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Volumn 189, Issue 10, 2004, Pages 1811-1820

Immunophenotypic Markers and Antiretroviral Therapy (IMART): T cell activation and maturation help predict treatment response

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD8 ANTIGEN; VIRUS RNA;

EID: 2442655107     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/383277     Document Type: Article
Times cited : (32)

References (78)
  • 1
    • 0034632793 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 RNA level and CD4 count as prognostic markers and surrogate endpoints: A meta-analysis
    • HIV Surrogate Marker Collaborative Group. Human immunodeficiency virus type 1 RNA level and CD4 count as prognostic markers and surrogate endpoints: a meta-analysis. AIDS Res Hum Retroviruses 2000; 16:1123-33.
    • (2000) AIDS Res Hum Retroviruses , vol.16 , pp. 1123-1133
  • 2
    • 0035808017 scopus 로고    scopus 로고
    • Predictors of virologic and clinical outcomes in HIV-1 infected patients receiving concurrent treatment with indinavir, zidovudine, and lamivudine
    • Demeter LM, Hughes MD, Coombs RW, et al. Predictors of virologic and clinical outcomes in HIV-1 infected patients receiving concurrent treatment with indinavir, zidovudine, and lamivudine. Ann Intern Med 2001; 135:954-64.
    • (2001) Ann Intern Med , vol.135 , pp. 954-964
    • Demeter, L.M.1    Hughes, M.D.2    Coombs, R.W.3
  • 4
    • 27744523877 scopus 로고    scopus 로고
    • The changing incidence of clinical AIDS events in 12,574 treatment-naïve patients starting HAART
    • abstract 569. (Boston). Alexandria, VA: Foundation for Retrovirology and Human Health
    • Sabin C, Monforte AD, May M, et al. The changing incidence of clinical AIDS events in 12,574 treatment-naïve patients starting HAART [abstract 569]. Tenth Conference on Retroviruses and Opportunistic Infections (Boston). Alexandria, VA: Foundation for Retrovirology and Human Health, 2003:261.
    • (2003) Tenth Conference on Retroviruses and Opportunistic Infections , pp. 261
    • Sabin, C.1    Monforte, A.D.2    May, M.3
  • 6
    • 10144260003 scopus 로고    scopus 로고
    • Association of plasma human immunodeficiency virus type 1 RNA level with risk of clinical progression in patients with advanced infection
    • Coombs RW, Welles SL, Hooper C, et al. Association of plasma human immunodeficiency virus type 1 RNA level with risk of clinical progression in patients with advanced infection. J Infect Dis 1996; 174:704-12.
    • (1996) J Infect Dis , vol.174 , pp. 704-712
    • Coombs, R.W.1    Welles, S.L.2    Hooper, C.3
  • 7
    • 0031029644 scopus 로고    scopus 로고
    • Perspective: Validating surrogate markers - Are we being naive?
    • De Gruttola V, Fleming T, Lin DY, Coombs RW. Perspective: validating surrogate markers - are we being naive? J Infect Dis 1997; 175:237-46.
    • (1997) J Infect Dis , vol.175 , pp. 237-246
    • De Gruttola, V.1    Fleming, T.2    Lin, D.Y.3    Coombs, R.W.4
  • 8
    • 0025015623 scopus 로고
    • On the use of laboratory markers as surrogates for clinical endpoints in the evaluation of treatment for HIV infection
    • Machado SG, Gail MH, Ellenberg SS. On the use of laboratory markers as surrogates for clinical endpoints in the evaluation of treatment for HIV infection. J Acquir Immune Defic Syndr 1990; 3:1065-73.
    • (1990) J Acquir Immune Defic Syndr , vol.3 , pp. 1065-1073
    • Machado, S.G.1    Gail, M.H.2    Ellenberg, S.S.3
  • 9
    • 0024520844 scopus 로고
    • Surrogate endpoints in clinical trials: Definition and operational criteria
    • Prentice RL. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med 1989; 8:431-40.
    • (1989) Stat Med , vol.8 , pp. 431-440
    • Prentice, R.L.1
  • 10
    • 0036534655 scopus 로고    scopus 로고
    • Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection
    • Giorgi JV, Lyles RH, Matud JL, et al. Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection. J Acquir Immune Defic Syndr 2002; 29:346-55.
