Protein kinase C effects on nerve function, perfusion, Na+,K+-ATPase activity and glutathione content in diabetic rats

Diabetologia

Volumn 42, Issue 9, 1999, Pages 1120-1130

  Cameron, N E ^a,c   Cotter, M A ^a   Jack, A M ^a   Basso, M D ^b   Hohman, T C ^b  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b PFIZER INC   (United States)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Blood flow, protein kinase C; Diabetic rat; Diacylglycerol; Nerve conduction; Neuropathy; Oxidative stress

Indexed keywords

2,6 DIAMINO N [[1 (1 OXOTRIDECYL) 2 PIPERIDYL]METHYL]HEXANAMIDE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CHELERYTHRINE; GLUTATHIONE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STREPTOZOCIN; UNCLASSIFIED DRUG; WAY 151003;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; MALE; NERVE CONDUCTION; NEUROPROTECTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; ENZYME INHIBITORS; MALE; NA(+)-K(+)-EXCHANGING ATPASE; NEURAL CONDUCTION; PHENANTHRIDINES; PIPERIDINES; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; SCIATIC NERVE;

EID: 0032842640     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051280     Document Type: Article

References (61)

1. Koya D, King GL (1998) Protein kinase C activation and the development of diabetic complications. Diabetes 47: 859-866
2. Ishii H, Jirousek MR, Koya D et al. (1996) Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor. Science 272: 728-731
3. Kim J, Rushovich EH, Thomas TP, Ueda T, Agranoff BW, Greene DA (1991) Diminished specific activity of cytosolic protein kinase C in sciatic nerve of streptozocin-diabetic rats and its correction by dietary myo-inositol. Diabetes 40: 1545-1554
4. Borghini I, Ania-Lahuerta A, Regazzi R et al. (1994) α βI, βII, δ, and ε protein kinase C isoforms and compound activity in the sciatic nerve of normal and diabetic rats. J Neurochem 62: 686-696
5. Mathew J, Bianchi R, McLean WG et al. (1997) Phosphoinositide metabolism, Na,K-ATPase and protein kinase C are altered in peripheral nerve from Zucker diabetic fatty rats (ZDF/Gmi-f alpha). Neurosci Res Commun 20: 21-30
6. Roberts RE, McLean WG (1997) Protein kinase C isozyme expression in sciatic nerves and spinal cords of experimentally diabetic rats. Brain Res 754: 147-156
7. Greene DA, Sima AAF, Stevens MJ, Feldman EL, Lattimer SA (1992) Complications: neuropathy, pathogenetic considerations. Diabetes Care 15: 1902-1925
8. Low PA, Lagerlund TD, McManis PG (1989) Nerve blood flow and oxygen delivery in normal, diabetic and ischemic neuropathy. Int Rev Neurobiol 31: 355-438
9. Tesfaye S, Malik R, Ward JD (1994) Vascular factors in diabetic neuropathy. Diabetologia 37: 847-854
10. Cameron NE, Cotter MA (1997) Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes 46 [Suppl 2]: S31-S37
11. 1 receptor antagonist. Am J Physiol 269: E530-E537
12. Hotta N, Koh N, Sakakibara F et al. (1996) Effects of beraprost sodium and insulin on the electroretinogram, nerve conduction and nerve blood flow in rats with streptozotocin-induced diabetes. Diabetes 45: 361-366
13. Shimamoto Y, Shimamoto H, Kwan C, Daniel EE (1993) Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle. Am J Physiol 264: H1300-H1306
14. Cohen RA (1993) Dysfunction of vascular endothelium in diabetes mellitus. Circulation 87 [Suppl V]: V67-V76
15. Kamata K, Chikada S, Umeda F, Kasuya Y (1995) Effects of phorbol ester on vasodilation induced by endothelium-dependent or endothelium-independent vasodilators in the mesenteric arterial bed. J Cardiovasc Pharmacol 26: 645-652
