-
1
-
-
0030221053
-
Understanding and controlling the cell cycle with natural products
-
Hung, D. T., Jamison, T. F., and Schreiber, S. L. (1996) Understanding and controlling the cell cycle with natural products. Chem. Biol. 3, 623-639.
-
(1996)
Chem. Biol.
, vol.3
, pp. 623-639
-
-
Hung, D.T.1
Jamison, T.F.2
Schreiber, S.L.3
-
2
-
-
0027756895
-
Controlling signal transduction using synthetic ligands
-
Spencer, D. M., Wandless, T. J., Schreiber, S. L., and Crabtree, G. R. (1993) Controlling signal transduction using synthetic ligands. Science 262, 1019-1024.
-
(1993)
Science
, vol.262
, pp. 1019-1024
-
-
Spencer, D.M.1
Wandless, T.J.2
Schreiber, S.L.3
Crabtree, G.R.4
-
3
-
-
0032584149
-
Synthetic activation of caspases: Artificial death switches
-
MacCorkle, R. A., Freeman, K. W., and Spencer, D. M. (1998) Synthetic activation of caspases: Artificial death switches. Proc. Natl. Acad. Sci. U.S.A. 95, 3655-3660.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 3655-3660
-
-
MacCorkle, R.A.1
Freeman, K.W.2
Spencer, D.M.3
-
4
-
-
0032790270
-
Regulation of gene expression with synthetic dimerizers
-
Pollock, R., and Rivera, V. M. (1999) Regulation of gene expression with synthetic dimerizers. Methods Enzymol. 306, 263-281.
-
(1999)
Methods Enzymol.
, vol.306
, pp. 263-281
-
-
Pollock, R.1
Rivera, V.M.2
-
5
-
-
0037007835
-
A bacterial small-molecule three-hybrid system
-
Althoff, E. A., and Cornish, V. W. (2002) A bacterial small-molecule three-hybrid system. Angew. Chem. Int. Ed. 41, 2327-2330.
-
(2002)
Angew. Chem. Int. Ed.
, vol.41
, pp. 2327-2330
-
-
Althoff, E.A.1
Cornish, V.W.2
-
6
-
-
0035941502
-
A synthetic library of cell-permeable molecules
-
Koide, K., Finkelstein, J. M., Ball. Z., and Verdine, G. L. (2001) A synthetic library of cell-permeable molecules. J. Am Chem. Soc. 123, 398-408.
-
(2001)
J. Am Chem. Soc.
, vol.123
, pp. 398-408
-
-
Koide, K.1
Finkelstein, J.M.2
Ball, Z.3
Verdine, G.L.4
-
7
-
-
0033515037
-
Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces
-
Briesewitz, R., Ray, G. T., Wandless, T. J., and Crabtree, G. R. (1999) Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces. Proc. Natl. Acad. Sci. U.S.A. 96, 1953-1958.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 1953-1958
-
-
Briesewitz, R.1
Ray, G.T.2
Wandless, T.J.3
Crabtree, G.R.4
-
8
-
-
0034614075
-
Mechanistic studies of affinity modulation
-
Rosen, M. K., Amos, C. D., and Wandless, T. J. (2000) Mechanistic studies of affinity modulation. J. Am. Chem. Soc. 122, 11979-11982.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 11979-11982
-
-
Rosen, M.K.1
Amos, C.D.2
Wandless, T.J.3
-
9
-
-
0034615062
-
Synthesis and evaluation of daunorubicin-paclitaxel dimers
-
Kar, A. K., Braun, P. D., and Wandless, T. J. (2000) Synthesis and evaluation of daunorubicin-paclitaxel dimers. Bioorg. Med. Chem. Lett. 10, 261-264.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 261-264
-
-
Kar, A.K.1
Braun, P.D.2
Wandless, T.J.3
-
10
-
-
0038546791
-
A bifunctional molecule that displays context-dependent cellular activity
-
Braun, P. D., Barglow, K. T., Lin, Y.-M., Akompong, T., Briesewitz, R., Ray, G. T., Haldar, K., and Wandless, T. J. (2003) A bifunctional molecule that displays context-dependent cellular activity. J. Am. Chem Soc. 125, 7575-7580.