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 346-355
    • Giorgi, J.V.1    Lyles, R.H.2    Matud, J.L.3
  • 12
    • 0032903843 scopus 로고    scopus 로고
    • The use of plasma HIV RNA as a study endpoint in efficacy trials of antiretroviral drugs
    • Murray JS, Elashoff MR, Iacono-Connors LC, Cvetkovich TA, Struble KA. The use of plasma HIV RNA as a study endpoint in efficacy trials of antiretroviral drugs. AIDS 1999; 13:797-804.
    • (1999) AIDS , vol.13 , pp. 797-804
    • Murray, J.S.1    Elashoff, M.R.2    Iacono-Connors, L.C.3    Cvetkovich, T.A.4    Struble, K.A.5
  • 13
    • 17344365057 scopus 로고    scopus 로고
    • Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: Results of AIDS Clinical Trials Group protocol 315
    • Lederman MM, Connick E, Landay A, et al. Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: results of AIDS Clinical Trials Group protocol 315. J Infect Dis 1998; 178:70-9.
    • (1998) J Infect Dis , vol.178 , pp. 70-79
    • Lederman, M.M.1    Connick, E.2    Landay, A.3
  • 14
    • 0032578860 scopus 로고    scopus 로고
    • Maintenance antiretroviral therapies in HIV-infected subjects with undetectable plasma HIV RNA after triple-drug therapy. AIDS Clinical Trials Group protocol 343
    • Havlir DV, Marschner IC, Hirsch MS, et al. Maintenance antiretroviral therapies in HIV-infected subjects with undetectable plasma HIV RNA after triple-drug therapy. AIDS Clinical Trials Group protocol 343. N Engl J Med 1998; 339:1261-8.
    • (1998) N Engl J Med , vol.339 , pp. 1261-1268
    • Havlir, D.V.1    Marschner, I.C.2    Hirsch, M.S.3
  • 15
    • 0035282636 scopus 로고    scopus 로고
    • Alterations in T cell phenotype and human immunodeficiency virus type 1-specific cytotoxicity after potent antiretroviral therapy. AIDS Clinical Trials Group protocol 879
    • Seth A, Markee J, Hoering A, et al. Alterations in T cell phenotype and human immunodeficiency virus type 1-specific cytotoxicity after potent antiretroviral therapy. AIDS Clinical Trials Group protocol 879. J Infect Dis 2001; 183:722-9.
    • (2001) J Infect Dis , vol.183 , pp. 722-729
    • Seth, A.1    Markee, J.2    Hoering, A.3
  • 16
    • 0036175377 scopus 로고    scopus 로고
    • Evidence of immune reconstitution in antiretroviral drug-experienced patients with advanced HIV disease. AIDS Clinical Trials Group protocol 890
    • Landay AL, Bettendorf D, Chan E, et al. Evidence of immune reconstitution in antiretroviral drug-experienced patients with advanced HIV disease. AIDS Clinical Trials Group protocol 890. AIDS Res Hum Retroviruses 2002; 18:95-102.
    • (2002) AIDS Res Hum Retroviruses , vol.18 , pp. 95-102
    • Landay, A.L.1    Bettendorf, D.2    Chan, E.3
  • 17
    • 0345012053 scopus 로고    scopus 로고
    • Comparison on sequential three-drug regimens as initial therapy for HIV-1 infection
    • Robbins G-K, De Gruttola V, Shafer RW, et al. Comparison on sequential three-drug regimens as initial therapy for HIV-1 infection. N Engl J Med 2003; 349:2293-303.
    • (2003) N Engl J Med , vol.349 , pp. 2293-2303
    • Robbins, G.-K.1    De Gruttola, V.2    Shafer, R.W.3
  • 19
    • 0034672295 scopus 로고    scopus 로고
    • Analysis and design issues for studies using censored biomarker measurements with an example of viral load measurements in HIV clinical trials
    • Hughes MD. Analysis and design issues for studies using censored biomarker measurements with an example of viral load measurements in HIV clinical trials. Stat Med 2000; 19:3171-91.
