. Tong G, Jahr CE (1994) Multivesicular release from excitatory synapses of cultured hippocampal neurons. Neuron 12:51-59
24. Trussell LO, Fischbach GD (1989) Glutamate receptor desensitization and its role in synaptic transmission. Neuron 3: 209-218
25. Trussell LO, Zhang S, Raman IM (1993) Desensitization of AMPA receptors upon multiquantal neurotransmitter release. Neuron 10: 1185-1196
26. Wahl LM, Pouzat C, Stratford KJ (1996) Monte Carlo simulation of fast excitatory synaptic transmission at a hippocampal synapse. J Neurophysiol 75:597-608
27. Wathey JC, Nass, MM, Lester HA (1979) Numerical reconstruction of the quantal event at nicotinic synapses. Biophys J 27:145-164