-
(2003)
J. Am. Chem Soc.
, vol.125
, pp. 7575-7580
-
-
Braun, P.D.1
Barglow, K.T.2
Lin, Y.-M.3
Akompong, T.4
Briesewitz, R.5
Ray, G.T.6
Haldar, K.7
Wandless, T.J.8
-
11
-
-
0034114574
-
Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate
-
Kopytek, S. J., Standaert, R. F., Dyer, J. C. D., and Hu, J. C. (2000) Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate. Chem. Biol. 7, 313-321.
-
(2000)
Chem. Biol.
, vol.7
, pp. 313-321
-
-
Kopytek, S.J.1
Standaert, R.F.2
Dyer, J.C.D.3
Hu, J.C.4
-
12
-
-
0037433202
-
Designing protein dimerizers: The importance of ligand conformational equilibria
-
Carlson, J. C. T., Kanter, A., Thuduppathy, G. R., Cody, V., Pineda, P. E., McIvor, R. S., and Wagner, C. R. (2003) Designing protein dimerizers: the importance of ligand conformational equilibria. J. Am. Chem. Soc. 125, 1501-1507.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 1501-1507
-
-
Carlson, J.C.T.1
Kanter, A.2
Thuduppathy, G.R.3
Cody, V.4
Pineda, P.E.5
McIvor, R.S.6
Wagner, C.R.7
-
14
-
-
0002177268
-
Quantitative effects of antagonistic drugs
-
Gaddum, J. H. (1937) Quantitative effects of antagonistic drugs. J. Physiol. (Lond.) 89, 7P-9P.
-
(1937)
J. Physiol. (Lond.)
, vol.89
, pp. 7-9
-
-
Gaddum, J.H.1
-
15
-
-
0015861774
-
Relationship between inhibition constant (K1) and concentration of inhibitor which causes 50% inhibition (150) of an enzymatic reaction
-
Cheng, Y.-C., and Prusoff, W. H. (1973) Relationship between inhibition constant (K1) and concentration of inhibitor which causes 50% inhibition (150) of an enzymatic reaction. Biochem. Pharmacol. 22, 3099-3108.
-
(1973)
Biochem. Pharmacol.
, vol.22
, pp. 3099-3108
-
-
Cheng, Y.-C.1
Prusoff, W.H.2
-
16
-
-
0023918636
-
An exact correction to the Cheng-Prusoff correction
-
Munson, P. J., and Rodbard, D. (1988) An exact correction to the Cheng-Prusoff correction. J. Recept. Res. 8, 533-546.
-
(1988)
J. Recept. Res.
, vol.8
, pp. 533-546
-
-
Munson, P.J.1
Rodbard, D.2
-
18
-
-
13144276290
-
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity
-
Clackson, T., Yang, W., Rozamus, L. W., Hatada, M., Amara, J. F., Rollins, C. T., Stevenson, L. F., Magari, S. R., Wood, S. A., Courage, N. L., Lu, X., Cerasoli, F., Jr., Gilman, M., and Holt, D. A. (1998) Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc. Natl. Acad. Sci. U.S.A. 95, 10437-10442.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 10437-10442
-
-
Clackson, T.1
Yang, W.2
Rozamus, L.W.3
Hatada, M.4
Amara, J.F.5
Rollins, C.T.6
Stevenson, L.F.7
Magari, S.R.8
Wood, S.A.9
Courage, N.L.10
Lu, X.11
Cerasoli Jr., F.12
Gilman, M.13
Holt, D.A.14
-
19
-
-
0019061918
-
Ligand - A versatile computerized approach for characterization of ligand-binding systems
-
Munson, P. J., and Rodbard, D. (1980) Ligand - A versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107, 220-239.
-
(1980)
Anal. Biochem.
, vol.107
, pp. 220-239
-
-
Munson, P.J.1
Rodbard, D.2
-
20
-
-
0026415191
-
Affinogen - A program for affinity spectrum reconstruction
-
Yuryev, D. K. (1991) Affinogen - A program for affinity spectrum reconstruction. J. Immunol. Methods 139, 297-297.