    • (2000) Stat Med , vol.19 , pp. 3171-3191
    • Hughes, M.D.1
  • 20
    • 0001600762 scopus 로고
    • Information gain and a general measure of correlation
    • Kent JT. Information gain and a general measure of correlation. Biometrika 1983; 70:163-73.
    • (1983) Biometrika , vol.70 , pp. 163-173
    • Kent, J.T.1
  • 21
    • 0037183954 scopus 로고    scopus 로고
    • Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease
    • Valdez H, Connick E, Smith KY, et al. Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease. AIDS 2002; 16:1859-66.
    • (2002) AIDS , vol.16 , pp. 1859-1866
    • Valdez, H.1    Connick, E.2    Smith, K.Y.3
  • 22
    • 0030052964 scopus 로고    scopus 로고
    • Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir
    • Kelleher AD, Carr, Zaunders J, et al. Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J Infect Dis 1996; 173:321-9.
    • (1996) J Infect Dis , vol.173 , pp. 321-329
    • Kelleher, A.D.1    Carr2    Zaunders, J.3
  • 23
    • 0030868897 scopus 로고    scopus 로고
    • + T cell homeostasis and function in advanced HIV disease
    • + T cell homeostasis and function in advanced HIV disease. Science 1997; 277:112-6.
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1    Carcelain, G.2    Li, T.S.3
  • 24
    • 0033984368 scopus 로고    scopus 로고
    • Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response
    • Connick E, Lederman MM, Kotzin BL, et al. Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response. J Infect Dis 2000; 181:358-63.
    • (2000) J Infect Dis , vol.181 , pp. 358-363
    • Connick, E.1    Lederman, M.M.2    Kotzin, B.L.3
  • 25
    • 0031882434 scopus 로고    scopus 로고
    • Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
    • Pakker NG, Notermans DW, de Boer RJ, et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med 1998; 4:208-14.
    • (1998) Nat Med , vol.4 , pp. 208-214
    • Pakker, N.G.1    Notermans, D.W.2    De Boer, R.J.3
  • 26
    • 0035894169 scopus 로고    scopus 로고
    • Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection
    • Ammassari A, Murri R, Pezzotti P, et al. Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection. J Acquir Immune Defic Syndr 2001; 28:445-9.
    • (2001) J Acquir Immune Defic Syndr , vol.28 , pp. 445-449
    • Ammassari, A.1    Murri, R.2    Pezzotti, P.3
  • 27
    • 0037090271 scopus 로고    scopus 로고
    • The consistency of adherence to antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials
    • Mannheimer S, Friedland G, Matts J, Child C, Chesney M. The consistency of adherence to antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials. Clin Infect Dis 2002; 34:1115-21.
    • (2002) Clin Infect Dis , vol.34 , pp. 1115-1121
    • Mannheimer, S.1    Friedland, G.2    Matts, J.3    Child, C.4    Chesney, M.5
  • 28
    • 0036222752 scopus 로고    scopus 로고
    • Adherence to highly active antiretroviral therapies (HAART) in HIV-infected patients: From a predictive to a dynamic approach
    • Spire B, Duran S, Souville M, Leport C, Raffi F, Moatti JP. Adherence to highly active antiretroviral therapies (HAART) in HIV-infected patients: from a predictive to a dynamic approach. Soc Sci Med 2002; 54: 1481-96.
    • (2002) Soc Sci Med , vol.54 , pp. 1481-1496
    • Spire, B.1    Duran, S.2    Souville, M.3    Leport, C.4    Raffi, F.5    Moatti, J.P.6
  • 29
    • 0011419832 scopus 로고    scopus 로고
    • Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: Relationships to host factors, cellular restoration, and virologic end points
    • Wu H, Kuritzkes D, McClernon DR, et al. Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points. J Infect Dis 1999; 179:799-807.
    • (1999) J Infect Dis , vol.179 , pp. 799-807
    • Wu, H.1    Kuritzkes, D.2    McClernon, D.R.3
  • 33
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • Giorgi JV, Hultin LE, McKeating JA, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999; 179:859-70.