16. Kihara M, Low PA (1995) Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy. Exp Neurol 132: 180-185
17. Maxfield EK, Cameron NE, Cotter MA (1997) Effects of diabetes on reactivity of sciatic vasa nervorum in rats. J Diabet Complications 11: 47-55
18. Pelligrino DA, Koenig HM, Wang Q, Albrecht RF (1994) Protein kinase C suppresses receptor-mediated pial arteriolar relaxation in the diabetic rat. Neuroreport 5: 417-420
19. Mayhan WG, Patel KP (1995) Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C. Am J Physiol 269: H1297-H1302
20. Nagamatsu M, Nickander KK, Schmelzer JD et al. (1995) Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18: 1160-1167
21. Hohman TC, Banas D, Basso M, Cotter MA, Cameron NE (1997) Increased oxidative stress in experimental diabetic neuropathy. Diabetologia 40 [Suppl 1]: A549 (Abstract)
22. Cameron NE, Cotter MA, Dines KC, Maxfield EK, Carey F, Mirrlees DJ (1994) Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: dose-response considerations and independence from a myo-inositol mechanism. Diabetologia 37: 651-663
23. Sullivan JP, Connor JR, Shearer BG, Burch RM (1992) 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl) hexanamide (NPC 15 437): A novel inhibitor of protein kinase C interacting at the regulatory domain. Mol Pharmacol 41: 38-44
24. Herbert JM, Augereau JM, Gleye J, Maffrand JP (1990) Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 172: 993-999
25. Yagihashi S (1995) Pathology and pathogenetic mechanisms of diabetic neuropathy. Diabetes Metab Rev 11: 193-225
26. Cameron NE, Cotter MA, Dines KC, Maxfield EK (1993) Pharmacological manipulation of vascular endothelium in non-diabetic and streptozotocin-diabetic rats: effects on nerve conduction, hypoxic resistance and endoneurial capillarization. Diabetologia 36: 516-522
27. Cameron NE, Cotter MA, Hohman TC (1996) Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. Diabetologia 39: 172-182
28. Cameron NE, Cotter MA, Robertson S (1989) The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats. Q J Exp Physiol 74: 917-926
29. Cameron NE, Cotter MA, Basso M, Hohman TC (1997) Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats. Diabetologia 40: 271-281
30. +-ATPase activity. Methods in Enzymology 156: 116-119
31. +-ATPase activity in isolated membrane fraction from sciatic nerves of streptozocin-induced diabetic rats by dietary myo-inositol supplementation in vivo or protein kinase C agonists in vitro. Diabetes 40: 558-567
32. Sredy J, Flam BR, Sawicki DR (1991) Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effects of aldose reductase inhibitors. Proc Soc ExpBiol Med 197: 135-142
33. Baker MA, Cerniglia GJ, Zaman A (1990) Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Analytical Biochem 190: 360-365
34. Preiss JE, Loomis CR, Bell RM, Niedel JE (1987) Quantitative measurement of sn-1,2 diacylglycerols. Methods in Enzymology 141: 294-300
35. Zhu X, Eichberg J (1990) 1,2 Diacylglycerol content and its arachidonyl-containing molecular species are reduced in sciatic nerve from streptozotocin-induced diabetic rats. J Neurochem 55: 1087-1090
36. Cho Y, Ziboh VA (1994) 13-Hydroxyoctadecadienoic acid reverses epidermal hyperproliferation via selective inhibition of protein kinase C-β activity. Biochem Biophys Res Commun 201: 257-265
37. Cho Y, Ziboh VA (1995) Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective downregulation of protein kinase C-β. J Nutr 125: 2741-2750
38. Cameron NE, Jack A, Ways DK, Cotter MA (1998) Effects of the protein kinase Cβ inhibitor, LY333531, on nerve and vascular function in diabetic rats. Diabetologia 41 [Suppl 1]: A54. (Abstract)
