Functional knockdown of neuropilin-1 in the developing chick nervous system by siRNA hairpins phenocopies genetic ablation in the mouse

Developmental Dynamics

Volumn 230, Issue 2, 2004, Pages 299-308

  Bron, Romke ^a   Eickholt, Britta J ^a   Vermeren, Matthieu ^a   Fragale, Ninfa ^a   Cohen, James ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Axon guidance; Chick embryo; Nervous system; Neuropilin; Semaphorin; siRNA

Indexed keywords

MEMBRANE RECEPTOR; MUTANT PROTEIN; NEUROPILIN 1; NEUROPILIN 1 RECEPTOR; NEUROPILIN 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; GENE CONTROL; GENE FUNCTION; GROWTH CONE; KNOCKOUT GENE; MOUSE; NERVE FIBER; NERVE PROJECTION; NERVOUS SYSTEM DEVELOPMENT; NEURAL CREST CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RNA INTERFERENCE; SPINAL GANGLION; SYMPATHETIC TRUNK; VENTRAL ROOT; VERTEBRATE;

ANIMALS; BIRDS; CELL DIFFERENTIATION; CELLS, CULTURED; CHICK EMBRYO; CHICKENS; GANGLIA, SPINAL; GENE DELETION; GENETIC VECTORS; MICE; MICE, KNOCKOUT; NERVOUS SYSTEM; NEURAL CREST; NEUROPILIN-1; NUCLEIC ACID CONFORMATION; PHENOTYPE; PROMOTER REGIONS (GENETICS); RNA, SMALL INTERFERING; RNA, SMALL NUCLEAR;

VERTEBRATA;

EID: 2442651549     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.20043     Document Type: Article

References (44)