    • (1999) J Infect Dis , vol.179 , pp. 859-870
    • Giorgi, J.V.1    Hultin, L.E.2    McKeating, J.A.3
  • 35
    • 0031042577 scopus 로고    scopus 로고
    • Quantitative alterations of the functionally distinct subsets of CD4 and CD8 lymphocytes in asymptomatic infection: Changes in the expression of CD45RO, CD45RA, CD11b, CD38, HLA-DR, and CD25 antigens
    • Benito JM, Zabay JM, Gil J, et al. Quantitative alterations of the functionally distinct subsets of CD4 and CD8 lymphocytes in asymptomatic infection: changes in the expression of CD45RO, CD45RA, CD11b, CD38, HLA-DR, and CD25 antigens. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 14:128-35.
    • (1997) J Acquir Immune Defic Syndr Hum Retrovirol , vol.14 , pp. 128-135
    • Benito, J.M.1    Zabay, J.M.2    Gil, J.3
  • 37
    • 0032581692 scopus 로고    scopus 로고
    • + lymphocyte activation status and plasma RNA levels during antiretroviral therapy
    • + lymphocyte activation status and plasma RNA levels during antiretroviral therapy. AIDS 1998; 12:1267-73.
    • (1998) AIDS , vol.12 , pp. 1267-1273
    • Bouscarat, F.1    Levacher, M.2    Landman, R.3
  • 38
    • 0037040375 scopus 로고    scopus 로고
    • ++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection
    • ++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection. AIDS 2002; 16:589-96.
    • (2002) AIDS , vol.16 , pp. 589-596
    • Tilling, R.1    Kinloch, S.2    Goh, L.3
  • 39
    • 0032512268 scopus 로고    scopus 로고
    • Expression of CD38 on CD8 T cells predicts maintenance of high viraemia in HAART-treated HIV-1 infected children
    • Vigano A, Saresella M, Rusconi S, Ferrante P, Clerici M. Expression of CD38 on CD8 T cells predicts maintenance of high viraemia in HAART-treated HIV-1 infected children. Lancet 1998; 352:1905-6.
    • (1998) Lancet , vol.352 , pp. 1905-1906
    • Vigano, A.1    Saresella, M.2    Rusconi, S.3    Ferrante, P.4    Clerici, M.5
  • 41
    • 0036570559 scopus 로고    scopus 로고
    • Impact of suppression of viral replication by highly active antiretroviral therapy on immune function and phenotype in chronic HIV-1 infection
    • Lange CG, Lederman MM, Madero JS, et al. Impact of suppression of viral replication by highly active antiretroviral therapy on immune function and phenotype in chronic HIV-1 infection. J Acquir Immune Defic Syndr 2002; 30:33-40.
    • (2002) J Acquir Immune Defic Syndr , vol.30 , pp. 33-40
    • Lange, C.G.1    Lederman, M.M.2    Madero, J.S.3
  • 42
    • 0036392037 scopus 로고    scopus 로고
    • Correlates of antiviral immune restoration in acute and chronic HIV type 1 infection: Sustained viral suppression and normalization of T cell subsets
    • Dyer WB, Kuipers H, Coolen MW, et al. Correlates of antiviral immune restoration in acute and chronic HIV type 1 infection: sustained viral suppression and normalization of T cell subsets. AIDS Res Hum Retroviruses 2002; 18:999-1010.
    • (2002) AIDS Res Hum Retroviruses , vol.18 , pp. 999-1010
    • Dyer, W.B.1    Kuipers, H.2    Coolen, M.W.3
  • 43
    • 0033503076 scopus 로고    scopus 로고
    • Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: Partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremia
    • Zaunders JJ, Cunningham PH, Kelleher AD, et al. Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremia. J Infect Dis 1999; 180:320-9.
    • (1999) J Infect Dis , vol.180 , pp. 320-329
    • Zaunders, J.J.1    Cunningham, P.H.2    Kelleher, A.D.3
  • 44
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang L, Ramratnam B, Tenner-Racz K, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999; 340:1605-13.