39. Borghini I, Geering K, Gjinovci A, Wollheim CB, Pralong WF (1994) In vivo phosphorylation of the Na,K-ATPase alpha subunit in sciatic nerves of control and diabetic rats: effects of protein kinase modulators. Proc Natl Acad Sci USA 91: 6211-6215
40. Stevens MJ, Lattimer SA, Feldman EL et al. (1996) Acetyl-L-carnitine deficiency as a cause of altered nerve myoinositol content Na,K-ATPase activity and motor conduction velocity in the streptozotocin-diabetic rat. Metabolism 45: 865-872
41. Cotter MA, Cameron NE, Keegan A, Dines KC (1995) Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. Metabolism 44: 1209-1214
42. +-ATPase activity, and vascular supply in STZ-D rats. Diabetes 40: 1652-1658
43. + pumpin streptozotocin-diabetic rats. Br J Pharmacol 105: 355-360
44. 2. J Clin Invest 96: 733-740
45. Cotter MA, Love A, Watt MJ, Cameron NE, Dines KC (1995) Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats. Diabetologia 38: 1285-1294
46. Cameron NE, Cotter MA (1995) Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents. J Clin Invest 96: 1159-1163
47. Love A, Cotter MA, Cameron NE (1996) Effects of the sulphydryl donor N-acetyl-L-cysteine on nerve conduction, perfusion, maturation and regeneration following freeze damage in diabetic rats. Eur J Clin Invest 26: 698-706
48. +)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat. J Clin Invest 94: 853-859
49. Ritchie JM (1985) A note on the mechanism of resistance to anoxia and ischaemia in the pathophysiological mammalian myelinated nerve. J Neurol Neurosurg Psychiatry 48: 274-277
50. Obrosova I, Van Heyningen D, Cao X, Stevens M, Greene D (1997) Metabolic compensations for diabetes-induced endoneurial hypoxia. J Peripher Nerv Syst 2: 290 (Abstract)
51. Numaguchi K, Shimokawa H, Nakaike R, Egashira K, Takeshita A (1996) PKC inhibitors prevent endothelial dysfunction after myocardial ischemia-reperfusion in rats. Am J Physiol 270: H1634-H1639
52. Keaney JF Jr, Guo Y, Cunningham D, Shwaery GT, Xu A, Vita JA (1996) Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation. J Clin Invest 98: 386-394
53. Cameron NE, Cotter MA, Horrobin DH, Tritschler HJ (1998) Effects of α-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Diabetologia 41: 390-399
54. Cameron NE, Cotter MA (1995) Reversal of peripheral nerve conduction and perfusion deficits by the free radical scavenger, BM 15639, in diabetic rats. Naunyn-Schmeideberg's Arch Pharmacol 352: 685-690
55. Sagara M, Satoh J, Wada R et al. (1996) Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with n-acetylcysteine. Diabetologia 39: 263-269
56. Hirata K, Kuroda R, Sakoda T et al. (1995) Inhibition of endothelial nitric oxide synthase activity by protein kinase C. Hypertension 25: 180-185
57. Ohara Y, Sayegh HS, Yamin JJ, Harrison DG (1995) Regulation of endothelial constitutive nitric oxide synthase by protein kinase C. Hypertension 25: 415-420
58. Rubanyi GM, Polokoff MA (1994) Endothelins: m2olecular biology, biochemistry, pharmacology, physiology and pathophysiology. Pharmacol Rev 46: 325-415
59. + currents in rat arterial smooth muscle through protein kinase C. J Physiol 503: 489-496
60. A antagonist on neurovascular function in diabetic rats: interaction with the renin-angiotensin system. J Pharmacol Exp Ther 278: 1262-1268
61. Nakamura J, Koh N, Hamada Y et al. (1998) Effect of a protein kinase C-β specific inhibitor on diabetic neuropathy in rats. Diabetes 47 [Suppl 1]: A70. (Abstract)