1. Agami R. 2002. RNAi and related mechanisms and their potential use for therapy. Curr Opin Chem Biol 6:829-834.
2. Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC. 1996. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature 383:525-528.
3. Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ. 2002. A comprehensive collection of chicken cDNAs. Curr Biol 12:1965-1969.
4. Bridge AJ, Pebernard S, Ducraux A, Nicoulaz AL, Iggo R. 2003. Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet 34:263-264.
5. Brown WR, Hubbard SJ, Tickle C, Wilson SA. 2003. The chicken as a model for large-scale analysis of vertebrate gene function. Nat Rev Genet 4:87-98.
6. Castanotto D, Li H, Rossi JJ. 2002. Functional siRNA expression from transfected PCR products. RNA 8:1454-1460.
7. Chi JT, Chang HY, Wang NN, Chang DS, Dunphy N, Brown PO. 2003. Genomewide view of gene silencing by small interfering RNAs. Proc Natl Acad Sci U S A 100:6343-6346.
8. Eickholt BJ, Morrow R, Walsh FS, Doherty P. 1997. Structural features of collapsin required for biological activity and distribution of binding sites in the developing chick. Mol Cell Neurosci 9:358-371.
9. Eickholt BJ, Walsh FS, Doherty P. 2002. An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. J Cell Biol 157:211-217.
10. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-498.
11. Fu SY, Sharma K, Luo Y, Raper JA, Frank E, 2000. SEMA3A regulates developing sensory projections in the chicken spinal cord. J Neurobiol 45:227-236.
12. Gan L, Anton KE, Masterson BA, Vincent VA, Ye S, Gonzalez-Zulueta M. 2002. Specific interference with gene expression and gene function mediated by long dsRNA in neural cells. J Neurosci Methods 121:151-157.
13. Gou D, Jin N, Liu L. 2003. Gene silencing in mammalian cells by PCR-based short hairpin RNA. FEBS Lett 548:113-118.
14. Granata A, Quaderi NA. 2003. The Opitz syndrome gene MID1 is essential for establishing asymmetric gene expression in Hensen's node. Dev Biol 258:397-405.
15. Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD. 2003. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell 5:45-57.
16. Heimer GV, Taylor CED. 1974. Improved mountant for immunofluorescence preparations. J Clin Pathol 27:254-256.
17. Itasaki N, Bel-Vialar S, Krumlauf R. 1999. 'Shocking' developments in chick embryology: electroporation and in ovo gene expression. Nat Cell Biol 1:E203-E207.
18. Katahira T, Nakamura H. 2003. Gene silencing in chick embryos with a vector-based small interfering RNA system. Dev Growth Differ 45:361-367.
19. Kawakami Y, Rodriguez-Leon J, Koth CM, Buscher D, Itoh T, Raya A, Ng JK, Esteban CR, Takahashi S, Henrique D, Schwarz MF, Asahara H, Izpisua Belmonte JC. 2003. MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nat Cell Biol 5:513-519.
20. Kawasaki T, Bekku Y, Suto F, Kitsukawa T, Taniguchi M, Nagatsu I, Nagatsu T, Itoh K, Yagi T, Fujisawa H. 2002. Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system. Development 129:671-680.
21. Kitsukawa T, Shimizu M, Samba M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H. 1997. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron 19:995-1005.
22. Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD. 1997. Neuropilin is a semaphorin III receptor. Cell 90:753-762.
23. Kos R, Reedy MV, Johnson RL, Erickson CA. 2001. The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos. Development 128:1467-1479.
24. Lee MT, Koebbe MJ, O'Donovan MJ. 1988. The development of sensorimotor synaptic connections in the lumbosacral cord of the chick embryo. J Neurosci 8:2530-2543.
25. Luo Y, Raible D, Raper JA. 1993. Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 75:217-227.
26. Momose T, Tonegawa A, Takeuchi J, Ogawa H, Umesono K, Yasuda K. 1999. Efficient targeting of gene expression in chick embryos by microelectroporation. Dev Growth Differ 41:335-344.
27. Nasevicius A, Ekker SC. 2000. Effective targeted gene 'knockdown' in zebrafish. Nat Genet 26:216-220.
28. Ozaki S, Snider WD. 1997. Initial trajectories of sensory axons toward laminar targets in the developing mouse spinal cord. J Comp Neurol 380:215-229.
29. Pasterkamp RJ, Giger RJ, Baker RE, Hermens WT, Verhaagen J. 2000. Ectopic adenoviral vector-directed expression of Sema3A in organotypic spinal cord explants inhibits growth of primary sensory afferents. Dev Biol 220:129-141.
30. Pekarik V, Bourikas D, Miglino N, Joset P, Preiswerk S, Stoeckli ET. 2003. Screening for gene function in chicken embryo using RNAi and electroporation. Nat Biotechnol 21:93-96.
31. Petropoulos CJ, Hughes SH. 1991. Replication-competent retrovirus vectors for the transfer and expression of gene cassettes in avian cells. J Virol 65:3728-3737.
32. Puschel AW, Adams RH, Betz H. 1996. The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins. Mol Cell Neurosci 7:419-431.
33. Renzi MJ, Feiner L, Koppel AM, Raper JA. 1999. A dominant negative receptor for specific secreted semaphorins is generated by deleting an extracellular domain from neuropilin-1. J Neurosci 19:7870-7880.
34. Semizarov D, Frost L, Sarthy A, Kroeger P, Halbert DN, Fesik SW. 2003. Specificity of short interfering RNA determined through gene expression signatures. Proc Natl Acad Sci U S A 100:6347-6352.
35. Shepherd I, Luo Y, Raper JA, Chang S. 1996. The distribution of collapsin-1 mRNA in the developing chick nervous system. Dev Biol 173:185-199.
36. Shi Y. 2003. Mammalian RNAi for the masses. Trends Genet 19:9-12.
37. Siemering KR, Golbik R, Sever R, Haseloff J. 1996. Mutations that suppress the thermosensitivity of green fluorescent protein. Curr Biol 6:1653-1663.
38. Simmen KA, Waldschmidt R, Bernues J, Parry HD, Seifart KH, Mattaj IW. 1992. Proximal sequence element factor binding and species specificity in vertebrate U6 snRNA promoters. J Mol Biol 223:873-884.
39. Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BR. 2003. Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5:834-839.
40. Sugiyama S, Nakamura H. 2003. The role of Grg4 in tectal laminar formation. Development 130:451-462.
41. Sui G, Soohoo C, el Affar B, Gay F, Shi Y, Forrester WC, Shi Y. 2002. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A 99:5515-5520.
42. Vermeren M, Maro GS, Bron R, McGonnell IM, Charnay P, Topilko P, Cohen J. 2003. Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points. Neuron 37:403-415.
43. Yaneza M, Gilthorpe JD, Lumsden A, Tucker AS. 2002. No evidence for ventrally migrating neural tube cells from the mid- and hindbrain. Dev Dyn 223:163-167.
44. Yang S, Tutton S, Pierce E, Yoon K. 2001. Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells. Mol Cell Biol 21:7807-7816.