    • (1999) N Engl J Med , vol.340 , pp. 1605-1613
    • Zhang, L.1    Ramratnam, B.2    Tenner-Racz, K.3
  • 45
    • 0033609374 scopus 로고    scopus 로고
    • Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
    • Furtado MR, Callaway DS, Phair JP, et al. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999; 340:1614-22.
    • (1999) N Engl J Med , vol.340 , pp. 1614-1622
    • Furtado, M.R.1    Callaway, D.S.2    Phair, J.P.3
  • 46
    • 0035341524 scopus 로고    scopus 로고
    • Residual human immunodeficiency virus (HIV) type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years
    • Gunthard HF, Havlir D, Fiscus S, et al. Residual human immunodeficiency virus (HIV) type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years. J Infect Dis 2001; 183:1318-27.
    • (2001) J Infect Dis , vol.183 , pp. 1318-1327
    • Gunthard, H.F.1    Havlir, D.2    Fiscus, S.3
  • 47
    • 0036263070 scopus 로고    scopus 로고
    • Detection of replication-competent human immunodeficiency virus type 1 (HIV-1) in cultures from patients with levels of HIV-1 RNA in plasma suppressed to less than 500 or 50 copies per milliliter
    • Demeter LM, Bosch RJ, Coombs RW, et al. Detection of replication- competent human immunodeficiency virus type 1 (HIV-1) in cultures from patients with levels of HIV-1 RNA in plasma suppressed to less than 500 or 50 copies per milliliter. J Clin Microbiol 2002; 40:2089-94.
    • (2002) J Clin Microbiol , vol.40 , pp. 2089-2094
    • Demeter, L.M.1    Bosch, R.J.2    Coombs, R.W.3
  • 48
    • 0026755629 scopus 로고
    • Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus
    • Layne SP, Merges MJ, Dembo M, et al. Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus. Virology 1992; 189:695-714.
    • (1992) Virology , vol.189 , pp. 695-714
    • Layne, S.P.1    Merges, M.J.2    Dembo, M.3
  • 49
    • 0027410369 scopus 로고
    • High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR
    • Piatak M, Saag MS, Yang LC, et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 1993; 259:1749-54.
    • (1993) Science , vol.259 , pp. 1749-1754
    • Piatak, M.1    Saag, M.S.2    Yang, L.C.3
  • 50
    • 0035964691 scopus 로고    scopus 로고
    • Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function
    • Teixeira L, Valdez H, McCune JM, et al. Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS 2001; 15:1749-56.
    • (2001) AIDS , vol.15 , pp. 1749-1756
    • Teixeira, L.1    Valdez, H.2    McCune, J.M.3
  • 53
    • 0033394585 scopus 로고    scopus 로고
    • Immune reconstitution after 2 years of successful potent antiretroviral therapy in previously untreated human immunodeficiency virus type 1-infected adults
    • Notermans DW, Pakker NG, Hamann D, et al. Immune reconstitution after 2 years of successful potent antiretroviral therapy in previously untreated human immunodeficiency virus type 1-infected adults. J Infect Dis 1999; 180:1050-6.
    • (1999) J Infect Dis , vol.180 , pp. 1050-1056
    • Notermans, D.W.1    Pakker, N.G.2    Hamann, D.3
  • 55
    • 0343920019 scopus 로고    scopus 로고
    • T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: A longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)
    • Hazenberg MD, Stuart JW, Otto SA, et al. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 2000; 95:249-55.
    • (2000) Blood , vol.95 , pp. 249-255
    • Hazenberg, M.D.1    Stuart, J.W.2    Otto, S.A.3
  • 56
    • 0036169688 scopus 로고    scopus 로고
    • + count in HIV-infected patients at time of initiation of highly active antiretroviral therapy is strongly associated with the level of immunological recovery
    • + count in HIV-infected patients at time of initiation of highly active antiretroviral therapy is strongly associated with the level of immunological recovery. Scand J Infect Dis 2002; 34:45-9.
    • (2002) Scand J Infect Dis , vol.34 , pp. 45-49
    • Michael, C.G.1    Kirk, O.2    Mathiesen, L.3    Nielsen, S.D.4
  • 58
    • 0036179384 scopus 로고    scopus 로고
    • + T-lymphocyte nadir and the effect of highly active antiretroviral therapy on phenotypic and functional immune restoration in HIV-1 infection
    • + T-lymphocyte nadir and the effect of highly active antiretroviral therapy on phenotypic and functional immune restoration in HIV-1 infection. Clin Immunol 2002; 102:154-61.
