Characteristics of selenazolidine prodrugs of selenocysteine: Toxicity, selenium levels, and glutathione peroxidase induction in A/J mice

Life Sciences

Volumn 75, Issue 4, 2004, Pages 447-459

  Li, Liang ^a   Xie, Yang ^a   El Sayed, Wael M ^a   Szakacs, Juliana G ^b   Roberts, Jeanette C ^a,c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Cancer chemoprevention; Prodrugs; Selenazolidines; Selenium; Selenocysteine

Indexed keywords

2 METHYLSELENAZOLIDINE CARBOXYLIC ACID; 2 OXOSELENAZOLIDINE CARBOXYLIC ACID; GLUTATHIONE PEROXIDASE; PRODRUG; SE METHYLSELENOCYSTEINE; SELENIUM; SELENIUM DERIVATIVE; SELENOCYSTEINE; SELENOMETHIONINE; SODIUM SELENITE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BODY WEIGHT; CANCER MODEL; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG ACTIVITY; DRUG SAFETY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INDUCTION; FEEDING; FEMALE; HISTOLOGY; LIVER; LUNG CARCINOGENESIS; LUNG PARENCHYMA; MEASUREMENT; MOUSE; NONHUMAN; ORGAN WEIGHT; TISSUE LEVEL; TOBACCO; TOXICITY;

ANIMALS; BODY WEIGHT; ENZYME INDUCTION; FEMALE; GLUTATHIONE PEROXIDASE; LIVER; LUNG; MICE; MICE, INBRED STRAINS; ORGAN SIZE; ORGANOSELENIUM COMPOUNDS; PRODRUGS; PROLINE; SELENIUM; SELENOCYSTEINE; TISSUE DISTRIBUTION; TOXICITY TESTS;

NICOTIANA TABACUM;

EID: 2442543196     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.12.018     Document Type: Article

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