-
(1991)
J. Immunol. Methods
, vol.139
, pp. 297-297
-
-
Yuryev, D.K.1
-
21
-
-
0028936571
-
An exact mathematical expression for describing competitive-binding of 2 different ligands to a protein molecule
-
Wang, Z. X. (1995) An exact mathematical expression for describing competitive-binding of 2 different ligands to a protein molecule. FEBS Lett. 360, 111-114.
-
(1995)
FEBS Lett.
, vol.360
, pp. 111-114
-
-
Wang, Z.X.1
-
22
-
-
0004149831
-
-
Cambridge University Press, Cambridge, England
-
Wolfram, S. (1999) The Mathematica Book, 4th ed., Cambridge University Press, Cambridge, England.
-
(1999)
The Mathematica Book, 4th Ed.
-
-
Wolfram, S.1
-
24
-
-
0019742129
-
Equilibrium and kinetic inhibition assays based upon fluorescence polarization
-
Dandliker, W. B., Hsu, M.-L., Levin, J., and Rao, B. R. (1981) Equilibrium and kinetic inhibition assays based upon fluorescence polarization. Methods Enzymol. 74, 3-27.
-
(1981)
Methods Enzymol.
, vol.74
, pp. 3-27
-
-
Dandliker, W.B.1
Hsu, M.-L.2
Levin, J.3
Rao, B.R.4
-
25
-
-
0030472640
-
Determination of affinities for Lck SH2 binding peptides using a sensitive fluorescence assay: Comparison between the pYEEIP and pYQPQP consensus sequences reveals context-dependent binding specificity
-
Cousins-Wasti, R. C., Ingraham, R. H., Morelock, M. M., and Grygon, C. A. (1996) Determination of affinities for Lck SH2 binding peptides using a sensitive fluorescence assay: comparison between the pYEEIP and pYQPQP consensus sequences reveals context-dependent binding specificity. Biochemistry 35, 16746-16752.
-
(1996)
Biochemistry
, vol.35
, pp. 16746-16752
-
-
Cousins-Wasti, R.C.1
Ingraham, R.H.2
Morelock, M.M.3
Grygon, C.A.4
-
26
-
-
0030993172
-
Peptide ligands of pp60(c-src) SH2 domains: A thermodynamic and structural study
-
Charifson, P. S., Shewchuk, L. M., Rocque, W., Hummel, C. W., Jordan, S. R., Mohr, C., Pacofsky, G. J., Peel, M. R., Rodriguez, M., Sternbach, D. D., and Consler, T. G. (1997) Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry 36, 6283-6293.
-
(1997)
Biochemistry
, vol.36
, pp. 6283-6293
-
-
Charifson, P.S.1
Shewchuk, L.M.2
Rocque, W.3
Hummel, C.W.4
Jordan, S.R.5
Mohr, C.6
Pacofsky, G.J.7
Peel, M.R.8
Rodriguez, M.9
Sternbach, D.D.10
Consler, T.G.11
-
27
-
-
0033527682
-
Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase
-
Bradshaw, J. M., Mitaxov, V., and Waksman, G. (1999) Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase. J. Mol. Biol. 293, 971-985.
-
(1999)
J. Mol. Biol.
, vol.293
, pp. 971-985
-
-
Bradshaw, J.M.1
Mitaxov, V.2
Waksman, G.3
-
28
-
-
0031683101
-
Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins
-
Keenan, T., Yaeger, D. R., Courage, N. L., Rollins, C. T., Pavone, M. E., Rivera, V. M., Yang, W., Guo, T., Amara, T. F., Clackson, T., Gilman, M., and Holt, D. A. (1998) Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins. Bioorg. Med. Chem. 6, 1309-1335.
-
(1998)
Bioorg. Med. Chem.
, vol.6
, pp. 1309-1335
-
-
Keenan, T.1
Yaeger, D.R.2
Courage, N.L.3
Rollins, C.T.4
Pavone, M.E.5
Rivera, V.M.6
Yang, W.7
Guo, T.8
Amara, T.F.9
Clackson, T.10
Gilman, M.11
Holt, D.A.12
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