    • (2002) Clin Immunol , vol.102 , pp. 154-161
    • Lange, C.G.1    Valdez, H.2    Medvik, K.3    Asaad, R.4    Lederman, M.M.5
  • 59
    • 0023694580 scopus 로고
    • AIDS as immune system activation: A model for pathogenesis
    • Ascher MS, Sheppard HW. AIDS as immune system activation: a model for pathogenesis. Clin Exp Immunol 1988; 73:165-7.
    • (1988) Clin Exp Immunol , vol.73 , pp. 165-167
    • Ascher, M.S.1    Sheppard, H.W.2
  • 60
    • 0030915369 scopus 로고    scopus 로고
    • T cell homeostasis in HIV infection is neither failing nor blind: Modified cell counts reflect an adaptive response of the host
    • Grossman Z, Herberman RB. T cell homeostasis in HIV infection is neither failing nor blind: modified cell counts reflect an adaptive response of the host. Nat Med 1997; 3:486-90.
    • (1997) Nat Med , vol.3 , pp. 486-490
    • Grossman, Z.1    Herberman, R.B.2
  • 61
    • 0032032504 scopus 로고    scopus 로고
    • Direct HIV cytopathicity cannot account for CD4 decline in AIDS in the presence of homeostasis: A worst-case dynamic analysis
    • Anderson RW, Ascher MS, Sheppard HW. Direct HIV cytopathicity cannot account for CD4 decline in AIDS in the presence of homeostasis: a worst-case dynamic analysis. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 17:245-52.
    • (1998) J Acquir Immune Defic Syndr Hum Retrovirol , vol.17 , pp. 245-252
    • Anderson, R.W.1    Ascher, M.S.2    Sheppard, H.W.3
  • 64
    • 0037105617 scopus 로고    scopus 로고
    • CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly linked to the viral load
    • Sousa AE, Carneiro J, Meier-Schellersheim M, Grossman Z, Victorino RMM. CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly linked to the viral load. J Immunol 2002; 169:3400-6.
    • (2002) J Immunol , vol.169 , pp. 3400-3406
    • Sousa, A.E.1    Carneiro, J.2    Meier-Schellersheim, M.3    Grossman, Z.4    Victorino, R.M.M.5
  • 65
    • 0031751647 scopus 로고    scopus 로고
    • + T cells correlate with plasma human immunodeficiency virus (HIV-1) RNA level in HIV infection
    • + T cells correlate with plasma human immunodeficiency virus (HIV-1) RNA level in HIV infection. J Infect Dis 1998; 178: 1279-87.
    • (1998) J Infect Dis , vol.178 , pp. 1279-1287
    • Orendi, J.M.1    Bloem, A.C.2    Borleffs, J.C.3
  • 66
    • 0034523322 scopus 로고    scopus 로고
    • Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of HIV-infected drug users
    • Carbone J, Gil J, Benito JM, et al. Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of HIV-infected drug users. AIDS 2000; 14:2823-9.
    • (2000) AIDS , vol.14 , pp. 2823-2829
    • Carbone, J.1    Gil, J.2    Benito, J.M.3
  • 67
    • 0030026189 scopus 로고    scopus 로고
    • + T cells is markedly enhanced in the setting of antigen-specific immune activation
    • + T cells is markedly enhanced in the setting of antigen-specific immune activation. J Exp Med 1996; 183:687-92.
    • (1996) J Exp Med , vol.183 , pp. 687-692
    • Weissman, D.1    Barker, T.D.2    Fauci, A.S.3
  • 69
    • 0034767911 scopus 로고    scopus 로고
    • Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency type 1 infection
    • Lawn SD, Butera ST, Folks TM. Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency type 1 infection. Clin Microbiol Rev 2001; 14:753-77.
    • (2001) Clin Microbiol Rev , vol.14 , pp. 753-777
    • Lawn, S.D.1    Butera, S.T.2    Folks, T.M.3
  • 70
    • 0032741277 scopus 로고    scopus 로고
    • + lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues
    • + lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest 1999; 103:1391-8.
