Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity

Molecular and Cellular Biology

Volumn 24, Issue 11, 2004, Pages 4636-4650

  Tognon, Cristina E ^a   Mackereth, Cameron D ^b   Somasiri, Aruna M ^b   McIntosh, Lawrence P ^b   Sorensen, Poul H B ^a  

^a CHILDREN S AND WOMEN S HEALTH CENTRE OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; EN PROTEIN; ETV6 NTRK3 PROTEIN; ETV6 PTK FUSION PROTEIN; FK 506 BINDING PROTEIN; FKBP NTRK3 PROTEIN; HYBRID PROTEIN; MONOMER; ONCOPROTEIN; PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

12P13ETV6 GENE; ANIMAL CELL; ARTICLE; CANCER; CELL LINEAGE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DIMERIZATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ETV6 GENE; ETV6 NTRK3 GENE; ETV6 SAM DOMAIN; GENE; GENE FUSION; GENE MUTATION; GENE TARGETING; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN POLYMERIZATION; SAM DOMAIN;

ANIMALS; CYCLIN D1; DIMERIZATION; DNA-BINDING PROTEINS; MICE; MUTATION; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-ETS; RECEPTOR, TRKC; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TACROLIMUS BINDING PROTEINS;

ANIMALIA;

EID: 2442650394     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.11.4636-4650.2004     Document Type: Article

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