Consideration of the pH-dependent inhibition of dihydrofolate reductase by methotrexate

Journal of Molecular Biology

Volumn 271, Issue 4, 1997, Pages 656-668

  Cannon, William R ^a   Garrison, Barbara J ^a   Benkovic, Stephen J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Dihydrofolate reductase; Inhibition; Methotrexate; pH; pK(a)

Indexed keywords

APOENZYME; ASPARTIC ACID; BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR; GLUTAMINE; HISTIDINE; METHOTREXATE; PTERIDINE;

ARTICLE; BINDING SITE; COMPLEX FORMATION; COMPUTER MODEL; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTUM CHEMISTRY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0030875357     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1173     Document Type: Article

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