    • (1999) J Clin Invest , vol.103 , pp. 1391-1398
    • Bucy, R.P.1    Hockett, R.D.2    Derdeyn, C.A.3
  • 71
    • 0035423912 scopus 로고    scopus 로고
    • Immune activation correlates better than HIV plasma viral load with CD4 T-cell decline during HIV infection
    • Leng Q, Borkow G, Weisman Z, Stein M, Kalinkovich A, Bentwich Z. Immune activation correlates better than HIV plasma viral load with CD4 T-cell decline during HIV infection. J Acquir Immune Defic Syndr 2001; 27:389-97.
    • (2001) J Acquir Immune Defic Syndr , vol.27 , pp. 389-397
    • Leng, Q.1    Borkow, G.2    Weisman, Z.3    Stein, M.4    Kalinkovich, A.5    Bentwich, Z.6
  • 72
    • 0038701685 scopus 로고    scopus 로고
    • + T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
    • + T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 2003; 187:1534-43.
    • (2003) J Infect Dis , vol.187 , pp. 1534-1543
    • Hunt, P.W.1    Martin, J.D.2    Sinclair, E.3
  • 74
    • 0030055847 scopus 로고    scopus 로고
    • CD4 and total lymphocyte counts as predictors of HIV disease progression
    • Post FA, Wood R, Maartens G. CD4 and total lymphocyte counts as predictors of HIV disease progression. Q J Med 1996; 89:505-8.
    • (1996) Q J Med , vol.89 , pp. 505-508
    • Post, F.A.1    Wood, R.2    Maartens, G.3
  • 75
    • 0029826852 scopus 로고    scopus 로고
    • Correlation between total and CD4 lymphocyte counts in HIV infection: Not making the good an enemy of the not so perfect
    • Beck EJ, Kupek EJ, Gompels MM, Pinching AJ. Correlation between total and CD4 lymphocyte counts in HIV infection: not making the good an enemy of the not so perfect. Int J STD AIDS 1996; 7:422-8.
    • (1996) Int J STD AIDS , vol.7 , pp. 422-428
    • Beck, E.J.1    Kupek, E.J.2    Gompels, M.M.3    Pinching, A.J.4
  • 76
    • 18044403827 scopus 로고    scopus 로고
    • An evaluation of low-cost progression markers in HIV-1 seropositive Zambians
    • Hosp M, Lisse IM, Quigley M, et al. An evaluation of low-cost progression markers in HIV-1 seropositive Zambians. HIV Med 2000; 1:125-7.
    • (2000) HIV Med , vol.1 , pp. 125-127
    • Hosp, M.1    Lisse, I.M.2    Quigley, M.3
  • 77
    • 0036892029 scopus 로고    scopus 로고
    • Total lymphocyte count (TLC) is a useful tool for the timing of opportunistic infection prophylaxis in India and other resource-constrained countries
    • Kumarasamy N, Mahajan AP, Flanigan TP, et al. Total lymphocyte count (TLC) is a useful tool for the timing of opportunistic infection prophylaxis in India and other resource-constrained countries. J Acquir Immune Defic Syndr 2002; 31:378-83.
    • (2002) J Acquir Immune Defic Syndr , vol.31 , pp. 378-383
    • Kumarasamy, N.1    Mahajan, A.P.2    Flanigan, T.P.3
  • 78
    • 0037414994 scopus 로고    scopus 로고
    • Rapid declines in total lymphocyte count and hemoglobin in HIV infection begin at CD4 lymphocyte counts that justify antiretroviral therapy
    • Gange SJ, Lau B, Phair J, Riddler SA, Detels R, Margolick JB. Rapid declines in total lymphocyte count and hemoglobin in HIV infection begin at CD4 lymphocyte counts that justify antiretroviral therapy. AIDS 2003; 17:119-21.
    • (2003) AIDS , vol.17 , pp. 119-121
    • Gange, S.J.1    Lau, B.2    Phair, J.3    Riddler, S.A.4    Detels, R.5    Margolick, J.B.6


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